Browse our IKBKG Proteins (IKBKG)

On www.antibodies-online.com are 11 Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) Proteins from 5 different suppliers available. Additionally we are shipping IKBKG Antibodies (339) and IKBKG Kits (16) and many more products for this protein. A total of 384 IKBKG products are currently listed.
Synonyms:
1110037D23Rik, AI848108, AI851264, AMCBX1, AW124339, CG16910, dIKK, dIKK-gamma, Dmel\\CG16910, DmIKK-gamma, dmIKKgamma, FIP-3, FIP3, Fip3p, fj33c07, IKBKG, IKBKG_1, IKBKG_2, IKK, IKK-gamma, IKKg, IKKgamma, IKK[g], IKK[[gamma]], IP, IP1, IP2, IPD2, Kenny, Key, MGC97885, Nemo, wu:fj33c07, ZC2HC9, zgc:113492
list all proteins Gene Name GeneID UniProt
IKBKG 8517 Q9Y6K9
IKBKG 309295 Q6TMG5
IKBKG 16151 O88522

IKBKG Proteins (IKBKG) by Origin

More Proteins for IKBKG Interaction Partners

Human Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) interaction partners

  1. Results show that NEMO's expression is regulated by ASAP3 (show ASAP3 Proteins) which it interacts directly with it reducing its poly-ubiquitinylation.

  2. E+P treatment of breast cancer cells increased ER binding to the NEMO promoter, thereby increasing NEMO expression.

  3. Hematopoietic stem cell transplantation can cure most clinical features of patients with a variety of IKBKG mutations.

  4. Authors show that NEMO stabilizes HIFalpha via direct interaction and independently of NF-kappaB (show NFKB1 Proteins) signaling in vitro. NEMO prolongs tumor cell survival via regulation of apoptosis and activation of epithelial-to-mesenchymal transition, facilitating tumor metastasis.

  5. The results demonstrate the the first example of father-to-daughter transmission of IP in which a pathogenic mutation in IKBKG has been demonstrated

  6. Molluscum contagiosum virus MC005 inhibited NF-kappaB (show NFKB1 Proteins) proximal to the IkappaB kinase (show CHUK Proteins) (IKK (show CHUK Proteins)) complex, and unbiased affinity purification revealed that MC005 interacts with the IKK (show CHUK Proteins) subunit NEMO (NF-kappaB (show NFKB1 Proteins) essential modulator).

  7. These data suggest that molluscum contagiosum virus MC159 competitively binds to NEMO to prevent cIAP1 (show BIRC2 Proteins)-induced NEMO polyubiquitination.

  8. High IKBKG expression is associated with multiple myeloma.

  9. Our findings shed light on the nature of the interaction between NEMO and poly-ubiquitin, suggesting that NEMO is differentially regulated by poly-ubiquitin chain length and that this regulation occurs via a modulation of the available equilibrium of conformational states, rather than gross structural change

  10. FADD, as well as NEMO, is a substrate for LUBAC ubiquitin ligase (E3) complex, composed of the HOIP, HOIL-1L, and SHARPIN subunits.

Pig (Porcine) Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) interaction partners

  1. Porcine deltacoronavirus nsp5 (show SPECC1 Proteins), the 3C-like protease, inhibits interferon-beta (show IFNB1 Proteins) production through the cleavage of NEMO.

  2. Nsp4 interfered with the NF-kappaB (show NFKB1 Proteins) signaling pathway through the cleavage of IKBKG at the E349-S350 site, leading to the downregulation of IFN-beta (show IFNB1 Proteins) production.

  3. Foot-and-mouth disease virus 3C protease cleaves NEMO to impair innate immune signaling.

Mouse (Murine) Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) interaction partners

  1. E+P treatment of breast cancer cells increased ER binding to the NEMO promoter, thereby increasing NEMO expression.

  2. robust caspase (show CASP3 Proteins) activation in NEMO-deficient cells is concomitant with RIPK3 (show RIPK3 Proteins) recruitment to the apoptosis-mediating complex.

  3. lymphocyte-specific deletion of IKK2 (show IKBKB Proteins) or NEMO aggravated kidney injury after ischemia-reperfusion injury, and, in both conditions, the percentage of Th17 cells was increased.

  4. Whereas Parkin (show PARK2 Proteins) has been reported to positively regulate the expression of OPA1 through NEMO, herein we found that PARK2 (show PARK2 Proteins) overexpression did not modify the expression of OPA1.

  5. prevents colon inflammation by NF-kappaB (show NFKB1 Proteins)-independent functions

  6. Thyrocyte-specific NEMO knock-out mice gradually develop hypothyroidism after birth, which leads to reduced body weight and shortened life span.

  7. SENP1 (show SENP1 Proteins) deletion in adipocytes causes Type 1 diabetes mellitus via enhanced SUMOylation of NEMO, leading to increased NF-kappaB (show NFKB1 Proteins) activity, cytokine production and pancreatic inflammation.

  8. Crucial functions of inflammatory TAK1 (show NR2C2 Proteins)-NEMO signaling in protecting the brain endothelium and maintaining normal brain function.

  9. Data show that NEMO protein prevents hepatocarcinogenesis by inhibiting receptor (TNFRSF)-interacting serine-threonine kinase 1 (RIPK1 (show RIPK1 Proteins)) kinase activity-driven hepatocyte apoptosis.

  10. Data show that the in utero death of NF-NF (show NFASC Proteins)-kappaB (show NFKB1 Proteins) essential modulator (NEMO) and cylindromatosis protein double mutant mice is mediated by TNF (show TNF Proteins) receptor 1 (TNFR1 (show TNFRSF1A Proteins)) signaling and can be rescued by TNFR1 (show TNFRSF1A Proteins) deficiency.

IKBKG Protein Profile

Protein Summary

This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome.

Alternative names and synonyms associated with IKBKG

  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (ikbkg)
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG)
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (LOC782205)
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG_1)
  • kenny (key)
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (Ikbkg)
  • inhibitor of kappaB kinase gamma (Ikbkg)
  • 1110037D23Rik protein
  • AI848108 protein
  • AI851264 protein
  • AMCBX1 protein
  • AW124339 protein
  • CG16910 protein
  • dIKK protein
  • dIKK-gamma protein
  • Dmel\\CG16910 protein
  • DmIKK-gamma protein
  • dmIKKgamma protein
  • FIP-3 protein
  • FIP3 protein
  • Fip3p protein
  • fj33c07 protein
  • IKBKG protein
  • IKBKG_1 protein
  • IKBKG_2 protein
  • IKK protein
  • IKK-gamma protein
  • IKKg protein
  • IKKgamma protein
  • IKK[g] protein
  • IKK[[gamma]] protein
  • IP protein
  • IP1 protein
  • IP2 protein
  • IPD2 protein
  • Kenny protein
  • Key protein
  • MGC97885 protein
  • Nemo protein
  • wu:fj33c07 protein
  • ZC2HC9 protein
  • zgc:113492 protein

Protein level used designations for IKBKG

NF-kappa-B essential modulator , ikky , inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma , inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, isoform 1 , inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, isoform 2 , NF-kappa-B essential modulator-like , CG16910-PA , CG16910-PB , key-PA , key-PB , I-kappa-B kinase subunit gamma , IKKAP1 , IKKG , IkB kinase gamma subunit , NF-kappa-B essential modifier , NFkappaB essential modulator , ikB kinase subunit gamma , ikB kinase-associated protein 1 , incontinentia pigmenti , inhibitor of nuclear factor kappa-B kinase subunit gamma , I-kappa-B kinase gamma , IKK-gamma , NEMO , NF-kappa B essential modulator , inhibitor of kappaB kinase gamma , mFIP-3

GENE ID SPECIES
541530 Danio rerio
701237 Macaca mulatta
735069 Xenopus laevis
743415 Pan troglodytes
782205 Bos taurus
100137553 Papio anubis
100145270 Xenopus (Silurana) tropicalis
100470223 Ailuropoda melanoleuca
37967 Drosophila melanogaster
8517 Homo sapiens
612576 Canis lupus familiaris
100127355 Sus scrofa
281855 Bos taurus
100328905 Oryctolagus cuniculus
309295 Rattus norvegicus
16151 Mus musculus
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