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Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independent of Pax5

In the absence of (), 'expandable' and clonal lymphoid progenitor cells seem to retain considerable myeloid potential. is assumed to play a part in the lineage restriction and fate commitment that also require transcription factor . induces and inhibits the expression of genes encoding for the transcription factors C/EBPalpha, PU.1 and .

Ectopic expression of in multipotent progenitor cells directs generation against the myeloid cell fates. Continuing expression of in -/- hematopoietic progenitor cells blocks the myeloid and T lineage potential of those cells in vivo. In -/- pro- increased expression also blocks the alternative lineage genes.
can therefore act independent of in limiting alternative lineage 'choice' and initiating commitment to the fate.

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