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Spine-Type-Specific Recruitment of Newly Synthesized AMPA Receptors with Learning
Area: Neurology
Learning-associated newly synthesized GluR1 were selectively recruited to mushroom-type spines in adult hippocampal CA1 neurons 24 hours after fear conditioning, as the study conducted by the Institute for Childhood and Neglected Diseases demonstrates.
The scientists analysed the dynamics of newly synthesized AMPA-type glutamate receptors (AMPARs) in regard to learning. For this task they used transgenic mice expressing the GluR1 subunit fused to green fluorescent protein (GFP-GluR1). The fusion protein was under the control of the c-fos promoter.
The scientists analysed the dynamics of newly synthesized AMPA-type glutamate receptors (AMPARs) in regard to learning. For this task they used transgenic mice expressing the GluR1 subunit fused to green fluorescent protein (GFP-GluR1). The fusion protein was under the control of the c-fos promoter.
The results of the study are consistent with a "synaptic tagging" model, which allows activated synapses to subsequently capture newly synthesized receptors. A functional differentiation of the mushroom spines with learning was also found.
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11.06.2008 | Anna Lena Marwedel 
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