A lab group from the University of Oxford discovered that a recombinant adenovirus–poxvirus prime-boost immunisation regime which induces strong T-cell immunogenicity is able to cause fulminant antigen-specific antibody responses. The scientists found a simple, complement-based adjuvant to support immunogenicity even more.

Antibodies directed against a malaria antigen of the blood-stage by this recombinant viral vector turned out to be highly effective against Plasmodium yoelii in mice and against Plasmodium falciparum in vitro.

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Adenovirus

T-cells

Plasmodium falciparum (Malaria)

Plasmodium falciparum

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