Defective tryptophan catabolism underlies inflammation in chronic granulomatous disease of mice
Chronic granulomatous disease (CGD) is an inherited disease, fatally impairing children's ability to survive infections. The cause is a lack of NADPH oxidase activity in the phagocytes that can not generate reactive oxygen species, most notably superoxide anion. Recurring bacterial and fungal infections are the consequences. Patients with CGD also suffer from chronic inflammatory conditions, most prominently granuloma formation in hollow viscera.