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anti-Human IKBKB antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended IKBKB Antibody (supplied by: Log in to see )

Antigen
Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB) Antibodies
  • ikk-beta
  • ikk2
  • ikkb
  • ikkbeta
  • IKBKB
  • IKKB
  • CG4201
  • DIK
  • DLAK
  • DmIKK
  • DmIKKBeta
  • DmIKKb
  • DmIKKbeta
  • DmIkkbeta
  • Dmel\\CG4201
  • Dmikkb
  • Dmikkbeta
  • IK
  • IKK
  • IKK-beta
  • IKKb
  • IKKbeta
  • IRD-5
  • IRD5
  • Ik
  • Ikkb
  • Ikkbeta
  • Ird-5
  • Ird5
  • LRK
  • Lak
  • anon-89Bd
  • dIKK
  • dIKK-beta
  • dIKKbeta
  • dLak
  • dmIKKbeta
  • ikk
  • ird
  • ird5/DmIkk[beta]
  • IKK2
  • NFKBIKB
  • AIM-1
  • AI132552
  • IKK-2
  • IKK[b]
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
  • immune response deficient 5
  • inhibitor of kappaB kinase beta
  • ikbkb
  • IKBKB
  • ird5
  • Ikbkb
Epitope
AA 180-230, pTyr199
50
33
27
22
21
21
20
20
20
20
20
20
20
19
19
19
19
16
16
16
14
8
8
8
7
6
6
5
5
4
4
4
4
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
655
227
158
22
13
7
7
6
5
4
1
1
Host
Rabbit
554
115
9
2
Clonality
Polyclonal
Conjugate
This IKBKB antibody is un-conjugated
38
37
37
33
31
31
9
7
5
5
5
5
5
5
5
5
5
2
2
2
2
2
2
2
2
2
2
2
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
311
277
264
100
74
73
67
41
37
34
6
6
6
5
3
3
2
2
1
Options
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Catalog No. ABIN743243
$ 317.90
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN2814716 IF (p) Alexa Fluor 594 Rabbit IgG AA 180-230, pTyr199 Log in to see Polyclonal
1 ABIN743250 IF (p) FITC Rabbit IgG AA 180-230, pTyr199 Log in to see Polyclonal
1 ABIN743248 IF (p) Cy5.5 Rabbit IgG AA 180-230, pTyr199 Log in to see Polyclonal
1 ABIN879203 IF (p) Alexa Fluor 350 Rabbit IgG AA 180-230, pTyr199 Log in to see Polyclonal
1 ABIN879204 IF (p) Alexa Fluor 488 Rabbit IgG AA 180-230, pTyr199 Log in to see Polyclonal
1 ABIN879206 IF (p) Alexa Fluor 647 Rabbit IgG AA 180-230, pTyr199 Log in to see Polyclonal
1 ABIN879205 IF (p) Alexa Fluor 555 Rabbit IgG AA 180-230, pTyr199 Log in to see Polyclonal
1 ABIN743246 IF (p) Cy3 Rabbit IgG AA 180-230, pTyr199 Log in to see Polyclonal
1 ABIN743247 IF (p) Cy5 Rabbit IgG AA 180-230, pTyr199 Log in to see Polyclonal
1 ABIN743249 IF (p) Cy7 Rabbit IgG AA 180-230, pTyr199 Log in to see Polyclonal
1 ABIN802135 IF (p) FITC Rabbit IgG pSer476 Log in to see Polyclonal
1 ABIN879170 IF (p) Alexa Fluor 555 Rabbit IgG pTyr188 Log in to see Polyclonal
1 ABIN879173 IF (p) Alexa Fluor 647 Rabbit IgG pTyr188 Log in to see Polyclonal
1 ABIN802131 IF (p) Cy3 Rabbit IgG pSer476 Log in to see Polyclonal
1 ABIN802133 IF (p) Cy5.5 Rabbit IgG pSer476 Log in to see Polyclonal
1 ABIN802134 IF (p) Cy7 Rabbit IgG pSer476 Log in to see Polyclonal
1 ABIN2814717 IF (p) Alexa Fluor 594 Rabbit IgG pTyr188 Log in to see Polyclonal
1 ABIN2814721 IF (p) Alexa Fluor 594 Rabbit IgG pSer476 Log in to see Polyclonal
1 ABIN2814718 IF (p) Alexa Fluor 594 Rabbit IgG pSer471 Log in to see Polyclonal
1 ABIN2814719 IF (p) Alexa Fluor 594 Rabbit IgG pSer740 Log in to see Polyclonal

Similar anti-IKBKB Antibodies

Application / Reactivity Rat (Rattus) Mouse (Murine)
ELISA 30 Antibodies 43 Antibodies
Enzyme Immunoassay (EIA) 1 Antibodies 1 Antibodies
Immunochromatography (IC) 1 Antibodies 1 Antibodies
Immunocytochemistry (ICC) 2 Antibodies
Immunofluorescence (IF) 20 Antibodies
Immunofluorescence (fixed cells) (IF/ICC) 3 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 53 Antibodies
Immunohistochemistry (IHC) 42 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 33 Antibodies
Immunoprecipitation (IP) 10 Antibodies
Western Blotting (WB) 83 Antibodies
Cytometry by Time of Flight (CyTOF) 2 Antibodies
Dot Blot (DB) 21 Antibodies
Flow Cytometry (FACS) 36 Antibodies
Gel Shift (GS) 3 Antibodies

General

Antigen Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB) Antibodies
Epitope AA 180-230, pTyr199
(50), (33), (27), (22), (21), (21), (20), (20), (20), (20), (20), (20), (20), (19), (19), (19), (19), (16), (16), (16), (14), (8), (8), (8), (7), (6), (6), (5), (5), (4), (4), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(655), (227), (158), (22), (13), (7), (7), (6), (5), (4), (1), (1)
Host Rabbit
(554), (115), (9), (2)
Clonality
Polyclonal
Conjugate This IKBKB antibody is un-conjugated
(38), (37), (37), (33), (31), (31), (9), (7), (5), (5), (5), (5), (5), (5), (5), (5), (5), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(311), (277), (264), (100), (74), (73), (67), (41), (37), (34), (6), (6), (6), (5), (3), (3), (2), (2), (1)
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Product Details anti-IKBKB Antibody

Target Details IKBKB Application Details Handling Images
Specificity This phosphorylation site is homologous across the listed species.
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic phosphopeptide derived from human IKK beta around the phosphorylation site of Tyr199
Isotype IgG

Target Details IKBKB

Product Details anti-IKBKB Antibody Application Details Handling Images back to top
Antigen
Alternative Name Ikk beta (IKBKB Antibody Abstract)
Background

Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.

Subcellular location: Cytoplasm, Nucleus


Synonyms: IKK2, IKKB, IMD15, NFKBIKB, IKK-beta, Inhibitor of nuclear factor kappa-B kinase subunit beta, I-kappa-B-kinase beta, IKK-B, IkBKB, I-kappa-B kinase 2, Nuclear factor NF-kappa-B inhibitor kinase beta
Gene ID 3551
UniProt O14920
Research Area Immunology, Innate Immunity, Atherosclerosis, Apoptosis/Necrosis, Transcription Factors
Pathways NF-kappaB Signaling, RTK Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Hepatitis C, Toll-Like Receptors Cascades

Application Details

Product Details anti-IKBKB Antibody Target Details IKBKB Handling Images back to top
Application Notes WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
Restrictions For Research Use only

Handling

Product Details anti-IKBKB Antibody Target Details IKBKB Application Details Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

Images

Product Details anti-IKBKB Antibody Target Details IKBKB Application Details Handling back to top
Supplier Images
SDS-PAGE (SDS) image for anti-IKBKB antibody (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta) (AA 180-230) (ABIN743243) Lane 1: mouse brain lysates Lane 2: mouse lung lysates probed with Anti phospho-IKK b...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-IKBKB antibody (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta) (AA 180-230) (ABIN743243) Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti-IKK beta(Tyr1...