Eco1-Dependent Cohesin Acetylation During Establishment of Sister Chromatid Cohesion
Eco1 modifies cohesin to stabilise sister chromatid cohesion. This has been observed by scientists from the Cancer Research UK London Research Institute. Sister chromosomes are bound to each other by chromosomal cohesin complexes ever since their synthesis in the S phase of mitosis. This is dependent on the acetyl transferase Eco1. Eco1 is associated with the replication fork but its way of function is yet unknown.