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anti-Dog (Canine) IKBKG antibody for Immunofluorescence

Recommended IKBKG Antibody (supplied by: Log in to see )

Antigen
Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) Antibodies
  • 1110037D23Rik
  • AI848108
  • AI851264
  • AMCBX1
  • AW124339
  • CG16910
  • dIKK
  • dIKK-gamma
  • Dmel\\CG16910
  • DmIKK-gamma
  • dmIKKgamma
  • Dmikkgamma
  • DmIKKgamma
  • FIP-3
  • FIP3
  • Fip3p
  • fj33c07
  • IKBKG
  • IKBKG_1
  • IKBKG_2
  • IKK
  • IKK-gamma
  • IKKg
  • IKKgamma
  • IKK[g]
  • IKK[[gamma]]
  • IP
  • IP1
  • IP2
  • IPD2
  • Kenny
  • Key
  • KEY
  • MGC97885
  • nemo
  • Nemo
  • NEMO
  • wu:fj33c07
  • ZC2HC9
  • zgc:113492
Epitope
AA 278-396
31
29
28
17
13
11
11
9
8
7
6
5
5
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Dog (Canine), Human, Rat (Rattus)
307
96
63
5
4
3
2
2
2
2
2
2
1
1
Host
Mouse
222
91
2
2
1
Clonality
Monoclonal
Conjugate
This IKBKG antibody is un-conjugated
11
10
8
6
6
6
4
4
4
4
4
4
4
4
4
2
2
2
2
2
2
2
2
2
2
2
2
Application
Immunofluorescence (IF), Western Blotting (WB)
243
113
73
45
43
38
25
23
5
4
3
1
1
1
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Catalog No. ABIN968464
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Top referenced anti-IKBKG antibody for Immunofluorescence

Similar anti-IKBKG Antibodies

Application / Reactivity Human Dog (Canine) Rat (Rattus)
Western Blotting (WB) 236 Antibodies 4 Antibodies 38 Antibodies
Proximity Ligation Assay (PLA) 1 Antibodies
Intracellular Staining (ICS) 1 Antibodies
Immunoprecipitation (IP) 5 Antibodies 3 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 46 Antibodies 11 Antibodies
Immunohistochemistry (IHC) 72 Antibodies 15 Antibodies 1 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 45 Antibodies 22 Antibodies
Immunofluorescence (IF) 37 Antibodies 9 Antibodies 1 Antibodies
Immunocytochemistry (ICC) 27 Antibodies 11 Antibodies
Immunochromatography (IC) 4 Antibodies

General

Antigen Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) Antibodies
Epitope AA 278-396
(31), (29), (28), (17), (13), (11), (11), (9), (8), (7), (6), (5), (5), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Dog (Canine), Human, Rat (Rattus)
(307), (96), (63), (5), (4), (3), (2), (2), (2), (2), (2), (2), (1), (1)
Host Mouse
(222), (91), (2), (2), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This IKBKG antibody is un-conjugated
(11), (10), (8), (6), (6), (6), (4), (4), (4), (4), (4), (4), (4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application Immunofluorescence (IF), Western Blotting (WB)
(243), (113), (73), (45), (43), (38), (25), (23), (5), (4), (3), (1), (1), (1)
Pubmed 5 references available
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Product Details anti-IKBKG Antibody

Target Details IKBKG Application Details Handling References for anti-IKBKG Antibody (ABIN968464) Images
Cross-Reactivity Rat (Rattus), Human, Dog (Canine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Immunogen Mouse IKKgamma/NEMO aa. 278-396
Clone 54-IKKgamma-NEMO
Isotype IgG1

Target Details IKBKG

Product Details anti-IKBKG Antibody Application Details Handling References for anti-IKBKG Antibody (ABIN968464) Images back to top
Antigen
Alternative Name IKK gamma (IKBKG Antibody Abstract)
Background In most cells, NF-kappaB is sequestered in an inactive cytoplasmic form via interactions with the inhibitory proteins IkappaBalpha, IkappaBbeta, and IkappaBepsilon. Cell stimulation induces the release, activation, and nuclear translocation of NF-kappaB. Release of NF-kappaB results from the phosphorylation and subsequent proteolytic degradation of the IkappaB proteins. Two cytokine-inducible IkappaB kinases (IKKalpha and IKKbeta) phosphorylate and target the IkappaB proteins for degradation by the ubiquitin pathway. These kinases are components of a 700-900 kDa multisubunit complex that also contains NF-kappaB/RelA, IkappaBalpha, MEKK1, NIK, IKAP, and IKKgamma/NEMO (NF-kappaB essential modulator). IKKgamma contains two coiled-coil domains and a leucine zipper which allow it to form dimers and trimers that interact directly with IKKbeta. IKKgamma, essential for IKKalpha/IKKbeta activation of NF-kappaB, is located functionally and physically upstream of these subunits. In addition, IKKgamma enables the HTLV-1 Tax oncoprotein to interact with IKKbeta, resulting in constitutive activation of NF-kappaB and maintenance of cellular transformation. Thus, IKKgamma is an essential element of the IkappaB complex and an adaptor that mediates stable formation of Tax-IKK complexes.
Synonyms: NEMO
Molecular Weight 48 kDa
Research Area Immunology, Innate Immunity, Atherosclerosis, Apoptosis/Necrosis, Transcription Factors
Pathways NF-kappaB Signaling, RTK Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway

Application Details

Product Details anti-IKBKG Antibody Target Details IKBKG Handling References for anti-IKBKG Antibody (ABIN968464) Images back to top
Comment

Related Products: ABIN968547, ABIN967389

Restrictions For Research Use only

Handling

Product Details anti-IKBKG Antibody Target Details IKBKG Application Details References for anti-IKBKG Antibody (ABIN968464) Images back to top
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20° C.

References for anti-IKBKG Antibody (ABIN968464)

Product Details anti-IKBKG Antibody Target Details IKBKG Application Details Handling Images back to top
Product cited in:

Weil, Schwamborn, Alcover, Bessia, Di Bartolo, Israël: "Induction of the NF-kappaB cascade by recruitment of the scaffold molecule NEMO to the T cell receptor." in: Immunity, Vol. 18, Issue 1, pp. 13-26, 2003

Chu, Shin, Yang, DiDonato, Ballard: "IKKgamma mediates the interaction of cellular IkappaB kinases with the tax transforming protein of human T cell leukemia virus type 1." in: The Journal of biological chemistry, Vol. 274, Issue 22, pp. 15297-300, 1999

Jin, Giordano, Kibler, Nakano, Jeang: "Role of adapter function in oncoprotein-mediated activation of NF-kappaB. Human T-cell leukemia virus type I Tax interacts directly with IkappaB kinase gamma." in: The Journal of biological chemistry, Vol. 274, Issue 25, pp. 17402-5, 1999

Rothwarf, Zandi, Natoli, Karin: "IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex." in: Nature, Vol. 395, Issue 6699, pp. 297-300, 1998

Yamaoka, Courtois, Bessia, Whiteside, Weil, Agou, Kirk, Kay, Israël: "Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation." in: Cell, Vol. 93, Issue 7, pp. 1231-40, 1998

Images

Product Details anti-IKBKG Antibody Target Details IKBKG Application Details Handling References for anti-IKBKG Antibody (ABIN968464) back to top
Supplier Images
Western Blotting (WB) image for anti-IKBKG antibody (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma) (AA 278-396) (ABIN968464) Western blot analysis of IKKgamma on rat kidney lysate. Lane 1: 1:250, lane 2: 1:500,...
Immunofluorescence (IF) image for anti-IKBKG antibody (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma) (AA 278-396) (ABIN968464) Immunofluorescent staining of ES2 cells with anti-IKKgamma antibody.
 image for anti-IKBKG antibody (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma) (AA 278-396) (ABIN968464) anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) (AA 278-396) antibody (Image 3)
Western Blotting (WB) image for anti-IKBKG antibody (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma) (AA 278-396) (ABIN968464) anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) (AA 278-396) antibody (Image 4)