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Spine-Type-Specific Recruitment of Newly Synthesized AMPA Receptors with Learning

Learning-associated newly synthesized were selectively recruited to mushroom-type spines in adult hippocampal CA1 neurons 24 hours after fear conditioning, as the study conducted by the Institute for Childhood and Neglected Diseases demonstrates.
The scientists analysed the dynamics of newly synthesized () in regard to learning. For this task they used transgenic mice expressing the subunit fused to (-). The fusion protein was under the control of the promoter.


The results of the study are consistent with a "synaptic tagging" model, which allows activated synapses to subsequently capture newly synthesized receptors. A functional differentiation of the mushroom spines with learning was also found.

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