ATPases (or ATP synthases) are membrane-bound enzyme complexes that combine ATP synthesis with the transport of protons across a membrane. They thereby harness energy from a proton gradient and produce ATP. The function of ATPase can be utilized as an indicator of general health and functioning in studies, as in the case of virus infected phytoplankton in a recent publication. The study utilized an antibody against the beta subunit of ATP synthase in plants and micro-organisms.  » Read more

A recent study aimed to determine if there are added renoprotective benefits seen by combining angiotensin-converting enzyme-1 inhibitors (ACEi) with blockade of NADPH oxidase in antihypertensive therapies, and found that a combination of NADPH oxidase blockade with ACE inhibitors is a promising regimen. The study was performed using an ELISA kit against kidney injury molecule 1 (Kim-1).  » Read more

A study, recently published in the Journal of Proteome Research, revealed the tissue specific changes in expression patterns due to heat-stress in soybean seedlings. Especially the low molecular weight heat-shock protein expression was up-regulated in a tissue specific manner. Proteins important for photosynthesis and various other aspects of metabolism were down-regulated. The authors of the study used an HSP60 antibody that you may order on antibodies-online.  » Read more

Abscisic acid (ABA) is a phytohormone that plays an important role in plant growth and in the response to environmental challenges. A recent study in Plant Cell shows that certain chloroplast proteins can function as a receptor for Abscisic acid (ABA) in Arabidopsis Thaliana and that they interact with transcription factors acting as regulators of development. The study has been carried out using anti-Psbe, anti-Hcf101, and anti-Toc34 antibodies that are available on antibodies-online.  » Read more

A recent study in the Journal of Virology investigates the role of sumoylation on the replication of cytomegalovirus (CMV). CMV belongs to the herpes viruses and is widely found throughout the world. Mutations in sumoylation sites severely decrease the replication abilities of the virus. On antibodies-online you will find antibodies specific for CMV pp28, and CMV ICP36 DNA Binding Protein which have been utilized in the current study.  » Read more

A recent study investigated the feasibility of sodium lauryl sulfoacetate (SLS) as an immunoadjuvant in chickens as well as the outcome of a combination of SLS and the immunosuppressant thiamphenicol. Chickens were vaccinated with a vaccine against Newcastle disease virus and the immunoadjuvant effects of SLS were evaluated on the basis of T-cell ratio of CD4 to CD8 amongst others. For this FITC conjugated anti-CD4 and biotin conjugated anti-CD3 antibodies were utilized that can be purchased from antibodies-online. The study showed that SLS improved the humoral immune response and reversed the immunosuppressive effect of thiamphenicol in chickens.

A recent study in the Journal Vaccine has found the application of Flow Cytometry (FACS) to be useful in order to study chicken T cell biology. Following vaccination against Newcastle disease T-cell markers were compared using fluorescently labelled antibodies. These antibodies are available on antibodies-online: CD8b, CD4, CD3, CD8a, TCRgd, CD45 and CD44.  » Read more

Ganciclovir (GCV) and acyclovir (ACV) are guanine nucleoside analogues that inhibit lytic herpesvirus replication. In order to investigate the underlying mechanisms of these drugs in the treatment of Epstein-Barr virus infections, a recent study in the Journal of Virology utilized an antibody against the protein kinase BGLF4 that is available at antibodies-online.  » Read more

While the exact mechanisms are unknown, gamma/delta T cells are postulated to exert a regulatory influence during acute allergic airway disease. Allergic airway disease has been attributed to IL17 producing Th17 cells. A recently published study in Respiratory and Critical Care Medicine has found that gamma/delta T cells represent the main source of IL17 in the allergic lung. The study utilized a T-cell receptor antibody available at antibodies-online.  » Read more

The Event Dedicated to Drug Manufacturing Excellence

Innovating and streamlining manufacturing processes, while adhering to evermore and regulatory standards is one of the biggest challenges for the drug manufacturing industry today. To improve efficiency, reduce costs, accelerate time to market and maximize profits in today’s rapidly changing business environment, pharmaceutical companies need to exploit new strategies, technologies and practices.

Hosting leading industry professionals, this Pharma Manufacturing event provides a unique opportunity to hear the latest trends in drug manufacturing and network with leading industry peers.  » Read more

The SNARE protein syntaxin-1 exists in two conformations during synaptic vesicle fusion, both of which can bind to Munc18-1: the "open" conformation in the SNARE complex and a "closed" conformation outside the SNARE complex.  » Read more

A Japanese research team from the Biotechnology Research Center in Toyama performed a bioinformatic analysis of whole genome sequences in order to find orthologues of the men genes in Escherichia coli. The men genes enable microorganisms to synthesise menaquinone (vitamin K2), an essential component of the electron-transfer pathway. In E. coli it is derived from chorismate by seven enzymes.  » Read more