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Repression of the Transcription Factor Th-POK by Runx Complexes in Cytotoxic T- Cell Development
Areas: Immunology, Transcription Factors
Differentiation of class I-restricted thymocytes changed into CD4+CD8- helper-like T-cells, when Runx transcription factor complexes were absent. Usually, CD4+CD8+ double-positive thymocytes differentiate into CD4+ helper-lineage cells when expressing the transcription factor ThPOK, but without it they take the path of the cytotoxic CD8+ lineage.
Within the ThPOK locus there exists a Runx-binding sequence which acts as transcriptional silencer, essential for the development of CD8+ T-cells by blockade of ThPOK.
It seems that ThPOK expression and T-helper cell development are actively inhibited by Runx-dependent silencing, permitting cytotoxic T-cell differentiation.
Runx2
Runx3
It seems that ThPOK expression and T-helper cell development are actively inhibited by Runx-dependent silencing, permitting cytotoxic T-cell differentiation.
Related antibodies on antibodies-online.com:
Runx1Runx2
Runx3
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05.05.2008 | Anna Lena Marwedel 
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