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|Application / Reactivity||Human|
|Enzyme Immunoassay (EIA)||2 Antibodies|
|Flow Cytometry (FACS)||232 Antibodies|
|Functional Studies (Func)||21 Antibodies|
|Immunochromatography (IC)||1 Antibodies|
|Immunocytochemistry (ICC)||16 Antibodies|
|Immunofluorescence (IF)||43 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||11 Antibodies|
|Immunohistochemistry (IHC)||49 Antibodies|
|Immunohistochemistry (Acetone-fixed) (IHC (af))||4 Antibodies|
|Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))||3 Antibodies|
|Immunohistochemistry (Formalin-fixed Sections) (IHC (f))||1 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||31 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||46 Antibodies|
|Immunohistochemistry (Zinc-fixed Sections) (IHC (zinc))||1 Antibodies|
|Immunoprecipitation (IP)||45 Antibodies|
|Immunostaining (ISt)||1 Antibodies|
|Antigen||CD40 Molecule, TNF Receptor Superfamily Member 5 (CD40) Antibodies|
|Conjugate||This CD40 antibody is conjugated to PE Alternatives|
Intracellular Flow Cytometry (ICFC)
|5 references available|
|Supplier||Log in to see|
Product Details anti-CD40 AntibodyTarget Details CD40 Application Details Handling References for anti-CD40 Antibody (ABIN2663450) Images
|Cross-Reactivity||Baboon, Chimpanzee, Cynomolgus, Rhesus Monkey, Squirrel Monkey (Saimiri spec.)|
|Purification||The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.|
Target Details CD40Product Details anti-CD40 Antibody Application Details Handling References for anti-CD40 Antibody (ABIN2663450) Images back to top
|Alternative Name||CD40 (CD40 Antibody Abstract)|
|Background||CD40 is a 48 kD type I glycoprotein also known as BP50. It is a member of the TNFR superfamily primarily expressed on B cells, macrophages, follicular dendritic cells, endothelial cells, fibroblasts, and at low levels on plasma cells. CD40 has been reported to be involved in B cell differentiation, costimulation, isotype class-switching, and protection of B cells from apoptosis. Additionally, CD40 is important for T cell-B cell interactions. The ligand of CD40 is CD154 (CD40 ligand). The 5C3 antibody has been reported to promote B cell proliferation in the presence of anti-IgM, IL-4 or PMA, partially blocking CD40 binding to CD40L, and B cells rescue from apoptosis.|
|Research Area||Stem Cells, Hematopoietic Progenitors, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells, Apoptosis/Necrosis, Inflammation, Cancer|
Application DetailsProduct Details anti-CD40 Antibody Target Details CD40 Handling References for anti-CD40 Antibody (ABIN2663450) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-CD40 Antibody Target Details CD40 Application Details References for anti-CD40 Antibody (ABIN2663450) Images back to top
|Buffer||Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Protect from prolonged exposure to light. Do not freeze.|
|Storage Comment||The antibody solution should be stored undiluted between 2°C and 8°C.|
References for anti-CD40 Antibody (ABIN2663450)Product Details anti-CD40 Antibody Target Details CD40 Application Details Handling Images back to top
Škrnjug, Guzmán, Ruecker: "Cyclic GMP-AMP displays mucosal adjuvant activity in mice." in: PLoS ONE, Vol. 9, Issue 10, pp. e110150, 2014 (PubMed).
Yoshino, Ami, Terao et al.: "Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies." in: Experimental animals / Japanese Association for Laboratory Animal Science, Vol. 49, Issue 2, pp. 97-110, 2000 (PubMed).
Pound, Challa, Holder et al.: "Minimal cross-linking and epitope requirements for CD40-dependent suppression of apoptosis contrast with those for promotion of the cell cycle and homotypic adhesions in human B cells." in: International immunology, Vol. 11, Issue 1, pp. 11-20, 1999 (PubMed).
Foy, Aruffo, Bajorath et al.: "Immune regulation by CD40 and its ligand GP39." in: Annual review of immunology, Vol. 14, pp. 591-617, 1996 (PubMed).
Banchereau, Bazan, Blanchard et al.: "The CD40 antigen and its ligand." in: Annual review of immunology, Vol. 12, pp. 881-922, 1994 (PubMed).
ImagesProduct Details anti-CD40 Antibody Target Details CD40 Application Details Handling References for anti-CD40 Antibody (ABIN2663450) back to top