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anti-Human IKBKB Antibodies:
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Human Monoclonal IKBKB Primary Antibody for CyTOF, FACS - ABIN252473
Verma, Stevenson, Schwarz, Van Antwerp, Miyamoto: Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation. in Genes & development 1995
Show all 57 Pubmed References
Human Monoclonal IKBKB Primary Antibody for FACS - ABIN4324267
Manna, Mukhopadhyay, Aggarwal: Leflunomide suppresses TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal protein kinase, and apoptosis. in Journal of immunology (Baltimore, Md. : 1950) 2000
Show all 37 Pubmed References
Human Monoclonal IKBKB Primary Antibody for IP, WB - ABIN967355
DiDonato, Hayakawa, Rothwarf, Zandi, Karin: A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB. in Nature 1997
Show all 12 Pubmed References
Human Monoclonal IKBKB Primary Antibody for FACS, GS - ABIN252477
Vacca, Felli, Palermo, Di Mario, Calce, Di Giovine, Frati, Gulino, Screpanti: Notch3 and pre-TCR interaction unveils distinct NF-kappaB pathways in T-cell development and leukemia. in The EMBO journal 2006
Show all 9 Pubmed References
Human Polyclonal IKBKB Primary Antibody for IF, IHC (p) - ABIN1882097
Tang, Inohara, Wang, Nuñez, Guan: Roles for homotypic interactions and transautophosphorylation in IkappaB kinase beta IKKbeta) activation [corrected]. in The Journal of biological chemistry 2003
Show all 8 Pubmed References
Human Monoclonal IKBKB Primary Antibody for WB - ABIN1882049
Edwards: Anticipation of disaster. in Journal of the Royal Society of Medicine 1991
Show all 7 Pubmed References
Human Monoclonal IKBKB Primary Antibody for WB - ABIN387826
Niida, Tanaka, Kamitani: Downregulation of active IKK beta by Ro52-mediated autophagy. in Molecular immunology 2010
Show all 11 Pubmed References
Human Polyclonal IKBKB Primary Antibody for IHC - ABIN966373
Mercurio, Zhu, Murray, Shevchenko, Bennett, Li, Young, Barbosa, Mann, Manning, Rao: IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation. in Science (New York, N.Y.) 1997
Show all 11 Pubmed References
Human Polyclonal IKBKB Primary Antibody for IHC - ABIN966372
Hu, Wang: IkappaB kinase-alpha and -beta genes are coexpressed in adult and embryonic tissues but localized to different human chromosomes. in Gene 1999
Show all 11 Pubmed References
Human Polyclonal IKBKB Primary Antibody for IHC - ABIN966371
Shindo, Nakano, Sakon, Yagita, Mihara, Okumura: Assignment of IkappaB kinase beta (IKBKB) to human chromosome band 8p12-->p11 by in situ hybridization. in Cytogenetics and cell genetics 1998
Show all 11 Pubmed References
crystal structure of IKKbeta in complex with an inhibitor, at a resolution of 3.6 A
These results suggested that APN (show ANPEP Antibodies) ameliorated endothelial inflammation and IR through ROS (show ROS1 Antibodies)/IKKbeta pathway.
p300 (show EP300 Antibodies)-dependent histone H3 (show HIST3H3 Antibodies) acetylation and C/EBPbeta (show CEBPB Antibodies)-regulated IKKbeta expression contribute to thrombin (show F2 Antibodies)-induced IL-8/CXCL8 (show IL8 Antibodies) expression in human lung epithelial cells.
EGFR (show EGFR Antibodies)/PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies)/IKK-beta/NF-kappaB (show NFKB1 Antibodies) signaling promotes head and neck cancer progression.
our results illustrate a new direction in nitrosourea treatment, and reveal that the combination of ROS (show ROS1 Antibodies)-inducing IKKbeta inhibitors with nitrosoureas can be potentially exploited for melanoma therapy
Smad7 (show SMAD7 Antibodies) expression in necrotizing enterocolitis macrophages interrupts TGF-beta (show TGFB1 Antibodies) signaling and promotes NF-kappaB (show NFKB1 Antibodies)-mediated inflammatory signaling in these cells through increased expression of IKK-beta
High IKBKB expression is associated with prostate cancer.
Akt2 (show AKT2 Antibodies), Erk2 (show MAPK1 Antibodies), and IKK1 (show CHUK Antibodies)/2 phosphorylate Bcl3 (show BCL3 Antibodies), converting Bcl3 (show BCL3 Antibodies) into a transcriptional coregulator by facilitating its recruitment to DNA.
Rare variants in IKBKB are associated with decreased waist-to-hip ratio in European-Americans.
pVHL (show VHL Antibodies) mediates K63-linked ubiquitination of IKKbeta, which plays a role in the regulation of IKK (show CHUK Antibodies)/NF-kappaB (show NFKB1 Antibodies) signalling.
N-acetyl-seryl-aspartyl-lysyl-proline inhibition of TNF-alpha (show TNF Antibodies) activation of canonical, i.e., IKK-beta-dependent, NF-kappaB (show NFKB1 Antibodies) pathway and subsequent decrease in ICAM-1 (show ICAM1 Antibodies) expression is achieved via inhibition of IKK-beta.
Staphylococcus aureus infection inhibits nuclear factor kappa B activation mediated by prolactin (show PRL Antibodies) in bovine mammary epithelial cells.
Elevated levels of common free fatty acids found in human serum activate IKKbeta in bovine endothelial cells leading to reduced nitric oxide, and may serve to link pathways involved in inflammation and endothelial dysfunction.
High glucose treatment also activated IKKbeta, and pretreatment with aspirin, a pharmacological inhibitor of IKKbeta, prevented both glucose-induced IKKbeta activation and the effect of high glucose to impair insulin (show INS Antibodies)-mediated NO production.
High glucose-induced IKK (show CHUK Antibodies)-Hsp-90 (show HSP90 Antibodies) interaction contributes to endothelial dysfunction.
Expression of both wild-type and catalytically-inactive Y7F mutant GSTP (show GSTP1 Antibodies) significantly attenuated LPS (show TLR4 Antibodies)- or IKKbeta-induced production of GM-CSF (show CSF2 Antibodies). These studies indicate a complex role for GSTP (show GSTP1 Antibodies) in modulating NF-kappaB (show NFKB1 Antibodies), which may involve S-glutathionylation of IKK (show CHUK Antibodies) proteins, and interaction with NF-kappaB (show NFKB1 Antibodies) family members.
Myeloid ikkbeta gene deletion significantly reduced the percentage of CD4 (show CD4 Antibodies)(+)/IFN-gamma (show IFNG Antibodies)(+) (Th1 (show HAND1 Antibodies)) and CD4 (show CD4 Antibodies)(+)/IL-17 (show IL17A Antibodies)(+) (Th17) cells
Pharmacological and genetic inhibition of IKKbeta decreased voluntary ethanol consumption, providing initial support for IKKbeta as a potential therapeutic target for alcohol abuse.
Myeloid IKKbeta deficiency prevents Western diet-induced obesity and visceral adiposity in females but not in males, and attenuates hyperglycemia, global insulin (show INS Antibodies) resistance, and non-alcoholic steatohepatitis in both genders. In contrast, all metabolic sequela including non-alcoholic steatohepatitis are aggravated by hepatocyte IKKbeta deficiency (IkbkbDeltahep) in male but not female mice.
lymphocyte-specific deletion of IKK2 or NEMO (show IKBKG Antibodies) aggravated kidney injury after ischemia-reperfusion injury, and, in both conditions, the percentage of Th17 cells was increased.
data clearly demonstrate that KLHL21 (show KLHL21 Antibodies) negatively regulates TNFalpha (show TNF Antibodies)-activated NF-kappaB (show NFKB1 Antibodies) signaling via targeting IKKbeta, providing new insight into the mechanisms underlying NF-kappaB (show NFKB1 Antibodies) regulation in cells.
Study used three experimental approaches to enhance the IKKbeta activity in the liver of obese mice and observed increased XBP1s activity, reduced endoplasmic reticulum stress, and a significant improvement in insulin (show INS Antibodies) sensitivity and consequently in glucose homeostasis.
Mutation of cysteine 46 in IKK-beta increases inflammatory responses.
TAK1 (show NR2C2 Antibodies) and IKK2 are novel mediators of SCF (show KITLG Antibodies)-induced signaling and potential targets for c-Kit (show KIT Antibodies)-driven diseases.
MyD88s is positively regulated by IKKbeta and CREB (show CREB1 Antibodies) and negatively regulated by ERK1/2 (show MAPK1/3 Antibodies) signaling pathways.
The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene.
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
, inhibitor of nuclear factor kappa-B kinase subunit beta
, inhibitor of nuclear factor kappa-B kinase subunit beta-like
, IKK-like protein
, LPS-responsive kinase
, cactus kinase
, deficient 5
, immune response
, lipopolysaccharide activated kinase
, mmune response deficient 5
, I-kappa-B kinase 2
, I-kappa-B-kinase beta
, nuclear factor NF-kappa-B inhibitor kinase beta
, inhibitor of kappaB kinase beta
, inhibitor of nuclear factor kappa B kinase beta subunit
, inhibitor of kappa light chain gene enhancer in B cells, kinase beta