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Modulation of Gene Expression via Disruption of NF-kappa-B Signaling by a Bacterial Small Molecule

The bacterial N-3-oxo-dodecanoyl homoserine lactone (C12) selectively impairs the regulation of functions in activated mammalian cells, according to the data of a research group from The Scripps Research Institute (USA). The nuclear is indispensable for the defence of the body against invading microbial pathogens. Activation of controls the innate immune response, thus eradicating harmful pathogens.

If is impaired by C12, -controlled genes that encode and other immune regulators are suppressed. This seems to be a strategy of C12-producing pathogens like to decrease the effect of the innate immune system on them. By this mechanism they can establish and retain long-lasting local infections in mammals, like cystic fibrosis.

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