Direct priming of antiviral CD8+ T cells in the peripheral interfollicular region of lymph nodes

Antigen presentation at the lymph node periphery has a prominent function for antiviral CD8+ T-cell activation. Previously it was believed that antiviral CD8+ T-cell activation would mainly occur at lymphocyte exit sites in deeper lymph node venules.

But scientists from the National Institute of Allergy and Infectious Diseases (USA) demonstrated by intravital microscopy how the activation takes place.

They analyzed mice infected with either vaccinia virus (a large DNA virus) or vesicular stomatitis virus (a small RNA virus). The virions drained to the lymph node and infected cells resided just beneath the subcapsular sinus. Naive CD8+ T-cells rapidly migrated to infected cells in the peripheral interfollicular region to form tight interactions with dendritic cells which completed T-cell activation.

Related antibodies on antibodies-online.com:

Vaccinia virus

Vesicular Stomatitis virus

CD8+ T-cells

Dendritic cells

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Antibodies for the research area virology: »Show antibodies