anti-Rat (Rattus) EGFR antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended EGFR Antibody (supplied by: Log in to see )

Antigen
Epidermal Growth Factor Receptor (EGFR) Antibodies
  • C-erb
  • CG10079
  • D-EGFR
  • D-Egf
  • DEGFR
  • DER
  • DER flb
  • DER/EGFR
  • DER/faint little ball
  • DER/top
  • DER/torpedo
  • DER1
  • DEgfr
  • Degfr
  • Der
  • DmHD-33
  • Dmel\\CG10079
  • EFG-R
  • EGF-R
  • EGFR
  • EGFr
  • EGfr
  • EK2-6
  • Egf
  • Egf-r
  • EgfR
  • El
  • Elp
  • Elp-1
  • Elp-B1
  • Elp-B1RB1
  • HD-33
  • TOP
  • Torpedo/DER
  • Torpedo/Egfr
  • c-erbB
  • d-egf-r
  • dEGFR
  • dEGFR1
  • dEgfr
  • der
  • egfr
  • flb
  • l(2)05351
  • l(2)09261
  • l(2)57DEFa
  • l(2)57EFa
  • l(2)57Ea
  • mor1
  • top
  • top/DER
  • top/flb
  • torpedo/Egfr
  • torpedo/egfr
  • EGFR12
  • EGFR15
  • egfr1
  • Erbb2
  • ERBB
  • ERBB1
  • HER1
  • PIG61
  • mENA
  • ErbB-1
  • Errp
  • 9030024J15Rik
  • AI552599
  • Erbb
  • Errb1
  • Wa5
  • wa-2
  • wa2
  • epidermal growth factor receptor
  • Epidermal growth factor receptor
  • epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
  • EGFR
  • Egfr
  • egfra
  • egfr1
  • LOC5564544
Epitope
AA 975-1015
147
135
64
63
59
57
56
54
53
52
48
48
43
42
39
36
33
30
30
29
27
26
25
25
22
19
18
18
18
18
17
16
16
16
16
15
15
15
15
14
14
14
13
11
9
9
8
8
8
7
6
6
6
6
5
5
5
4
4
4
4
4
4
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
2440
849
683
29
24
18
17
15
15
6
3
2
2
2
1
1
1
Host
Rabbit
1479
859
81
44
9
3
2
1
1
Clonality
Polyclonal
Conjugate
This EGFR antibody is un-conjugated
104
82
73
65
56
54
54
32
32
28
28
28
28
28
28
28
26
25
24
24
21
21
21
21
21
21
20
18
2
2
2
2
2
2
2
2
2
2
2
2
2
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
1469
678
615
555
502
271
259
229
124
84
66
56
40
24
19
14
12
11
7
5
4
4
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Options
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Catalog No. ABIN725720
$ 306.90
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN725723 IF (p) Cy3 Rabbit IgG AA 975-1015 Log in to see Polyclonal
1 ABIN725726 IF (p) Cy7 Rabbit IgG AA 975-1015 Log in to see Polyclonal
1 ABIN725724 IF (p) Cy5 Rabbit IgG AA 975-1015 Log in to see Polyclonal
1 ABIN725727 IF (p) FITC Rabbit IgG AA 975-1015 Log in to see Polyclonal
1 ABIN725725 IF (p) Cy5.5 Rabbit IgG AA 975-1015 Log in to see Polyclonal
1 ABIN895012 IF (p) Alexa Fluor 555 Rabbit IgG AA 975-1015 Log in to see Polyclonal
1 ABIN895013 IF (p) Alexa Fluor 647 Rabbit IgG AA 975-1015 Log in to see Polyclonal
1 ABIN895017 IF (p) Alexa Fluor 350 Rabbit IgG AA 975-1015 Log in to see Polyclonal
1 ABIN895015 IF (p) Alexa Fluor 488 Rabbit IgG AA 975-1015 Log in to see Polyclonal
1 ABIN2812702 IF (p) Alexa Fluor 594 Rabbit IgG AA 975-1015 Log in to see Polyclonal
1 ABIN874001 IF (p) Alexa Fluor 350 Rabbit IgG pSer1070 Log in to see Polyclonal
1 ABIN874002 IF (p) Alexa Fluor 488 Rabbit IgG pSer1070 Log in to see Polyclonal
1 ABIN874004 IF (p) Alexa Fluor 555 Rabbit IgG pSer1070 Log in to see Polyclonal
1 ABIN874087 IF (p) Alexa Fluor 647 Rabbit IgG pSer1166 Log in to see Polyclonal
1 ABIN874088 IF (p) Alexa Fluor 555 Rabbit IgG pSer1166 Log in to see Polyclonal
1 ABIN874003 IF (p) Alexa Fluor 647 Rabbit IgG pSer1070 Log in to see Polyclonal
1 ABIN874085 IF (p) Alexa Fluor 350 Rabbit IgG pSer1166 Log in to see Polyclonal
1 ABIN874086 IF (p) Alexa Fluor 488 Rabbit IgG pSer1166 Log in to see Polyclonal
1 ABIN876987 IF (p) Alexa Fluor 647 Rabbit IgG pSer768 Log in to see Polyclonal
1 ABIN876988 IF (p) Alexa Fluor 488 Rabbit IgG pSer768 Log in to see Polyclonal

General

Antigen Epidermal Growth Factor Receptor (EGFR) Antibodies
Epitope AA 975-1015
(147), (135), (64), (63), (59), (57), (56), (54), (53), (52), (48), (48), (43), (42), (39), (36), (33), (30), (30), (29), (27), (26), (25), (25), (22), (19), (18), (18), (18), (18), (17), (16), (16), (16), (16), (15), (15), (15), (15), (14), (14), (14), (13), (11), (9), (9), (8), (8), (8), (7), (6), (6), (6), (6), (5), (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(2440), (849), (683), (29), (24), (18), (17), (15), (15), (6), (3), (2), (2), (2), (1), (1), (1)
Host Rabbit
(1479), (859), (81), (44), (9), (3), (2), (1), (1)
Clonality
Polyclonal
Conjugate This EGFR antibody is un-conjugated
(104), (82), (73), (65), (56), (54), (54), (32), (32), (28), (28), (28), (28), (28), (28), (28), (26), (25), (24), (24), (21), (21), (21), (21), (21), (21), (20), (18), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(1469), (678), (615), (555), (502), (271), (259), (229), (124), (84), (66), (56), (40), (24), (19), (14), (12), (11), (7), (5), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
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Product Details anti-EGFR Antibody

Target Details EGFR Application Details Handling Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human EGFR
Isotype IgG

Target Details EGFR

Product Details anti-EGFR Antibody Application Details Handling Images back to top
Antigen
Alternative Name EGFR (EGFR Antibody Abstract)
Background

Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Isoform 2 may act as an antagonist of EGF action.

Subcellular location: Cytoplasm

Synonyms: ERBB, HER1, mENA, ERBB1, PIG61, NISBD2, Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, EGFR

Gene ID 1956
UniProt P00533
Research Area Cancer, Tyrosine Kinases, Growth Factors, Hormones, Receptors
Pathways NF-kappaB Signaling, RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Hepatitis C, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation

Application Details

Product Details anti-EGFR Antibody Target Details EGFR Handling Images back to top
Application Notes IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only

Handling

Product Details anti-EGFR Antibody Target Details EGFR Application Details Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

Images

Product Details anti-EGFR Antibody Target Details EGFR Application Details Handling back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-Epidermal Growth Factor Receptor (EGFR) (AA 975-1015) antibody (ABIN725720) Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-EGFR Poly...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Epidermal Growth Factor Receptor (EGFR) (AA 975-1015) antibody (ABIN725720) Paraformaldehyde-fixed, paraffin embedded human brain glioma, Antigen retrieval by bo...