A research team from the University of California recently showed that adenovirus small early region 1a (e1a) protein interaction with p300 and CBP result in a threefold reduction of total cellular histone H3 lysine 18 acetylation (H3K18). CBP and p300 seem to be essential for the reaction at this position because a specific hypoacetylation occurs at H3K18 upon knockdown of their genes. The SV40 T antigen was also observed to trigger H3K18 hypoacetylation.

The binding of RB proteins and the histone acetyl transferases p300 and CBP by e1a drives cells into the S phase of the cell cycle. RB interaction removes e1a from its DNA-bound E2F transcription factors, resulting in the release of the cell cycle genes. The role of CBP and p300 may be clarified by the observation that global hypoacetylation at H3K18 occurs in prostate carcinomas with poor prognosis. Thus, the processes responsible for global H3K18 hypoacetylation could play a role oncogenic transformation.

Related antibodies on antibodies-online.com:

Adenovirus e1a

RB (retinoblastoma) proteins

p300

CREB Binding Protein (CBP)

SV40 T Antigen

Histon H3, Lysin 18 acetylated

E2F transcription factor 1

E2F transcription factor 3

Antibodies for the research area cell cycle: »Show antibodies

Antibodies for the research area oncology: »Show antibodies

Antibodies for the research area virology: »Show antibodies