NPR1 is regulated by the opposing action of S-nitrosoglutathione and thioredoxins, as Yasuomi Tada and colleagues from the Duke University (USA) report.

Changes in redox status during immune response could be observed in several different organisms. In plants, the conformation of NPR1 is regulated by those redox changes. NPR1 is a master regulator of salicylic acid–mediated genes that control immune defense. NPR1 is sequestered in the cytoplasm as an oligomer through intermolecular disulfide bonds.

NPR1 is S-nitrosylated by S-nitrosoglutathione at cysteine-156. This reaction enhances its oligomerisation, which is important to maintain protein homeostasis when salicylic acid is added. The NPR1 oligomer-to-monomer reaction, triggered by salicylic acid, is catalysed by thioredoxins. NPR1 reliant disease resistance was impaired by mutations in NPR1 cysteine-156 as well as thioredoxins. It seems, pathogen-triggered redox changes and gene regulation are important to plant immunity.

Related antibodies on antibodies-online.com:

NPR1

Salicylic acid (acetylated)

Thioredoxin (Trx) Family Antibody Sampler Kit

Thioredoxin

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