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anti-Human IL1RN Antibodies:
anti-Rat (Rattus) IL1RN Antibodies:
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Human Monoclonal IL1RN Primary Antibody for IA, IHC (fro) - ABIN2191920
Muzio, Polentarutti, Sironi, Poli, De Gioia, Introna, Mantovani, Colotta: Cloning and characterization of a new isoform of the interleukin 1 receptor antagonist. in The Journal of experimental medicine 1995
Show all 2 Pubmed References
Human Polyclonal IL1RN Primary Antibody for FACS, IF - ABIN1882098
Kumar, Kumar, Dixit: Evidences showing association of interleukin-1B polymorphisms with increased risk of gastric cancer in an Indian population. in Biochemical and biophysical research communications 2009
Human Polyclonal IL1RN Primary Antibody for ICC, IF - ABIN442533
Køllgaard, Enevold, Bendtzen, Hansen, Givskov, Holmstrup, Nielsen: Cholesterol crystals enhance TLR2- and TLR4-mediated pro-inflammatory cytokine responses of monocytes to the proatherogenic oral bacterium Porphyromonas gingivalis. in PLoS ONE 2017
associations between the genetic variants and the LPS (show IRF6 Antibodies)-induced IL-6 (show IL6 Antibodies), IL-8 (show IL8 Antibodies), IL-10 (show IL10 Antibodies), IL-1ra and TNF-alpha (show TNF Antibodies) cytokine levels were not significant in the meta-analysis. This present study does not support a strong genetic effect of LPS (show IRF6 Antibodies)-stimulated cytokine production; however, the potential for type II errors should be considered
IL1RA intron 2 VNTR seems to be a genetic marker for overall adiposity status in Malaysian subjects.
Increased IL-1Ra levels in women with polycystic ovary syndrome were largely explained by increasing adiposity. However, serum IL-1Ra concentrations predicted 2-h glucose levels independently of BMI suggesting that increased IL-1Ra may be associated with disturbed glucose metabolism.
demonstrated that IL-1RN VNTR polymorphism might increase the risk of H. pylori infection, especially in Asians
Polymorphisms of Il1rn were not significantly associated with bipolar I disorder in Iranian patients.
Meta-analysis: Serum IL-1RA levels were positively associated with risk of cardiovascular disease. This association may at least partially reflect a response to triggers inducing subclinical inflammation, oxidative stress, and endothelial activation.
Our work highlights the convenience and efficiency of this novel pH-sensitive fluorescent probe and reveals the new biological activity of staurosporine as an agonist for GLUT4 (show SLC2A4 Antibodies) translocation and as an effective insulin (show INS Antibodies) additive analogue.
African American women are at increased risk for early birth, particularly via the inflammatory pathway. Variants of the IL1RN gene, which encode the interleukin-1 receptor antagonist (IL-1Ra) protein, are implicated in early birth
This study reveled that the association of IL1RN haplotype containing RN2 with FIRES, and showed a possible association of IL1RN rs4251981 G > A.
The polymorphism in the combinations IL6 (show IL6 Antibodies) x IL1beta (show IL1B Antibodies) (C and T alleles, respectively), IL1beta (show IL1B Antibodies) (T allele) x IL1RN (*2/*2 genotype), IL6 (show IL6 Antibodies) (C allele) x TNFalpha (show TNF Antibodies) (A allele), IL10 (show IL10 Antibodies) (C/T genotype) x TNFalpha (show TNF Antibodies) (A/A genotype) (P < 0.01, P = 0.01, P < 0.05 and P = 0.03, respectively) were associated with predisposition to developing Dengue and its symptoms
This study identified IL-1Ra as an early immunomodulatory mediator that could be involved in the immunopathogenesis of porcine reproductive and respiratory syndrome virus infections.
The current study is the first to demonstrate ex vivo airway hyperreactivity caused by systemic maternal inflammation and postnatal hyperoxia, and it reveals further preclinical mechanistic insights into IL-1Ra as a treatment targeting key pathophysiological features of Bronchopulmonary dysplasia.
the suppressed early innate/inflammatory responses instigated by the imbalance between IL-1beta (show IL1B Antibodies) and IL-1Ra is an underlying cause for delayed wound healing in the diabetic corneas
we demonstrate that the release of IL1RA in response to genotoxic stress contributes to the immunosuppressive effects of apoptotic cells.
results provide evidence of the key role of IL1RA secreted by MSCs to both control the polarization of macrophages toward a M2 phenotype and inhibit B cell differentiation in vivo.
Allo-transplantation of mesenchymal stem cells reduces Con (show KITLG Antibodies) A liver injury by increasing IL10 (show IL10 Antibodies) production through an IL1Ra dependent macrophage switch.
results demonstrate that small intestinal eosinophils play a pivotal role in the maintenance of intestinal homeostasis by regulating Th17 cells via production of IL-1Ra.
While both contributing to pathogen clearance, NLRP3 (show NLRP3 Antibodies) more than NLRC4 (show NLRC4 Antibodies) contributes to deleterious inflammatory responses in cystic fibrosis (show S100A8 Antibodies) and correlates with defective NLRC4 (show NLRC4 Antibodies)-dependent IL-1Ra production.
IL-1Ra deficiencies might promote early plaque development in 16-week-old apoE (show APOE Antibodies)(-/-) mice.
IL-1Ra is associated with MMP-13 (show MMP13 Antibodies) expression and has a novel function in such regulation without interference of the IL-1 (show IL1A Antibodies) signaling cascade.
These findings demonstrated novel roles for F-spondin (show SPON1 Antibodies) and IL-1Ra in type B CpG oligodeoxynucleotides-mediated cell proliferation and migration of macrophages.
IL-8 (show IL8 Antibodies) and IL-1ra showed correlation with the severity of colitis. These observations should significantly further understandings on the role of neutrophils and monocytes in the immunopathogenesis of ulcerative colitis
Expression of IL-1RN in the endometrium is likely regulated by estradiol and progesterone and suggest that IL-1RN regulates the degree of IL-1 (show IL1A Antibodies) signal transduction and thereby plays an important role in the establishment of equine pregnancy.
The variable number of tandem repeats polymorphism in the IL-1RN gene may be a useful predictor of negative symptom improvement in schizophrenic patients treated with antipsychotic drugs.
common variation across the IL-1RN gene is strongly associated with IL-1RA levels.
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
interleukin 1 receptor antagonist
, IL1 inhibitor
, IL1RN (IL1F3)
, interleukin-1 receptor antagonist protein
, intracellular IL-1 receptor antagonist type II
, intracellular interleukin-1 receptor antagonist (icIL-1ra)
, type II interleukin-1 receptor antagonist
, interleukin-1 receptor antagonist intracellular form
, interleukin-1 receptor antagonist secretory form
, secretory interleukin-1 receptor antagonist