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Recognition of an Ubiquitous Self Antigen by Prostate Cancer-Infiltrating CD8+ T Lymphocytes
Areas: Immunology, Oncology
A rising CD8+ T-cell response with reactivity to a histone H4-derived peptide was found in a screen for endogenous tumour-associated T-cell responses in a primary mouse model of prostatic adenocarcinoma.
Although histones are omnipresent in the body, the T-cell recognition of the histone peptide could be specifically linked to the prostate cancer of these mice.It seems as if the antigen repertoire that can be recognised by tumour-infiltrating T-cells is broader than previously thought. Apparently even peptides derived from ubiquitous self-antigens are amongst those that are normally not detected by the immune system.
Related antibodies on antibodies-online.com:
Prostate cancer antigen-1 (DEPC-1)
Antibodies for the research area immunology: »Show antibodies
Antibodies for the research area oncology: »Show antibodies
17.04.2008 | Anna Lena Marwedel 
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