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Browse our IKBKG Proteins (IKBKG)

Full name:
Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma Proteins (IKBKG)
On www.antibodies-online.com are 11 Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) Proteins from 5 different suppliers available. Additionally we are shipping IKBKG Antibodies (319) and IKBKG Kits (12) and many more products for this protein. A total of 361 IKBKG products are currently listed.
Synonyms:
1110037D23Rik, AI848108, AI851264, AMCBX1, AW124339, CG16910, dIKK, dIKK-gamma, Dmel\\CG16910, DmIKK-gamma, dmIKKgamma, FIP-3, FIP3, Fip3p, fj33c07, IKBKG, IKBKG_1, IKBKG_2, IKK, IKK-gamma, IKKg, IKKgamma, IKK[g], IKK[[gamma]], IP, IP1, IP2, IPD2, Kenny, Key, MGC97885, Nemo, wu:fj33c07, ZC2HC9, zgc:113492
list all proteins Gene Name GeneID UniProt
IKBKG 8517 Q9Y6K9
IKBKG 309295 Q6TMG5
IKBKG 16151 O88522

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IKBKG Proteins (IKBKG) by Origin

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More Proteins for IKBKG Interaction Partners

Human Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) interaction partners

  1. Herein, our simulations of the zinc finger NEMO (2JVX) using multiple simulations of length 15, 30, 1000, and 3000 ns are analyzed to provide clarity on this point.

  2. Deletion of exons 4 to 10 (NEMODelta4-10) accounts for about 80% of cases (familial and sporadic) of Incontinentia pigmenti.

  3. results further reveal that cFLIPLrequires the linear ubiquitin chain assembly complex and the kinase TAK1 (show MAP3K7 Proteins) for activation of the IKK (show CHUK Proteins) kinase

  4. USP18 (show USP18 Proteins) negatively regulates NF-kappaB (show NFKB1 Proteins) signaling by targeting TAK1 (show MAP3K7 Proteins) and NEMO for deubiquitination through distinct mechanisms.

  5. A missense mutation in IKBKG causes a Nager syndrome or an atypical incontinentia pigmenti phenotype. IKBKG mutations are typically associated with preterm male death, but this variant is associated with survival for 8-15 days.

  6. Recruitment of A20 (show TNFAIP3 Proteins) to the C-terminal domain of NEMO represents a novel mechanism limiting NF-kappaB (show NFKB1 Proteins) activation by NEMO, and its absence results in autoinflammatory disease.

  7. Authors show that Rab11 (show RAB11A Proteins)-GMPPNP-FIP3-Rabin8 is more stable than Rab11 (show RAB11A Proteins)-GMPPNP-Rabin8, owing to direct interaction between Rabin8 and FIP3 within the dual effector-bound complex.

  8. Somatic mosaicism of a novel IKBKG nonsense mutation in a male patient with incontinentia pigmenti.

  9. COMMD7 (show COMMD7 Proteins)'s binding to NEMO does not interfere with the binding to the IKKs, and that the disruption of the IKK (show CHUK Proteins) complex through the use of the NBP (show NUBP1 Proteins) competitor impairs the termination of NF-kappaB (show NFKB1 Proteins) activity

  10. findings suggest that rare, functional variants in MYD88, IRAK4 or IKBKG do not significantly contribute to IPD susceptibility in adults at the population level

Pig (Porcine) Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) interaction partners

  1. Nsp4 interfered with the NF-kappaB (show NFKB1 Proteins) signaling pathway through the cleavage of IKBKG at the E349-S350 site, leading to the downregulation of IFN-beta (show IFNB1 Proteins) production.

  2. Foot-and-mouth disease virus 3C protease cleaves NEMO to impair innate immune signaling.

Mouse (Murine) Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) interaction partners

  1. Whereas Parkin (show PARK2 Proteins) has been reported to positively regulate the expression of OPA1 through NEMO, herein we found that PARK2 (show PARK2 Proteins) overexpression did not modify the expression of OPA1.

  2. prevents colon inflammation by NF-kappaB (show NFKB1 Proteins)-independent functions

  3. Thyrocyte-specific NEMO knock-out mice gradually develop hypothyroidism after birth, which leads to reduced body weight and shortened life span.

  4. SENP1 (show SENP1 Proteins) deletion in adipocytes causes Type 1 diabetes mellitus via enhanced SUMOylation of NEMO, leading to increased NF-kappaB (show NFKB1 Proteins) activity, cytokine production and pancreatic inflammation.

  5. Crucial functions of inflammatory TAK1 (show NR2C2 Proteins)-NEMO signaling in protecting the brain endothelium and maintaining normal brain function.

  6. Data show that NEMO protein prevents hepatocarcinogenesis by inhibiting receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1 (show RIPK1 Proteins)) kinase activity-driven hepatocyte apoptosis.

  7. Data show that the in utero death of NF-NF (show NFASC Proteins)-kappaB (show NFKB1 Proteins) essential modulator (NEMO) and cylindromatosis protein double mutant mice is mediated by TNF (show TNF Proteins) receptor 1 (TNFR1 (show TNFRSF1A Proteins)) signaling and can be rescued by TNFR1 (show TNFRSF1A Proteins) deficiency.

  8. signaling through NEMO might not only be involved in the production of NF-kappaB (show NFKB1 Proteins) proinflammatory chemokines but also regulates podocyte dynamics independently of NF-kappaB (show NFKB1 Proteins)

  9. The stability of the NEMO coiled coil is maintained by strong interhelix interactions in the region centered on residue 54.

  10. NEMO deficiency results in apoptosis, the development of liver fibrosis and hepatocellular carcinoma, all of which are substantially alleviated by allogeneic hepatocyte transplantation.

IKBKG Protein Profile

Protein Summary

This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome.

Alternative names and synonyms associated with IKBKG

  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (ikbkg)
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG)
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (LOC782205)
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG_1)
  • kenny (key)
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (Ikbkg)
  • inhibitor of kappaB kinase gamma (Ikbkg)
  • 1110037D23Rik protein
  • AI848108 protein
  • AI851264 protein
  • AMCBX1 protein
  • AW124339 protein
  • CG16910 protein
  • dIKK protein
  • dIKK-gamma protein
  • Dmel\\CG16910 protein
  • DmIKK-gamma protein
  • dmIKKgamma protein
  • FIP-3 protein
  • FIP3 protein
  • Fip3p protein
  • fj33c07 protein
  • IKBKG protein
  • IKBKG_1 protein
  • IKBKG_2 protein
  • IKK protein
  • IKK-gamma protein
  • IKKg protein
  • IKKgamma protein
  • IKK[g] protein
  • IKK[[gamma]] protein
  • IP protein
  • IP1 protein
  • IP2 protein
  • IPD2 protein
  • Kenny protein
  • Key protein
  • MGC97885 protein
  • Nemo protein
  • wu:fj33c07 protein
  • ZC2HC9 protein
  • zgc:113492 protein

Protein level used designations for IKBKG

NF-kappa-B essential modulator , ikky , inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma , inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, isoform 1 , inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, isoform 2 , NF-kappa-B essential modulator-like , CG16910-PA , CG16910-PB , key-PA , key-PB , I-kappa-B kinase subunit gamma , IKKAP1 , IKKG , IkB kinase gamma subunit , NF-kappa-B essential modifier , NFkappaB essential modulator , ikB kinase subunit gamma , ikB kinase-associated protein 1 , incontinentia pigmenti , inhibitor of nuclear factor kappa-B kinase subunit gamma , I-kappa-B kinase gamma , IKK-gamma , NEMO , NF-kappa B essential modulator , inhibitor of kappaB kinase gamma , mFIP-3

GENE ID SPECIES
541530 Danio rerio
701237 Macaca mulatta
735069 Xenopus laevis
743415 Pan troglodytes
782205 Bos taurus
100137553 Papio anubis
100145270 Xenopus (Silurana) tropicalis
100470223 Ailuropoda melanoleuca
37967 Drosophila melanogaster
8517 Homo sapiens
612576 Canis lupus familiaris
100127355 Sus scrofa
281855 Bos taurus
100328905 Oryctolagus cuniculus
309295 Rattus norvegicus
16151 Mus musculus
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