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Y-box-1 protein (Yb-1) and breast cancer: Prognostic factor and target for therapy
Area: Oncology
A research group at the University of British Columbia (Vancouver) led by Sandy Dunn underlined the potential of Y-box-1 (YB-1) for the prognosis and therapy of breast cancer in two recent publications.
After analyzing more than 4049 samples the team comes to the conclusion, that a strong relationship exists between the occurrence of YB-1 and the risk of cancer relapse (See reference 1).
In addition the group shows that an inhibition of the transcription/translation factor YB-1 triggers apoptosis in aggressive tumor subtypes.
Related antibodies:
Polyclonal Y-box-1 antibodiesYB-1 (N-Term) (Human) antibodies
YB-1 (NLS) (C-Term) antibodies
Monoclonal Yb-1 antibodies for immunhistochemistry
Source: (1)Re-defining prognostic factors for breast cancer: YB-1 is a stronger predictor of relapse and disease specific survival than estrogen receptor or HER-2 across all tumor subtypes (Breast Cancer Res. 2008 Oct 16;10(5):R86), (2) Targeting YB-1 in HER-2 Overexpressing Breast Cancer Cells Induces Apoptosis via the mTOR/STAT3 Pathway and Suppresses Tumor Growth in Mice (Cancer Res. 2008 Nov 1;68(21):8661-6)
| 03.11.2008 | | | Tim Hiddemann |
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