Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all species
Show all synonyms
Select your species
Results show that NEMO's expression is regulated by ASAP3 (show ASAP3 ELISA Kits) which it interacts directly with it reducing its poly-ubiquitinylation.
E+P treatment of breast cancer cells increased ER binding to the NEMO promoter, thereby increasing NEMO expression.
Hematopoietic stem cell transplantation can cure most clinical features of patients with a variety of IKBKG mutations.
Authors show that NEMO stabilizes HIFalpha via direct interaction and independently of NF-kappaB (show NFKB1 ELISA Kits) signaling in vitro. NEMO prolongs tumor cell survival via regulation of apoptosis and activation of epithelial-to-mesenchymal transition, facilitating tumor metastasis.
The results demonstrate the the first example of father-to-daughter transmission of IP in which a pathogenic mutation in IKBKG has been demonstrated
Molluscum contagiosum virus MC005 inhibited NF-kappaB (show NFKB1 ELISA Kits) proximal to the IkappaB kinase (show CHUK ELISA Kits) (IKK (show CHUK ELISA Kits)) complex, and unbiased affinity purification revealed that MC005 interacts with the IKK (show CHUK ELISA Kits) subunit NEMO (NF-kappaB (show NFKB1 ELISA Kits) essential modulator).
These data suggest that molluscum contagiosum virus MC159 competitively binds to NEMO to prevent cIAP1 (show BIRC2 ELISA Kits)-induced NEMO polyubiquitination.
High IKBKG expression is associated with multiple myeloma.
Our findings shed light on the nature of the interaction between NEMO and poly-ubiquitin, suggesting that NEMO is differentially regulated by poly-ubiquitin chain length and that this regulation occurs via a modulation of the available equilibrium of conformational states, rather than gross structural change
FADD (show FADD ELISA Kits), as well as NEMO, is a substrate for LUBAC ubiquitin ligase (E3) complex, composed of the HOIP (show RNF31 ELISA Kits), HOIL-1L (show RBCK1 ELISA Kits), and SHARPIN (show SHARPIN ELISA Kits) subunits.
Porcine deltacoronavirus nsp5, the 3C-like protease, inhibits interferon-beta (show IFNB1 ELISA Kits) production through the cleavage of NEMO.
Nsp4 interfered with the NF-kappaB (show NFKB1 ELISA Kits) signaling pathway through the cleavage of IKBKG at the E349-S350 site, leading to the downregulation of IFN-beta (show IFNB1 ELISA Kits) production.
Foot-and-mouth disease virus 3C protease cleaves NEMO to impair innate immune signaling.
This study provides evidence for a protective function of canonical IKK (show CHUK ELISA Kits)/NF-kappaB (show NFKB1 ELISA Kits) signalling in the arenchymal compartment during pancreatitis. In the absence of the regulatory IKK (show CHUK ELISA Kits) subunit NEMO, a combination of a fibrogenic gene signature, enhanced acinar-ductal metaplasia and a lack of regeneration contribute to the exacerbation of pancreatitis.
robust caspase (show CASP3 ELISA Kits) activation in NEMO-deficient cells is concomitant with RIPK3 (show RIPK3 ELISA Kits) recruitment to the apoptosis-mediating complex.
lymphocyte-specific deletion of IKK2 (show IKBKB ELISA Kits) or NEMO aggravated kidney injury after ischemia-reperfusion injury, and, in both conditions, the percentage of Th17 cells was increased.
Whereas Parkin (show PARK2 ELISA Kits) has been reported to positively regulate the expression of OPA1 (show MED12 ELISA Kits) through NEMO, herein we found that PARK2 (show PARK2 ELISA Kits) overexpression did not modify the expression of OPA1 (show MED12 ELISA Kits).
prevents colon inflammation by NF-kappaB (show NFKB1 ELISA Kits)-independent functions
Thyrocyte-specific NEMO knock-out mice gradually develop hypothyroidism after birth, which leads to reduced body weight and shortened life span.
SENP1 (show SENP1 ELISA Kits) deletion in adipocytes causes Type 1 diabetes mellitus via enhanced SUMOylation of NEMO, leading to increased NF-kappaB (show NFKB1 ELISA Kits) activity, cytokine production and pancreatic inflammation.
Crucial functions of inflammatory TAK1 (show NR2C2 ELISA Kits)-NEMO signaling in protecting the brain endothelium and maintaining normal brain function.
Data show that NEMO protein prevents hepatocarcinogenesis by inhibiting receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1 (show RIPK1 ELISA Kits)) kinase activity-driven hepatocyte apoptosis.
This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome.
NF-kappa-B essential modulator
, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, isoform 1
, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, isoform 2
, NF-kappa-B essential modulator-like
, I-kappa-B kinase subunit gamma
, IkB kinase gamma subunit
, NF-kappa-B essential modifier
, NFkappaB essential modulator
, ikB kinase subunit gamma
, ikB kinase-associated protein 1
, incontinentia pigmenti
, inhibitor of nuclear factor kappa-B kinase subunit gamma
, I-kappa-B kinase gamma
, NF-kappa B essential modulator
, inhibitor of kappaB kinase gamma