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|Application / Reactivity||Human||Monkey||Mouse (Murine)||Pig (Porcine)||Rat (Rattus)|
|Western Blotting (WB)||146 Antibodies||5 Antibodies||42 Antibodies||6 Antibodies||21 Antibodies|
|Stimulation (St)||1 Antibodies|
|Neutralization (Neut)||2 Antibodies|
|Intracellular Flow Cytometry (ICFC)||8 Antibodies||11 Antibodies|
|Indirect Immunofluorescence Assay (IFA)||1 Antibodies|
|In vitro Assay (in vitro)||1 Antibodies|
|Immunostaining (ISt)||1 Antibodies|
|Immunoprecipitation (IP)||45 Antibodies||40 Antibodies||6 Antibodies|
|Immunohistochemistry (Zinc-fixed Sections) (IHC (zinc))||1 Antibodies||1 Antibodies|
|Antigen||CD40 Molecule, TNF Receptor Superfamily Member 5 (CD40) Antibodies|
|Reactivity||Human, Monkey, Mouse (Murine), Pig (Porcine), Rat (Rattus) Alternatives|
|Conjugate||This CD40 antibody is un-conjugated Alternatives|
Western Blotting (WB)
|1 reference available|
|Supplier||Log in to see|
Product Details anti-CD40 AntibodyTarget Details CD40 Application Details Handling References for anti-CD40 Antibody (ABIN222919) Images
|Blocking Peptide||Blocking peptide for this product available: ABIN412676|
|Specificity||Detects 43 kDa CD40 protein in Western blot analysis|
|Immunogen||Synthetic peptide corresponding to residues surrounding amino acids 261 of human CD40|
Target Details CD40Product Details anti-CD40 Antibody Application Details Handling References for anti-CD40 Antibody (ABIN222919) Images back to top
|Alternative Name||CD40 (CD40 Antibody Abstract)|
CD40 is a type I membrane protein found on the surface of B cells and primary carcinomas. It belongs to the TNF-R family. CD40 serves as the receptor for CD40 ligand (CD40L), a cytokine expressed on the cell surface of T cells. CD40 plays a critical role in B cell proliferation, antibody class switching, modulation of apoptosis in the germinal center throμgh interaction with T cells expressing CD40L, and activation of CD4+ T cells. In non-hemopoitic cells such as epidermal basal cells, CD40 ligation serves as the signal for inhibition of cell growth and induction of differentiation. The cytoplasmic domain of CD40 interacts with TRAF6, a TNFR associated factor homolog that mediates signaling from CD40. Ligation of CD40 with its ligand preferentially induces stress-activated protein kinases in B lymphocytes.
Synonyms: CDW40, CDw40, p50, Bp50, MGC9013, TNFRSF5
|Research Area||Stem Cells, Hematopoietic Progenitors, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells, Apoptosis/Necrosis, Inflammation, Cancer|
Application DetailsProduct Details anti-CD40 Antibody Target Details CD40 Handling References for anti-CD40 Antibody (ABIN222919) Images back to top
Western blotting (0.5-4 μg/mL).
However, the optimal conditions should be determined individually.
Country of Animal Origin: China
|Restrictions||For Research Use only|
HandlingProduct Details anti-CD40 Antibody Target Details CD40 Application Details References for anti-CD40 Antibody (ABIN222919) Images back to top
|Buffer||100 μg (0.2 mg/mL) immunoaffinity purified rabbit anti-CD40 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30 % glycerol, 0.5 % BSA, 0.01 % thimerosal.|
|Precaution of Use||This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
|Storage Comment||For long-term storage, aliquot and freeze at -70 °C.|
|Expiry Date||12 months|
References for anti-CD40 Antibody (ABIN222919)Product Details anti-CD40 Antibody Target Details CD40 Application Details Handling Images back to top
|Product cited in:||
Gao, Wagner, Fankhaenel et al.: "CD40 antisense oligonucleotide inhibition of trinitrobenzene sulphonic acid induced rat colitis." in: Gut, Vol. 54, Issue 1, pp. 70-7, 2004 (PubMed).
ImagesProduct Details anti-CD40 Antibody Target Details CD40 Application Details Handling References for anti-CD40 Antibody (ABIN222919) back to top