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Systemic Leukocyte-Directed siRNA Delivery reveals Cyclin D1 as an Anti-Inflammatory Target
A recent study conducted by the Harvard Medical School reveals Cyclin D1 to be a potential anti-inflammatory target.
Cyclin D1 is an important cell cycle-regulatory molecule and an established therapeutic target for cancer. Cyclin D1 has been observed to be strongly up-regulated at sites of inflammation, so the scientists selectively silenced Cyclin D1 in leukocytes in vivo. Their approach included targeted stabilised nanoparticles (tsNPs) that were loaded with Cyclin D1-small interfering RNA (siRNA) and antibodies directed against integrin-β7 that were used to detect the specific leukocyte subsets involved in gut inflammation. Integrin-β7-tsNP-delivered Cyclin D1-siRNA successfully silenced Cyclin D1 in leukocytes and could cure experimentally induced colitis in mice by suppressing leukocyte proliferation and T helper cell 1 cytokine expression.
The application of similar methodologic approaches with siRNA may be effective in other experimental settings as well.
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17.04.2008 | Anna Lena Marwedel 
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