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Anomalous Type 17 Response to Viral Infection by CD8+ T Cells Lacking T-bet and Eomesodermin

that have defective and () were shown to be unable to defend the body against infection, as a study conducted by the University of Pennsylvania demonstrates.

Naïve in mammals are primed by invading pathogens and turn into cytotoxic killer cells upon contact. To fight intracellular pathogens, they can lyse the infected mammalian cells and secrete to activate intracellular microbes.

Virus-specific that lack and only differentiate into -secreting cells, similar to T helper cells that have been associated with autoimmunity and extracellular microbial defense. Mice with this kind of cells develop a -dependent, progressive and wasting syndrome upon viral infection, characterised by multi-organ infiltration of .

and are responsible for to differentiate into their designated cell fate and to turn into killer cells that are specific in intracellular instead of extracellular destruction.

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