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anti-Human IKBKB antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended IKBKB Antibody (supplied by: Log in to see )

Antigen
Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB) Antibodies
  • AI132552
  • AIM-1
  • anon-89Bd
  • CG4201
  • DIK
  • dIKK
  • dIKK-beta
  • dIKKbeta
  • DLAK
  • dLak
  • Dmel\\CG4201
  • DmIKK
  • Dmikkb
  • DmIKKb
  • DmIkkbeta
  • dmIKKbeta
  • Dmikkbeta
  • DmIKKbeta
  • DmIKKBeta
  • Ik
  • IK
  • IKBKB
  • ikk
  • IKK
  • IKK-2
  • IKK-beta
  • ikk-beta
  • ikk2
  • IKK2
  • Ikkb
  • IKKB
  • IKKb
  • ikkb
  • ikkbeta
  • Ikkbeta
  • IKKbeta
  • IKK[b]
  • ird
  • IRD-5
  • Ird-5
  • Ird5
  • IRD5
  • ird5/DmIkk[beta]
  • Lak
  • LRK
  • NFKBIKB
Epitope
AA 180-230, pTyr199
47
32
26
21
21
21
20
20
20
20
19
19
19
19
19
19
19
14
14
14
12
9
8
8
7
6
6
6
6
6
6
6
6
6
6
6
6
6
6
6
6
6
5
5
5
4
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
642
191
125
16
10
2
2
1
1
Host
Rabbit
549
107
9
2
Clonality
Polyclonal
Conjugate
This IKBKB antibody is un-conjugated
38
36
36
33
31
31
9
7
5
5
5
5
5
5
5
2
2
2
2
2
2
2
2
2
2
2
2
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
300
273
264
105
69
57
57
49
39
20
6
5
4
3
3
2
1
1
Supplier
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Catalog No. ABIN743243
$ 291.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.34288716 ABIN213937 ICC IHC (p) WB Rabbit C-Term Log in to see Polyclonal
0.34288716 ABIN218607 IF IHC (p) IP ELISA WB Rabbit C-Term Log in to see Polyclonal
0.34288716 ABIN297183 IHC (p) WB Chicken IgY AA 310-376 Log in to see Polyclonal
0.0008982679 ABIN271895 IHC (p) WB Rabbit Log in to see Polyclonal
0.0008982679 ABIN272025 IHC (p) WB Rabbit Log in to see Polyclonal
0.0008982679 ABIN1882097 IF IHC (p) WB Rabbit Log in to see Polyclonal 8
0.0008982679 ABIN2878951 IHC (p) ELISA Rabbit IgG AA 166-215 Log in to see Polyclonal
0.0008982679 ABIN2856162 ICC IF IHC (p) WB Rabbit IgG C-Term Log in to see Polyclonal
0.0008982679 ABIN400933 IHC (p) WB Chicken Ig AA 310-376 Log in to see Polyclonal
0.0008982679 ABIN3042734 IHC (p) WB Rabbit IgG AA 398-756 Log in to see Polyclonal
0.0008982679 ABIN1107724 IHC (p) WB Mouse IgG1 Log in to see 10A2C5B3 1
0.0008982679 ABIN269739 IHC (p) IHC ELISA WB Rabbit IgG C-Term Log in to see Polyclonal 1
0.0008982679 ABIN302820 IF IHC (p) WB Rabbit Log in to see Polyclonal
0.0008982679 ABIN230660 IHC (p) ELISA WB Mouse IgG1 Log in to see
0.0008982679 ABIN303371 EIA IF IHC (p) IP WB Rabbit C-Term Log in to see Polyclonal
0.0008982679 ABIN1833195 ICC IHC (p) WB Rabbit IgG AA 493-739 Log in to see Polyclonal
0.0008982679 ABIN743245 IHC (p) WB Biotin Rabbit IgG AA 180-230, pTyr199 Log in to see Polyclonal
0.0008982679 ABIN743252 IHC (p) WB HRP Rabbit IgG AA 180-230, pTyr199 Log in to see Polyclonal
0.0008982679 ABIN2623788 IHC (p) WB Rabbit IgG AA 398-756 Log in to see Polyclonal
0.0008982679 ABIN801492 IHC (p) WB HRP Rabbit IgG pSer471 Log in to see Polyclonal

Top referenced anti-IKBKB antibody for Immunohistochemistry (Paraffin-embedded Sections)

Similar anti-IKBKB Antibodies

Application / Reactivity Rat (Rattus) Mouse (Murine)
ELISA 21 Antibodies 38 Antibodies
Enzyme Immunoassay (EIA) 1 Antibodies 1 Antibodies
Immunochromatography (IC) 1 Antibodies 1 Antibodies
Immunocytochemistry (ICC) 4 Antibodies 6 Antibodies
Immunofluorescence (IF) 15 Antibodies 18 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 45 Antibodies
Immunohistochemistry (IHC) 37 Antibodies
Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp)) 1 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 23 Antibodies
Immunoprecipitation (IP) 3 Antibodies
Western Blotting (WB) 62 Antibodies
Dot Blot (DB) 21 Antibodies
Flow Cytometry (FACS) 37 Antibodies

General

Antigen Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB) Antibodies
Epitope AA 180-230, pTyr199
(47), (32), (26), (21), (21), (21), (20), (20), (20), (20), (19), (19), (19), (19), (19), (19), (19), (14), (14), (14), (12), (9), (8), (8), (7), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (5), (5), (5), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(642), (191), (125), (16), (10), (2), (2), (1), (1)
Host Rabbit
(549), (107), (9), (2)
Clonality
Polyclonal
Conjugate This IKBKB antibody is un-conjugated
(38), (36), (36), (33), (31), (31), (9), (7), (5), (5), (5), (5), (5), (5), (5), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(300), (273), (264), (105), (69), (57), (57), (49), (39), (20), (6), (5), (4), (3), (3), (2), (1), (1)
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Product Details anti-IKBKB Antibody

Target Details IKBKB Application Details Handling Images
Specificity This phosphorylation site is homologous across the listed species.
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic phosphopeptide derived from human IKK beta around the phosphorylation site of Tyr199
Isotype IgG

Target Details IKBKB

Product Details anti-IKBKB Antibody Application Details Handling Images back to top
Antigen
Alternative Name Ikk beta (IKBKB Antibody Abstract)
Background

Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.

Subcellular location: Cytoplasm, Nucleus


Synonyms: IKK2, IKKB, IMD15, NFKBIKB, IKK-beta, Inhibitor of nuclear factor kappa-B kinase subunit beta, I-kappa-B-kinase beta, IKK-B, IkBKB, I-kappa-B kinase 2, Nuclear factor NF-kappa-B inhibitor kinase beta
Gene ID 3551
UniProt O14920
Research Area Immunology, Innate Immunity, Atherosclerosis, Apoptosis/Necrosis, Transcription Factors
Pathways NF-kappaB Signaling, RTK Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway

Application Details

Product Details anti-IKBKB Antibody Target Details IKBKB Handling Images back to top
Application Notes WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
Restrictions For Research Use only

Handling

Product Details anti-IKBKB Antibody Target Details IKBKB Application Details Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

Images

Product Details anti-IKBKB Antibody Target Details IKBKB Application Details Handling back to top
Supplier Images
SDS-PAGE (SDS) image for anti-IKBKB antibody (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta) (AA 180-230) (ABIN743243) Lane 1: mouse brain lysates Lane 2: mouse lung lysates probed with Anti phospho-IKK b...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-IKBKB antibody (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta) (AA 180-230) (ABIN743243) Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti-IKK beta(Tyr1...