anti-Rat (Rattus) Growth Hormone Receptor antibody for ELISA

Recommended Growth Hormone Receptor Antibody (supplied by: Log in to see )

Antigen
Growth Hormone Receptor (GHR) Antibodies
  • GHR
  • ghr
  • BVRB
  • FLR
  • SDR43U1
  • GHBP
  • GHR/BP
  • AA986417
  • growth hormone receptor
  • biliverdin reductase B (flavin reductase (NADPH))
  • ghr
  • GHR
  • LOC100304685
  • BLVRB
  • Ghr
Epitope
AA 1-265
15
8
5
4
4
4
3
2
2
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Rat (Rattus)
66
37
34
17
2
2
1
1
1
1
Host
Rabbit
67
16
2
Clonality
Polyclonal
Conjugate
This Growth Hormone Receptor antibody is un-conjugated
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA
52
28
13
13
13
11
5
3
3
2
2
2
1
1
1
Supplier
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Catalog No. ABIN2001605
$ 218.90
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN3181426 ELISA WB Rabbit IgG Internal Region Log in to see Polyclonal
1 ABIN1585686 IHC ELISA WB Rabbit Middle Region Log in to see Polyclonal
1 ABIN2604734 ELISA WB Rabbit IgG AA 353-588 Log in to see Polyclonal
1 ABIN2692234 ELISA Rabbit IgG AA 1-265 Log in to see Polyclonal
1 ABIN2425987 IHC ELISA Rabbit IgG Log in to see Polyclonal
1 ABIN2931770 ELISA IF/ICC IHC WB Rabbit Log in to see Polyclonal

General

Antigen Growth Hormone Receptor (GHR) Antibodies
Epitope AA 1-265
(15), (8), (5), (4), (4), (4), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Rat (Rattus)
(66), (37), (34), (17), (2), (2), (1), (1), (1), (1)
Host Rabbit
(67), (16), (2)
Clonality
Polyclonal
Conjugate This Growth Hormone Receptor antibody is un-conjugated
(3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application ELISA
(52), (28), (13), (13), (13), (11), (5), (3), (3), (2), (2), (2), (1), (1), (1)
Pubmed 6 references available
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Product Details anti-Growth Hormone Receptor Antibody

Target Details Growth Hormone Receptor Application Details Handling ProductDetails: References for anti-Growth Hormone Receptor antibody (ABIN2001605) Images
Specificity Rat Growth Hormone Receptor / GHR / GHBP
Characteristics Produced in rabbits immunized with purified, recombinant Rat Growth Hormone Receptor / GHR / GHBP (rR Growth Hormone Receptor / GHR / GHBP, ABIN2009068 P16310-1, Met 1-Arg 265,. Growth Hormone Receptor / GHR / GHBP specific IgG was purified by Rat Growth Hormone Receptor / GHR / GHBP affinity chromatography.
Purification purified by affinity chromatography
Sterility 0.2 μm filtered
Immunogen Recombinant Rat Growth Hormone Receptor / GHR / GHBP Protein (ABIN2009068)
Isotype IgG

Target Details Growth Hormone Receptor

Product Details anti-Growth Hormone Receptor Antibody Application Details Handling ProductDetails: References for anti-Growth Hormone Receptor antibody (ABIN2001605) Images back to top
Antigen
Alternative Name GHR (GHR Antibody Abstract)
Background Growth hormone receptor, also known as GH receptor, Somatotropin receptor and GHR, is a single-pass type I, membrane protein which belongs to the,type I, cytokine receptor family and type 1 subfamily. GHR contains one,fibronectin type-III domain. Growth hormone receptor / GHR is expressed in various tissues with high expression in liver and skeletal muscle. Isoform,4,of GHR is predominantly expressed in kidney, bladder, adrenal gland and brain stem. Isoform,1 expression of GHR in placenta is predominant in chorion and decidua. Isoform,4,is highly expressed in placental villi. Isoform,2,of GHR is expressed in lung, stomach and muscle. Growth hormone receptor / GHR is a receptor for pituitary gland growth hormone. It is involved in regulating postnatal body growth. On ligand binding, it couples to the JAK2 / STAT5 pathway. Isoform,2,of GHR up- regulates the production of GHBP and acts as a negative inhibitor of GH signaling. Defects in GHR are a cause of Laron syndrome (LARS) which is a severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone. Defects in GHR may also be a cause of idiopathic short stature autosomal (ISSA) which is defined by a subnormal rate of growth.
UniProt P16310-1
Pathways NF-kappaB Signaling, JAK-STAT Signaling, Response to Growth Hormone Stimulus

Application Details

Product Details anti-Growth Hormone Receptor Antibody Target Details Growth Hormone Receptor Handling ProductDetails: References for anti-Growth Hormone Receptor antibody (ABIN2001605) Images back to top
Application Notes ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Rat GHR. The detection limit for Rat GHR is approximately 0.00245 ng/well.
Restrictions For Research Use only

Handling

Product Details anti-Growth Hormone Receptor Antibody Target Details Growth Hormone Receptor Application Details ProductDetails: References for anti-Growth Hormone Receptor antibody (ABIN2001605) Images back to top
Format Liquid
Buffer 0.2 μm filtered solution in PBS with 5 % trehalose
Preservative Without preservative
Handling Advice Avoid repeated freeze-thaw cycles.
Storage 4 °C,-20 °C,-80 °C
Storage Comment This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Expiry Date 12 months

ProductDetails: References for anti-Growth Hormone Receptor antibody (ABIN2001605)

Product Details anti-Growth Hormone Receptor Antibody Target Details Growth Hormone Receptor Application Details Handling Images back to top
Background publications

Faustino, Miranda, do Céu Silva, Alves, Picanço, Ferreira, Seixas, Pina, Romão: "Hb Yaoundé [beta134(H12)Val-->Ala] in association with Hb C [beta6(A3)Glu-->Lys] in a Caucasian Portuguese family." in: Hemoglobin, Vol. 28, Issue 3, pp. 229-35, 2004

Jorge, Souza, Arnhold, Mendonca et al.: "The first homozygous mutation (S226I) in the highly-conserved WSXWS-like motif of the GH receptor causing Laron syndrome: supression of GH secretion by GnRH analogue therapy not restored by ..." in: Clinical endocrinology, Vol. 60, Issue 1, pp. 36-40, 2003

Enberg, Luthman, Segnestam, Ritzén, Sundström, Norstedt: "Characterisation of novel missense mutations in the GH receptor gene causing severe growth retardation." in: European journal of endocrinology / European Federation of Endocrine Societies, Vol. 143, Issue 1, pp. 71-6, 2000

Pantel, Machinis, Sobrier, Duquesnoy, Goossens, Amselem: "Species-specific alternative splice mimicry at the growth hormone receptor locus revealed by the lineage of retroelements during primate evolution." in: The Journal of biological chemistry, Vol. 275, Issue 25, pp. 18664-9, 2000

Sobrier, Dastot, Duquesnoy, Kandemir, Yordam, Goossens, Amselem: "Nine novel growth hormone receptor gene mutations in patients with Laron syndrome." in: The Journal of clinical endocrinology and metabolism, Vol. 82, Issue 2, pp. 435-7, 1997

Leung, Spencer, Cachianes, Hammonds, Collins, Henzel, Barnard, Waters, Wood: "Growth hormone receptor and serum binding protein: purification, cloning and expression." in: Nature, Vol. 330, Issue 6148, pp. 537-43, 1988