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Anaphase-promoting complex (APC) in the replication of human cytomegalovirus (HCMV)

Infection of quiescent cells by elicits severe cell cycle deregulation resulting in a G1/S arrest, which can be partly attributed to the inactivation of the . Various anti-CMV antibodies against ICP36, ICP8, UL83 and pp28 were used in a recent study, addressing the question what causes this effect. The results suggest that a viral early gene product is involved in APC degradation.

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