anti-Monkey CD40 Ligand antibody for Functional Studies

Recommended CD40 Ligand Antibody (supplied by: Log in to see )

Antigen
CD40 Ligand (CD40LG) Antibodies
  • CD154
  • cd40l
  • CD40L
  • HIGM1
  • IGM
  • IMD3
  • T-BAM
  • TNFSF5
  • TRAP
  • gp39
  • hCD40L
  • CD40-L
  • Cd40l
  • Ly-62
  • Ly62
  • Tnfsf5
  • CD40 ligand
  • TNF superfamily member 5
  • CD40LG
  • cd40l
  • Cd40lg
  • LOC100358388
  • CD154
Reactivity
Human, Monkey
480
242
55
20
19
10
8
8
6
5
4
3
3
3
3
2
2
1
Host
Mouse
291
175
111
51
35
26
2
1
Clonality
Monoclonal
Conjugate
This CD40 Ligand antibody is un-conjugated
75
60
44
15
15
13
13
11
9
9
9
9
9
9
9
8
8
6
6
5
5
5
4
4
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Application
Functional Studies (Func), Western Blotting (WB)
411
294
173
107
68
64
51
42
34
20
16
13
13
11
9
9
6
5
4
4
2
2
2
1
1
1
1
1
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Catalog No. ABIN1105905
$ 500.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN3199489 FACS Func ICC PE Mouse IgG1 Log in to see 24-31
1 ABIN3199487 FACS Func ICC Mouse IgG1 Log in to see 24-31
1 ABIN3199488 FACS Func ICC Mouse IgG1 Log in to see 24-31

General

Antigen CD40 Ligand (CD40LG) Antibodies
Reactivity Human, Monkey
(480), (242), (55), (20), (19), (10), (8), (8), (6), (5), (4), (3), (3), (3), (3), (2), (2), (1)
Host Mouse
(291), (175), (111), (51), (35), (26), (2), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This CD40 Ligand antibody is un-conjugated
(75), (60), (44), (15), (15), (13), (13), (11), (9), (9), (9), (9), (9), (9), (9), (8), (8), (6), (6), (5), (5), (5), (4), (4), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Application Functional Studies (Func), Western Blotting (WB)
(411), (294), (173), (107), (68), (64), (51), (42), (34), (20), (16), (13), (13), (11), (9), (9), (6), (5), (4), (4), (2), (2), (2), (1), (1), (1), (1), (1)
Pubmed 2 references available
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Product Details anti-CD40 Ligand Antibody

Target Details CD40 Ligand Application Details Handling ProductDetails: References for anti-CD40 Ligand antibody (ABIN1105905) Images
Specificity This antibody recognizes human CD40 ligand (CD40L), also referred as CD154.
Cross-Reactivity (Details) Species reactivity (tested):Human, cynomolgus monkey
Purification Protein G
Clone 24-31
Isotype IgG1

Target Details CD40 Ligand

Product Details anti-CD40 Ligand Antibody Application Details Handling ProductDetails: References for anti-CD40 Ligand antibody (ABIN1105905) Images back to top
Antigen
Alternative Name CD154 / CD40L (CD40LG Antibody Abstract)
Background CD40L is a transmembrane cell surface glycoprotein of 39 kDa expressed mainly on CD4+ T cells and platelets in an activation-dependent manner. The interaction of CD40L on activated CD4+ T cells with CD40 on antigen presenting cells is essential for the T-cell-dependent humoral immune respons. It has a role in T cell-dependent B-cell proliferation, differentiation and memory cell formation. Blocking of the CD40-CD40L interaction results in immunoglobulin isotype switch. Defects in CD40L are the cause of X-linked immunodeficiency with hyper-IgM type Ig which is characterized by elavated concentrations of serum IgMs and decreased amounts of all other types. In vivo, interruption of the CD40 signalling system limits experimental autoimmune diseases such as collagen-induced arthritis, lupus nephritis, rheumatoid arthritis, systemic lupus erythematosus (SLE) and acute or chronic graft-versus-host disease. CD40/CD40L is involved in angiogenic processes. In this process activated platelets are the source of CD40L for CD40 expressed by endothelial cells.Synonyms: CD40 ligand, CD40-L, CD40LG, GP39, T-cell antigen Gp39, TNF-related activation protein, TNFSF5, TRAP, Tumor necrosis factor ligand superfamily member 5
Gene ID 21947
NCBI Accession NP_035746
UniProt P27548
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways NF-kappaB Signaling, Production of Molecular Mediator of Immune Response

Application Details

Product Details anti-CD40 Ligand Antibody Target Details CD40 Ligand Handling ProductDetails: References for anti-CD40 Ligand antibody (ABIN1105905) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-CD40 Ligand Antibody Target Details CD40 Ligand Application Details ProductDetails: References for anti-CD40 Ligand antibody (ABIN1105905) Images back to top
Concentration 0.1 mg/mL
Buffer PBS, 0.1 % bovine serum albumin
Storage 4 °C
Storage Comment Store at 2 - 8 °C.

ProductDetails: References for anti-CD40 Ligand antibody (ABIN1105905)

Product Details anti-CD40 Ligand Antibody Target Details CD40 Ligand Application Details Handling Images back to top
Background publications

Nakamura, Tanaka, Satoh, Kawai, Hirakata, Kaburaki, Kawakami, Ikeda, Kuwana: "Autoantibody to CD40 ligand in systemic lupus erythematosus: association with thrombocytopenia but not thromboembolism." in: Rheumatology (Oxford, England), Vol. 45, Issue 2, pp. 150-6, 2006

Kissel, Berber, Nockher, Santoso, Bein, Hackstein: "Human platelets target dendritic cell differentiation and production of proinflammatory cytokines." in: Transfusion, Vol. 46, Issue 5, pp. 818-27, 2006