anti-Human IL1RN antibody for Enzyme Immunoassay

Recommended IL1RN Antibody (supplied by: Log in to see )

Antigen
Interleukin 1 Receptor Antagonist (IL1RN) Antibodies
  • IL1RN
  • DIRA
  • ICIL-1RA
  • IL-1RN
  • IL-1ra
  • IL-1ra3
  • IL1F3
  • IL1RA
  • IRAP
  • MVCD4
  • IRAP1
  • F630041P17Rik
  • icIL-1ra
  • IL-1RA
  • interleukin 1 receptor antagonist
  • interleukin 1 receptor, type I
  • IL1RN
  • Il1rn
  • IL1R1
Reactivity
Human
178
33
29
12
9
9
5
5
4
4
4
1
Host
Mouse
148
78
6
5
4
2
Clonality
Monoclonal
Conjugate
This IL1RN antibody is conjugated to Biotin
33
24
6
3
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA)
174
119
63
27
22
22
20
14
14
13
11
11
9
4
3
3
2
2
1
Supplier
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Catalog No. ABIN112013
$ 599.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN5553796 EIA WB Rabbit Middle Region Log in to see Polyclonal
1 ABIN112012 EIA Mouse IgG1 Log in to see 1384-92 3
1 ABIN116864 EIA Func IHC (fro) IHC (p) WB Rabbit Log in to see Polyclonal 4
1 ABIN1107737 EIA IHC (fro) WB Mouse IgG1 Log in to see 2D11 2
1 ABIN264927 EIA IP WB Rabbit IgG Log in to see Polyclonal
1 ABIN264926 EIA Biotin Rabbit IgG Log in to see Polyclonal
1 ABIN1107735 EIA Mouse IgG1 Log in to see KT6
1 ABIN2723391 EIA WB Rabbit IgG Log in to see Polyclonal
1 ABIN2723392 EIA WB Rabbit IgG Log in to see Polyclonal

Top referenced anti-IL1RN antibody for Enzyme Immunoassay

Similar anti-IL1RN Antibodies

Application / Reactivity Human
Blocking Antibody (Inhibition) 1 Antibodies
Dot Blot (DB) 2 Antibodies
ELISA 74 Antibodies
Enzyme Immunoassay (EIA) 10 Antibodies
Flow Cytometry (FACS) 23 Antibodies
Functional Studies (Func) 2 Antibodies
Immunoassay (IA) 3 Antibodies
Immunochromatography (IC) 1 Antibodies
Immunocytochemistry (ICC) 5 Antibodies
Immunofluorescence (IF) 15 Antibodies
Immunofluorescence (fixed cells) (IF/ICC) 5 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 13 Antibodies
Immunohistochemistry (IHC) 35 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 7 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 16 Antibodies
Immunoprecipitation (IP) 8 Antibodies
Neutralization (Neut) 9 Antibodies

General

Antigen Interleukin 1 Receptor Antagonist (IL1RN) Antibodies
Reactivity Human
(178), (33), (29), (12), (9), (9), (5), (5), (4), (4), (4), (1)
Host Mouse
(148), (78), (6), (5), (4), (2)
Clonality (Clone)
Monoclonal   ( )
Conjugate This IL1RN antibody is conjugated to Biotin
(33), (24), (6), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Enzyme Immunoassay (EIA)
(174), (119), (63), (27), (22), (22), (20), (14), (14), (13), (11), (11), (9), (4), (3), (3), (2), (2), (1)
Pubmed 3 references available
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Product Details anti-IL1RN Antibody

Target Details IL1RN Application Details Handling ProductDetails: References for anti-IL1RN antibody (ABIN112013) Images
Purification Affinity Chromatography.
Immunogen Recombinant Human IL-1Ra.
Clone 1384-92
Isotype IgG1

Target Details IL1RN

Product Details anti-IL1RN Antibody Application Details Handling ProductDetails: References for anti-IL1RN antibody (ABIN112013) Images back to top
Antigen
Alternative Name IL1RN / IL1RA (IL1RN Antibody Abstract)
Background The interleukin-1 receptor antagonist (IL-1Ra) is a naturally occurring molecule that shares homology with IL-1alpha and IL-1beta. It binds competitively to IL-1 receptors type I and type II with the same affinity as does IL-1, but does not induce any intracellular response. Two structural variants of IL-1Ra have been described: a 17 kDa form that is secreted from monocytes, macrophages, neutrophils, and other cells (sIL-1Ra) and an 18- kDa form that remains in the cytoplasm of keratinocytes and other epithelial cells, monocytes, and fibroblasts (icIL-1Ra). An additional 16- kDa intracellular isoform of IL-1Ra has been described in neutrophils, monocytes, and hepatic cells. Both of the major isoforms of IL-1Ra are transcribed from the same gene through the use of alternative first exons. The production of IL-1Ra is stimulated by many substances including adherent IgG, other cytokines, and bacterial or viral components. The tissue distribution of IL-1Ra in mice indicates that sIL-1Ra is found predominantly in peripheral blood cells, lung, spleen, and liver, while icIL-1Ra is found in large amounts in skin. Studies in transgenic and knockout mice indicate that IL-1Ra is important in host defence against endotoxin-induced injury. IL-1Ra is produced by hepatic cells with the characteristics of an acute phase protein. Endogenous IL-1Ra is produced in numerous experimental animal models of disease as well as in human autoimmune and chronic inflammatory diseases. The use of neutralizing anti-IL-1Ra antibodies has demonstrated that endogenous IL-1Ra is an important natural antiinflammatory protein in arthritis, colitis, and granulomatous pulmonary disease.Synonyms: ICIL-1RA, IL-1RN, IL-1ra, IL1 inhibitor, IL1F3, IRAP, Interleukin-1 receptor antagonist protein
Gene ID 9606
UniProt P18510
Pathways NF-kappaB Signaling, Hormone Transport

Application Details

Product Details anti-IL1RN Antibody Target Details IL1RN Handling ProductDetails: References for anti-IL1RN antibody (ABIN112013) Images back to top
Application Notes Suitable for ELISA (2 /mL).
Restrictions For Research Use only

Handling

Product Details anti-IL1RN Antibody Target Details IL1RN Application Details ProductDetails: References for anti-IL1RN antibody (ABIN112013) Images back to top
Reconstitution Restore with 0.5 mL distilled water (stock solution).
Concentration 0.4 mg/mL
Buffer Phosphate buffered saline, pH 7.2 containing 0.01 % Thimerosal as a preservative and no stabilizer.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody at -20 °C. Can be shipped at 2-8 °C.

ProductDetails: References for anti-IL1RN antibody (ABIN112013)

Product Details anti-IL1RN Antibody Target Details IL1RN Application Details Handling Images back to top
Background publications

Towbin, Schmitz, van Oostrum, Seitz, Dewald, Zingel, Motz, Vosbeck, Rordorf: "Monoclonal antibody based enzyme-linked and chemiluminescent assays for the human interleukin-1 receptor antagonist. Application to measure hIL-1ra levels in monocyte cultures and synovial fluids." in: Journal of immunological methods, Vol. 170, Issue 1, pp. 125-35, 1994

Dinarello, Wolff: "The role of interleukin-1 in disease." in: The New England journal of medicine, Vol. 328, Issue 2, pp. 106-13, 1993

Dinarello, Thompson: "Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro." in: Immunology today, Vol. 12, Issue 11, pp. 404-10, 1992