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Since mumps virus SH coimmunoprecipitated with tumor necrosis factor receptor 1 (TNFR1 (show TNFRSF1A Proteins)), RIP1 (show UQCRFS1 Proteins), and IRAK1 (show IRAK1 Proteins), we hypothesize that SH exerts its NF-kappaB (show NFKB1 Proteins) activation inhibitory function by interacting with TNFR1 (show TNFRSF1A Proteins), interleukin-1 receptor type 1 (IL-1R1), and TLR3 (show TLR3 Proteins) complexes in the plasma membrane of infected cells.
ligand-activation of GPER generates a feedforward loop coupling IL1beta induction by CAFs to IL1R1 expression by cancer cells, promoting the up-regulation of IL1beta/IL1R1 target genes such as PTGES, COX2, RAGE and ABCG2
this study shows that IL-1a (show IL1A Proteins) gene variants are not associated with susceptibility to juvenile idiopathic arthritis in Iranian population
The work identifies a pathogenic role of postnatal IL1b (show IL1B Proteins)/IL-1R1 pathway and subsequent prolonged prominent increase of endocannabinoid signaling in adult seizure susceptibility following prolonged febrile seizures, and highlights IL-1R1 as a potential therapeutic target for preventing the development of epilepsy after infantile febrile seizures.
The results present identification of critical regions within the TIR domain of IL-1 (show IL1A Proteins) receptor type in humans and mice.
IL1R1 (show IL1RN Proteins) SNP rs949963 is associated with the susceptibility to asthma in children from Central China and may increase the serum expression of IL1R1 (show IL1RN Proteins).
Altered expression of EP2 (show SPAG11B Proteins) in patients with aspirin-exacerbated respiratory disease contributes to deficient induction of IL-1RI, reducing the capacity of IL-1beta (show IL1B Proteins) to increase COX-2 and mPGES-1 (show PTGES Proteins) expression, which results in low PGE2 production
investigated the association between four inflammatory cytokines (CD121a, interleukin [IL]-1beta, IL-8 (show IL8 Proteins), and IL-11 (show IL11 Proteins)) and coronary heart disease
This study found that the mRNA expression of IL-1R1, TNFR1 (show TNFRSF1A Proteins), and TNFR2 (show TNFRSF1B Proteins) was significantly higher in schizophreina
IL-1R1 expression appears to define a tissue regulatory T cell phenotype together with the expression of CD25 (show IL2RA Proteins), glucocorticoid-induced tumor necrosis factor (show TNF Proteins) receptor family-related gene and CTLA-4 (show CTLA4 Proteins).
Using respective knockout mice it was found that LPS (show TLR4 Proteins)-mediated GIP (show GIP Proteins) secretion was selectively dependent on IL-1 (show IL1A Proteins) signalling.
Results demonstrated the essential role of IL-1R1 in kindling-induced sleep disturbance by using transgenic IL-1R1 KO mice. Epilepsy-induced sleep disturbances were absent in the IL-1R1 KO mice, indicating the importance of IL-1 (show IL1A Proteins) signals. The knockout of IL-1R1 did not change the seizure thresholds, suggesting that IL-1R1 signaling is not in involved in the kindling-induced epileptogenesis.
findings show elements of the IL-1 (show IL1A Proteins) network, including IL-1alpha, IL-1beta (show IL1B Proteins), and IL-1R1, are essential for the optimal host response to VACV cutaneous infection
These data show that the normal distribution of surface glycosylation requires IL-1R, but not MyD88 (show MYD88 Proteins), and is not sufficient to prevent bacterial binding.
IL-1R1 signaling via MyD88 (show MYD88 Proteins) is critical for the first step of inflammatory response to papain.
The work identifies a pathogenic role of postnatal IL1b (show IL1B Proteins)/IL-1R1 pathway and subsequent prolonged prominent increase of endocannabinoid signaling in adult seizure susceptibility following prolonged febrile seizures.
SER140 treatment postpones the onset of diabetes in female NOD mice by interfering with IL-1beta (show IL1B Proteins)/Il1 (show IL1A Proteins) receptor signaling.
IL-1 (show IL1A Proteins) receptor (IL-1R1) deficiency or blockade limits blood pressure elevation in this model by mitigating sodium reabsorption via the NKCC2 (show SLC12A1 Proteins) co-transporter in the nephron.
data identify a previously unappreciated Trim24 (show TRIM24 Proteins)-dependent requirement for IL-1R expression on TH2 cells and an important nonredundant role for T-cell-intrinsic Trim24 (show TRIM24 Proteins) in TH2-mediated allergy and antihelminth immunity
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.
CD121 antigen-like family member A
, antigen CD121a
, interleukin 1 receptor alpha, type I
, interleukin receptor 1
, interleukin-1 receptor alpha
, interleukin-1 receptor type 1
, interleukin-1 receptor type I
, IL-1 receptor alpha chain
, interleukin 1 beta receptor type 1 short transmembrane form
, interleukin 1 beta receptor type 1 soluble form
, interleukin 1 bete receptor type 1 long transmembrane form