The intracellular pathogens Legionella pneumophila and Coxiella burnetii use a type IV secretion system to deliver a large number of different bacterial proteins with Anks (ankyrin repeat homology domains) into eukaryotic cells.

The advantage of microbial proteins that work inside a host cell is that they can imitate or disrupt eukaryotic factors. Thus, many bacteria use specialised secretion systems to get their proteins inside the eukaryotic cell.

The L. pneumophila AnkX protein was observed to prevent microtubule-dependent vesicular transport. This disturbed the fusion of L. pneumophila-containing vacuoles with late endosomes after infection of macrophages.
Ank proteins therefore must have effector functions that are important for bacterial infection of eukaryotic host cells.

Related antibodies on antibodies-online.com:

Legionella pneumophila

Ankyrin

Makrophages

Ankyrin repeat domains

Endosome-associated protein (EEA1)

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