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|Antigen||Interleukin 1 Receptor, Type II (IL1R2) Antibodies|
|Conjugate||This IL1R2 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
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Product Details anti-IL1R2 AntibodyTarget Details IL1R2 Application Details Handling Images
|Cross-Reactivity (Details)||Species reactivity (tested):Human.|
|Purification||Protein A Chromatography.|
|Immunogen||Recombinant Human IL-1R type II.|
Target Details IL1R2Product Details anti-IL1R2 Antibody Application Details Handling Images back to top
|Alternative Name||CD121b / IL1R2 (IL1R2 Antibody Abstract)|
|Background||CDw121b is a 65 kD member of the immunoglobulin superfamily also known as IL-1 receptor (IL-1R) type II. The IL-1R family is composed of three proteins: IL-1R type I, IL-1R type II, and the widely expressed IL-1R AcP. Both IL-1R type I and type II bind IL-1 alpha and IL-1 beta, although with differing affinities. The high affinity complex consists of IL-1R type I and IL-1R AcP, whereas IL-1 binds to IL-1R type II with low affinity. The IL-1 receptor antagonist (IL-1RA) can bind to both IL-1R type I and II. IL-1R type II is expressed at low levels on B cells, monocytes/macrophages, neutrophils, basal epithelia of the skin, and T cells. Binding of IL-1 to the high affinity IL-1 receptor mediates thymocyte and T cell activation, fibroblast proliferation, and induction of acute phase protein production. Binding of IL-1 to CDw121b appears to be dispensable for IL-1 signaling and may negatively regulate IL-1 responses acting as a quotdecoy quot receptor.Synonyms: CD121 antigen-like family member B, CDw121b, IL-1R-2, IL-1R-beta, IL1RB, Interleukin-1 receptor type II|
|Research Area||CD Antigens, Surface Receptors of Immune Cells, Cytokines, Immunology, Virology, Inflammation, Cancer, Receptors|
Application DetailsProduct Details anti-IL1R2 Antibody Target Details IL1R2 Handling Images back to top
Immunohistochemistry on Paraffin Sections (10 μg/mL). Western Blot. Immunofluorescence. Immunoprecipitation. ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-IL1R2 Antibody Target Details IL1R2 Application Details Images back to top
|Buffer||0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 with 0.01 % (w/v) Sodium Azide as preserevative.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
ImagesProduct Details anti-IL1R2 Antibody Target Details IL1R2 Application Details Handling back to top