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anti-Rabbit CD40 antibody for Western Blotting

Recommended CD40 Antibody (supplied by: Log in to see )

Antigen
CD40 Molecule, TNF Receptor Superfamily Member 5 (CD40) Antibodies
  • 2310042E05Rik
  • AI326936
  • Bp50
  • C87049
  • C130077D06Rik
  • CDW40
  • DCTN-50
  • GMP23-48K
  • GP39
  • HIGM1
  • IGM
  • IMD3
  • p50
  • RBP50
  • T-BAM
  • Tnfrsf5
  • TNFRSF5
  • TNFSF5
  • TRAP
Reactivity
Cow (Bovine), Dog (Canine), Guinea Pig, Hamster, Human, Monkey, Mouse (Murine), Pig (Porcine), Rabbit, Rat (Rattus), Sheep (Ovine)
600
295
56
12
10
7
6
4
4
2
1
Host
Rabbit
477
207
153
24
7
2
Clonality
Polyclonal
Conjugate
This CD40 antibody is un-conjugated
92
90
51
24
20
17
14
12
12
11
9
8
8
8
8
8
8
8
8
8
7
6
6
4
4
4
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
558
197
197
106
88
76
70
49
48
20
19
11
8
8
6
4
3
3
2
2
2
2
1
1
1
1
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Catalog No. ABIN2157342
$ 264.29
Plus shipping costs $45.00

Similar anti-CD40 Antibodies

Application / Reactivity Human Monkey Mouse (Murine) Pig (Porcine) Rat (Rattus) Dog (Canine) Cow (Bovine) Guinea Pig Hamster Rabbit Sheep (Ovine)
Western Blotting (WB) 189 Antibodies 5 Antibodies 44 Antibodies 6 Antibodies 23 Antibodies 5 Antibodies 1 Antibodies 1 Antibodies 1 Antibodies 1 Antibodies 1 Antibodies
Stimulation (St) 1 Antibodies
Neutralization (Neut) 3 Antibodies
Intracellular Flow Cytometry (ICFC) 8 Antibodies 11 Antibodies
Indirect Immunofluorescence Assay (IFA) 1 Antibodies
In vitro Assay (in vitro) 6 Antibodies
Immunostaining (ISt) 1 Antibodies

General

Antigen CD40 Molecule, TNF Receptor Superfamily Member 5 (CD40) Antibodies
Reactivity Cow (Bovine), Dog (Canine), Guinea Pig, Hamster, Human, Monkey, Mouse (Murine), Pig (Porcine), Rabbit, Rat (Rattus), Sheep (Ovine)
(600), (295), (56), (12), (10), (7), (6), (4), (4), (2), (1)
Host Rabbit
(477), (207), (153), (24), (7), (2)
Clonality
Polyclonal
Conjugate This CD40 antibody is un-conjugated
(92), (90), (51), (24), (20), (17), (14), (12), (12), (11), (9), (8), (8), (8), (8), (8), (8), (8), (8), (8), (7), (6), (6), (4), (4), (4), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Western Blotting (WB)
(558), (197), (197), (106), (88), (76), (70), (49), (48), (20), (19), (11), (8), (8), (6), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1)
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Product Details anti-CD40 Antibody

Target Details CD40 Application Details Handling Images
Specificity Recognizes human, mouse, rat, bovine, dog, guinea pig, hamster, monkey, pig, rabbit and sheep CD40. Detects a band of ~45 kDa by Western blot.
Purification Peptide affinity purified.
Immunogen Synthetic peptide corresponding to 20 residues of human CD40.

Target Details CD40

Product Details anti-CD40 Antibody Application Details Handling Images back to top
Antigen
Alternative Name CD40 (CD40 Antibody Abstract)
Background Cd40 Is A 45-50 Kda Type I Membrane Protein And A Member Of The Tumor Necrosis Factor (TNF) Receptor Superfamily. Cd40 Is Also Known As Pb50 Or Cdw40. Cd40 Is Expressed Primarily By Professional Antigen-Presenting Cells And It Is Also Expressed On Non-Immune Cell Types. The Cd40 Expressed By Professional Antigen-Presenting Cells Plays A Critical Role In Co-Stimulation And Antigen-Presenting Cell Activation In T Cell-Dependent Immune Responses. Signals Generated Through Cd40 In B Cells Are Anti-Apoptotic. These Signals Are Also Required For T Cell-Dependent B Cell Activation And Proliferation, Isotype Switching, Up-Regulation Of Costimulatory Receptors, Germinal Center Formation And Memory Generation. Cd40 Signal Transduction Is Initiated By Binding Trimeric Cd40 Ligand (CD40L) Which Is Found On The Surface Of Activated T Cells. Cd40 Engages Several Signalling Pathways In B Cells And These Include Nf-Kb, The Mitogen-Activated Protein Kinases P38 And C-Jun N-Terminal Kinase. The 62 Amino Acid Cytoplasmic Domain (CD40c) Of Cd40 Contains Two Linear Tnf-Receptor Associated Factor (TRAF) Binding Domains. The Membrane Proximal Site Of Cd40c Binds Traf6 And The Membrane Distal Site Binds Traf1, 2 And 3. Cd40c Is Thought To Mediate The Cd40-Dependant Signalling Pathways By Recrui™Ent Of Traf To This Multimerized Domain. Cd40 Ligation Has Also Been Shown To Stimulate Inos Expression, And Therefore No Production, By Activating Nf-Kb In Ifn-G Treated Microglial Cells. No Derived From Microglia Has Been Implicated In The Damage Of Myelin-Producing Oligodendrocytes In Demyelinating Disorders Like Multiple Sclerosis (MS) And Neuronal Death During Alzheimers Disease And Brain Trauma. Increased Cd40-Cd40 Ligation Has Been Implicated In The Pathogenesis Of Several Autoimmune Inflammatory Diseases, Such As Ms, Arthritis And Insulin-Dependant Diabetes
Gene ID 958
Research Area Stem Cells, Hematopoietic Progenitors, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells, Apoptosis/Necrosis, Inflammation, Cancer
Pathways NF-kappaB Signaling

Application Details

Product Details anti-CD40 Antibody Target Details CD40 Handling Images back to top
Restrictions For Research Use only

Handling

Product Details anti-CD40 Antibody Target Details CD40 Application Details Images back to top
Format Liquid
Buffer In PBS containing 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Storage -20 °C
Storage Comment Long Term Storage :-20 °C