Semaphorin and neuropilin co-expression in motoneuronssets axon sensitivity to environmental semaphorin sources during motor axon pathfinding

Overexpression of Semaphorin 3A (Sema3A) causes defasciculation and excessive growth of motor axons into normally non-permissive territories, as a study conducted by scientist from the University of Lyon in France concludes. They also state that motoneuronal Sema3A is required for correct spinal nerve compaction and dorsal motor axon extension.

Class 3 semaphorins are intercellular guiding cues for migrating cells and axons, secreted by the surrounding tissues in the developing organism. They are essential for the formation of nerves and vasculature. The scientists observed Sema3A expression in motoneurons during spinal nerve development. The study uncovered how the growth cone's level of sensitivity to exogenous Sema3A exposure is influenced by Sema3A expression in motoneurons. This regulation is linked to the availability of the Sema3A receptor neuropilin 1 at the growth cone surface.

Apparently, Sema3A in motoneurons enables them to grow more or less far away from the repulsive signals given by exogenous Sema3A. This interplay between intrinsic and extrinsic Sema3A seems to be an important factor in the accurate specification of axon pathways.

Related antibodies on antibodies-online.com:

Semaphorin 3A

Neuropilin 1

Semaphorin 3C

Semaphorin 3E

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