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Browse our anti-IKBKG (IKBKG) Antibodies

Full name:
anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma Antibodies (IKBKG)
On www.antibodies-online.com are 269 Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) Antibodies from 28 different suppliers available. Additionally we are shipping IKBKG Kits (12) and IKBKG Proteins (11) and many more products for this protein. A total of 310 IKBKG products are currently listed.
Synonyms:
1110037D23Rik, AI848108, AI851264, AMCBX1, AW124339, CG16910, dIKK, dIKK-gamma, Dmel\\CG16910, DmIKK-gamma, dmIKKgamma, FIP-3, FIP3, Fip3p, fj33c07, IKBKG, IKBKG_1, IKBKG_2, IKK, IKK-gamma, IKKg, IKKgamma, IKK[g], IKK[[gamma]], IP, IP1, IP2, IPD2, Kenny, Key, MGC97885, Nemo, wu:fj33c07, ZC2HC9, zgc:113492
list all antibodies Gene Name GeneID UniProt
IKBKG 8517 Q9Y6K9
IKBKG 309295 Q6TMG5
IKBKG 16151 O88522

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All available anti-IKBKG Antibodies

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Top referenced anti-IKBKG Antibodies

  1. Human Monoclonal IKBKG Primary Antibody for WB - ABIN387828 : Mooster, Cancrini, Simonetti, Rossi, Di Matteo, Romiti, Di Cesare, Notarangelo, Geha, McDonald: Immune deficiency caused by impaired expression of nuclear factor-kappaB essential modifier (NEMO) because of a mutation in the 5' untranslated region of the NEMO gene. in The Journal of allergy and clinical immunology 2010 (PubMed)
    Show all 6 references for ABIN387828

  2. Dog (Canine) Monoclonal IKBKG Primary Antibody for IF, WB - ABIN968464 : Chu, Shin, Yang, DiDonato, Ballard: IKKgamma mediates the interaction of cellular IkappaB kinases with the tax transforming protein of human T cell leukemia virus type 1. in The Journal of biological chemistry 1999 (PubMed)
    Show all 5 references for ABIN968464

  3. Human Monoclonal IKBKG Primary Antibody for IHC (p), IP - ABIN567775 : Iha, Kibler, Yedavalli, Peloponese, Haller, Miyazato, Kasai, Jeang: Segregation of NF-kappaB activation through NEMO/IKKgamma by Tax and TNFalpha: implications for stimulus-specific interruption of oncogenic signaling. in Oncogene 2003 (PubMed)
    Show all 2 references for ABIN567775

  4. Human Polyclonal IKBKG Primary Antibody for IF, ELISA - ABIN1532742 : Rothwarf, Zandi, Natoli, Karin: IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex. in Nature 1998 (PubMed)

  5. Human Polyclonal IKBKG Primary Antibody for ELISA, WB - ABIN1534228 : Xiao, Sun: Activation of IKKalpha and IKKbeta through their fusion with HTLV-I tax protein. in Oncogene 2000 (PubMed)

  6. Cow (Bovine) Polyclonal IKBKG Primary Antibody for WB - ABIN2779232 : Hai, Yeung, Wood, Wei, Yamaoka, Gatalica, Jeang, Brasier: An alternative splice product of IkappaB kinase (IKKgamma), IKKgamma-delta, differentially mediates cytokine and human T-cell leukemia virus type 1 tax-induced NF-kappaB activation. in Journal of virology 2006 (PubMed)

  7. Cow (Bovine) Polyclonal IKBKG Primary Antibody for WB - ABIN2779233 : Salminen, Suuronen, Huuskonen, Kaarniranta: NEMO shuttle: a link between DNA damage and NF-kappaB activation in progeroid syndromes? in Biochemical and biophysical research communications 2008 (PubMed)

More Antibodies against IKBKG Interaction Partners

Human Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) interaction partners

  1. Deletion of exons 4 to 10 (NEMODelta4-10) accounts for about 80% of cases (familial and sporadic) of Incontinentia pigmenti.

  2. results further reveal that cFLIPLrequires the linear ubiquitin chain assembly complex and the kinase TAK1 (show MAP3K7 Antibodies) for activation of the IKK (show CHUK Antibodies) kinase

  3. USP18 (show USP18 Antibodies) negatively regulates NF-kappaB (show NFKB1 Antibodies) signaling by targeting TAK1 (show MAP3K7 Antibodies) and NEMO for deubiquitination through distinct mechanisms.

  4. A missense mutation in IKBKG causes a Nager syndrome or an atypical incontinentia pigmenti phenotype. IKBKG mutations are typically associated with preterm male death, but this variant is associated with survival for 8-15 days.

  5. Recruitment of A20 (show TNFAIP3 Antibodies) to the C-terminal domain of NEMO represents a novel mechanism limiting NF-kappaB (show NFKB1 Antibodies) activation by NEMO, and its absence results in autoinflammatory disease.

  6. Authors show that Rab11 (show RAB11A Antibodies)-GMPPNP-FIP3-Rabin8 (show RAB3IP Antibodies) is more stable than Rab11 (show RAB11A Antibodies)-GMPPNP-Rabin8 (show RAB3IP Antibodies), owing to direct interaction between Rabin8 (show RAB3IP Antibodies) and FIP3 within the dual effector-bound complex.

  7. Somatic mosaicism of a novel IKBKG nonsense mutation in a male patient with incontinentia pigmenti.

  8. COMMD7 (show COMMD7 Antibodies)'s binding to NEMO does not interfere with the binding to the IKKs, and that the disruption of the IKK (show CHUK Antibodies) complex through the use of the NBP (show NUBP1 Antibodies) competitor impairs the termination of NF-kappaB (show NFKB1 Antibodies) activity

  9. findings suggest that rare, functional variants in MYD88, IRAK4 or IKBKG do not significantly contribute to IPD susceptibility in adults at the population level

  10. the incontinentia pigmenti patients presented a common IKBKG exon 4-10 deletion

Pig (Porcine) Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) interaction partners

  1. Nsp4 interfered with the NF-kappaB (show NFKB1 Antibodies) signaling pathway through the cleavage of IKBKG at the E349-S350 site, leading to the downregulation of IFN-beta (show IFNB1 Antibodies) production.

  2. Foot-and-mouth disease virus 3C protease cleaves NEMO to impair innate immune signaling.

Mouse (Murine) Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) interaction partners

  1. prevents colon inflammation by NF-kappaB (show NFKB1 Antibodies)-independent functions

  2. Thyrocyte-specific NEMO knock-out mice gradually develop hypothyroidism after birth, which leads to reduced body weight and shortened life span.

  3. SENP1 (show SENP1 Antibodies) deletion in adipocytes causes Type 1 diabetes mellitus via enhanced SUMOylation of NEMO, leading to increased NF-kappaB (show NFKB1 Antibodies) activity, cytokine production and pancreatic inflammation.

  4. Crucial functions of inflammatory TAK1 (show NR2C2 Antibodies)-NEMO signaling in protecting the brain endothelium and maintaining normal brain function.

  5. Data show that NEMO protein prevents hepatocarcinogenesis by inhibiting receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1 (show RIPK1 Antibodies)) kinase activity-driven hepatocyte apoptosis.

  6. Data show that the in utero death of NF-NF (show NFASC Antibodies)-kappaB (show NFKB1 Antibodies) essential modulator (NEMO) and cylindromatosis protein double mutant mice is mediated by TNF (show TNF Antibodies) receptor 1 (TNFR1 (show TNFRSF1A Antibodies)) signaling and can be rescued by TNFR1 (show TNFRSF1A Antibodies) deficiency.

  7. signaling through NEMO might not only be involved in the production of NF-kappaB (show NFKB1 Antibodies) proinflammatory chemokines but also regulates podocyte dynamics independently of NF-kappaB (show NFKB1 Antibodies)

  8. The stability of the NEMO coiled coil is maintained by strong interhelix interactions in the region centered on residue 54.

  9. NEMO deficiency results in apoptosis, the development of liver fibrosis and hepatocellular carcinoma, all of which are substantially alleviated by allogeneic hepatocyte transplantation.

  10. Mass spectrometric analysis demonstrated that WA covalently modifies NEMO on a cysteine residue within the C-terminal zinc finger (ZF) domain. Point mutations to the ZF can reverse the WA-induced Lys (show LYZ Antibodies)-48-polyubiquitin (show UBB Antibodies) binding phenotype

IKBKG Antigen Profile

Antigen Summary

This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome.

Alternative names and synonyms associated with IKBKG

  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (ikbkg) antibody
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG) antibody
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (LOC782205) antibody
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG_1) antibody
  • kenny (key) antibody
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (Ikbkg) antibody
  • inhibitor of kappaB kinase gamma (Ikbkg) antibody
  • 1110037D23Rik antibody
  • AI848108 antibody
  • AI851264 antibody
  • AMCBX1 antibody
  • AW124339 antibody
  • CG16910 antibody
  • dIKK antibody
  • dIKK-gamma antibody
  • Dmel\\CG16910 antibody
  • DmIKK-gamma antibody
  • dmIKKgamma antibody
  • FIP-3 antibody
  • FIP3 antibody
  • Fip3p antibody
  • fj33c07 antibody
  • IKBKG antibody
  • IKBKG_1 antibody
  • IKBKG_2 antibody
  • IKK antibody
  • IKK-gamma antibody
  • IKKg antibody
  • IKKgamma antibody
  • IKK[g] antibody
  • IKK[[gamma]] antibody
  • IP antibody
  • IP1 antibody
  • IP2 antibody
  • IPD2 antibody
  • Kenny antibody
  • Key antibody
  • MGC97885 antibody
  • Nemo antibody
  • wu:fj33c07 antibody
  • ZC2HC9 antibody
  • zgc:113492 antibody

Protein level used designations for IKBKG

NF-kappa-B essential modulator , ikky , inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma , inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, isoform 1 , inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, isoform 2 , NF-kappa-B essential modulator-like , CG16910-PA , CG16910-PB , key-PA , key-PB , I-kappa-B kinase subunit gamma , IKKAP1 , IKKG , IkB kinase gamma subunit , NF-kappa-B essential modifier , NFkappaB essential modulator , ikB kinase subunit gamma , ikB kinase-associated protein 1 , incontinentia pigmenti , inhibitor of nuclear factor kappa-B kinase subunit gamma , I-kappa-B kinase gamma , IKK-gamma , NEMO , NF-kappa B essential modulator , inhibitor of kappaB kinase gamma , mFIP-3

GENE ID SPECIES
541530 Danio rerio
701237 Macaca mulatta
735069 Xenopus laevis
743415 Pan troglodytes
782205 Bos taurus
100137553 Papio anubis
100145270 Xenopus (Silurana) tropicalis
100470223 Ailuropoda melanoleuca
37967 Drosophila melanogaster
8517 Homo sapiens
612576 Canis lupus familiaris
100127355 Sus scrofa
281855 Bos taurus
100328905 Oryctolagus cuniculus
309295 Rattus norvegicus
16151 Mus musculus
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