Area: Cancer, Neurotransmitters, Signaling Nestin expression controls TGF-beta receptor signaling in astrocytoma cells Nestin is a type VI intermediate filament protein, expressed mostly in nerve cells where they are implicated in the radial growth of the axon. Nestin has recently received attention as a marker for detecting newly formed endothelial cells. A recent study in the journal Oncogene shows, that diminished integrin expression in astrocytoma cells can lead to a reduced TGFbeta receptor signaling in tumor-associated endothelial cells. The anti-nestin antibody utilized in this study is available on antibodies-online. More antibodies against nestin are available here: show »all anti-nestin antibodies. The research article can be found here: Source: » Oncogene. 2010 Jun 7. A mosaic mouse model of astrocytoma identifies alphavbeta8 integrin as a negative regulator of tumor angiogenesis. Tchaicha JH, et. al.