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Browse our IL1R1 Proteins (IL1R1)

Full name:
Interleukin 1 Receptor, Type I Proteins (IL1R1)
On are 36 Interleukin 1 Receptor, Type I (IL1R1) Proteins from 7 different suppliers available. Additionally we are shipping IL1R1 Antibodies (178) and IL1R1 Kits (20) and many more products for this protein. A total of 250 IL1R1 products are currently listed.
CD121a, CD121b, D2S1473, IL-1R-alpha, IL-iR, IL1R, Il1r-1, IL1RA, P80
list all proteins Gene Name GeneID UniProt
IL1R1 3554 P14778
IL1R1 16177 P13504
IL1R1 25663  

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IL1R1 Proteins (IL1R1) by Origin

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Top referenced IL1R1 Proteins

  1. Rat (Rattus) IL1R1 Protein expressed in Human Cells - ABIN2009063 : Vigers, Anderson, Caffes, Brandhuber: Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta. in Nature 1997 (PubMed)
    Show all 5 references for ABIN2009063

  2. Human IL1R1 Protein expressed in Human Cells - ABIN2002133 : Schreuder, Tardif, Trump-Kallmeyer, Soffientini, Sarubbi, Akeson, Bowlin, Yanofsky, Barrett: A new cytokine-receptor binding mode revealed by the crystal structure of the IL-1 receptor with an antagonist. in Nature 1997 (PubMed)
    Show all 5 references for ABIN2002133

  3. Cynomolgus IL1R1 Protein expressed in Human Cells - ABIN2010085 : Reddy, Huang, Liao: Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 activation. in The Journal of biological chemistry 1997 (PubMed)
    Show all 5 references for ABIN2010085

  4. Cynomolgus IL1R1 Protein expressed in Human Cells - ABIN2010087 : Huang, Gao, Li, Cao: Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein. in Proceedings of the National Academy of Sciences of the United States of America 1998 (PubMed)
    Show all 5 references for ABIN2010087

  5. Mouse (Murine) IL1R1 Protein expressed in Human Cells - ABIN2008322 : Vigers, Dripps, Edwards, Brandhuber: X-ray crystal structure of a small antagonist peptide bound to interleukin-1 receptor type 1. in The Journal of biological chemistry 2001 (PubMed)
    Show all 5 references for ABIN2008322

More Proteins for IL1R1 Interaction Partners

Human Interleukin 1 Receptor, Type I (IL1R1) interaction partners

  1. The results present identification of critical regions within the TIR domain of IL-1 (show IL1A Proteins) receptor type in humans and mice.

  2. IL1R1 (show IL1RN Proteins) SNP rs949963 is associated with the susceptibility to asthma in children from Central China and may increase the serum expression of IL1R1 (show IL1RN Proteins).

  3. Altered expression of EP2 (show SPAG11B Proteins) in patients with aspirin-exacerbated respiratory disease contributes to deficient induction of IL-1RI, reducing the capacity of IL-1beta (show IL1B Proteins) to increase COX-2 and mPGES-1 (show PTGES Proteins) expression, which results in low PGE2 production

  4. investigated the association between four inflammatory cytokines (CD121a, interleukin [IL]-1beta, IL-8 (show IL8 Proteins), and IL-11 (show IL11 Proteins)) and coronary heart disease

  5. This study found that the mRNA expression of IL-1R1, TNFR1 (show TNFRSF1A Proteins), and TNFR2 (show TNFRSF1B Proteins) was significantly higher in schizophreina

  6. IL-1R1 expression appears to define a tissue regulatory T cell phenotype together with the expression of CD25 (show IL2RA Proteins), glucocorticoid-induced tumor necrosis factor (show TNF Proteins) receptor family-related gene and CTLA-4 (show CTLA4 Proteins).

  7. TNF-alpha (show TNF Proteins) (-308) GG, IL-10 (show IL10 Proteins) (-819) TT, IL-10 (show IL10 Proteins) (-1082) GG and IL1R (+1970) CC genotypes are found to be predominant (p=0.01, p=0.02, p=0.0001 and p=0.001, respectively) in both tuberculoid as well as lepromatous leprosy patients.

  8. Single nucleotide polymorphisms in RBPJ (show RBPJ Proteins), IL1R1 (show IL1RN Proteins), REV3L, TRAF3IP2 (show TRAF3IP2 Proteins), IRF1 (show IRF1 Proteins) and ICOS (show CTLA4 Proteins) showed association with rheumatoid arthritis in black South Africans.

  9. IL-1 (show IL1A Proteins) receptor gene polymorphisms could be one of the factors influencing the expression of membrane-bound IL-1 (show IL1A Proteins) receptors on immunocompetent cells.

  10. severe forms of pancreatitis are associated with increased levels of IL-6 (show IL6 Proteins), IL-10 (show IL10 Proteins) and IL-1ra (show IL1RN Proteins)

Mouse (Murine) Interleukin 1 Receptor, Type I (IL1R1) interaction partners

  1. data identify a previously unappreciated Trim24 (show TRIM24 Proteins)-dependent requirement for IL-1R expression on TH2 cells and an important nonredundant role for T-cell-intrinsic Trim24 (show TRIM24 Proteins) in TH2-mediated allergy and antihelminth immunity

  2. The results present identification of critical regions within the TIR domain of IL-1 (show IL1A Proteins) receptor type in humans and mice.

  3. IL-1R1/MyD88 (show MYD88 Proteins) signaling negatively regulates bone regeneration via impairment of mesenchymal stem cell proliferation, migration and differentiation by inhibiting the Akt (show AKT1 Proteins)/GSK-3beta/beta-catenin (show CTNNB1 Proteins) pathway.

  4. adult mice lacking interleukin-1 receptor 1 (IL-1R1) exhibit increased expression of both the excitatory scaffolding protein postsynaptic density-95 (PSD-95) and inhibitory scaffolding proteingephyrin, respectively, in the hippocampus.

  5. Study provides evidence that IL-1b (show IL1B Proteins) is key regulatory factor for the postictal suppression, and its receptor IL-1R1 may be a potential target for adjuvant treatment of postictal problems

  6. these studies demonstrate, through the use of novel transgenic mice, that IL1R1 (show IL1RN Proteins) on neurons and astrocytes differentially mediates aspects of sleep

  7. Data (including data from studies in knockout mice) suggest that up-regulation of ROS (show ROS1 Proteins)/Nlrp3 (show NLRP3 Proteins)/Il1b (show IL1B Proteins)/Il1r1 (show IL1RN Proteins) (reactive oxygen species/Nlrp3 (show NLRP3 Proteins)/interleukin 1beta/Il1 (show IL1A Proteins) receptor 1) signaling causes severe liver disease during Murine hepatitis virus 3 infection.

  8. Results suggest that the IL-1R1/IL-1ra (show IL1RN Proteins) complex regulates specific ethanol behaviors and affects the sensitivity to flurazepam sedation

  9. IL-1R1 contributes to the IMQ-induced skin inflammation, and disruption of MyD88 (show MYD88 Proteins) signaling completely abrogates this response.

  10. Data show that interleukin 1beta (IL-1beta (show IL1B Proteins)) increased the expression of the IL-1 (show IL1A Proteins) receptor type 1 in hippocampal neuronal cultures.

IL1R1 Protein Profile

Protein Summary

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.

Alternative names and synonyms associated with IL1R1

  • interleukin 1 receptor, type I (IL1R1)
  • interleukin 1 receptor, type I (Il1r1)
  • CD121a protein
  • CD121b protein
  • D2S1473 protein
  • IL-1R-alpha protein
  • IL-iR protein
  • IL1R protein
  • Il1r-1 protein
  • IL1RA protein
  • P80 protein

Protein level used designations for IL1R1

CD121 antigen-like family member A , IL-1R-1 , IL-1RT-1 , IL-1RT1 , antigen CD121a , interleukin 1 receptor alpha, type I , interleukin receptor 1 , interleukin-1 receptor alpha , interleukin-1 receptor type 1 , interleukin-1 receptor type I , IL-1 receptor alpha chain , IL-1R-alpha , p80 , interleukin 1 beta receptor type 1 short transmembrane form , interleukin 1 beta receptor type 1 soluble form , interleukin 1 bete receptor type 1 long transmembrane form

3554 Homo sapiens
16177 Mus musculus
25663 Rattus norvegicus
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