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Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons

Vascular-derived seem to be essential to axonal pathfinding and thus for the developing nervous system.

In mouse embryos, the family member was shown to act through the endothelin receptor EdnrA and to direct the extension of axons of some sympathetic neurons from the superior cervical ganglion to the external carotid artery. The external carotid artery is a gateway to select targets.

Newborn sympathetic neurons seem to distinguish and choose between distinct vascular trajectories to innervate their appropriate end organs.

Related antibodies on antibodies-online.com:

Endothelin

Endothelin Rezeptor Typ A (EdnrA)

Antibodies for the research area neurology:

Antibodies for the research area signalling: