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anti-Pig (Porcine) Insulin antibody for Immunohistochemistry (Acetone-fixed)

Recommended Insulin Antibody (supplied by: Log in to see )

Antigen
Insulin (INS) Antibodies
  • AA986540
  • IDDM2
  • ILPR
  • Ins-2
  • ins1
  • ins1-a
  • InsII
  • Insulin
  • IRDN
  • Mody
  • Mody4
  • MODY10
  • proinsulin
  • xins
  • zgc:109842
Reactivity
Pig (Porcine)
563
134
134
97
78
25
4
4
3
3
3
3
2
2
1
1
1
1
1
1
1
Host
Guinea Pig
447
177
56
2
2
Clonality
Polyclonal
Conjugate
This Insulin antibody is un-conjugated
37
28
25
12
10
10
6
5
5
5
5
5
5
5
5
1
1
1
1
Application
Immunohistochemistry (Acetone-fixed) (IHC (af)), ELISA
384
181
140
124
68
56
49
42
39
36
26
13
12
12
9
8
7
6
5
4
4
3
1
1
1
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Catalog No. ABIN2490167
$ 492.86
Plus shipping costs $45.00

Similar anti-Insulin Antibodies

Application / Reactivity Pig (Porcine)
Dot Blot (DB) 2 Antibodies
ELISA 68 Antibodies
ELISA (Capture) 1 Antibodies
Enzyme Immunoassay (EIA) 12 Antibodies
Flow Cytometry (FACS) 17 Antibodies
Functional Studies (Func) 13 Antibodies
Immunoassay (IA) 1 Antibodies
Immunochromatography (IC) 1 Antibodies
Immunocytochemistry (ICC) 19 Antibodies
Immunoelectron Microscopy (IEM) 1 Antibodies
Immunofluorescence (IF) 26 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 1 Antibodies
Immunohistochemistry (IHC) 48 Antibodies
Immunohistochemistry (Acetone-fixed) (IHC (af)) 1 Antibodies
Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp)) 2 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 29 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 56 Antibodies
Immunoprecipitation (IP) 1 Antibodies

General

Antigen Insulin (INS) Antibodies
Reactivity Pig (Porcine)
(563), (134), (134), (97), (78), (25), (4), (4), (3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Host Guinea Pig
(447), (177), (56), (2), (2)
Clonality
Polyclonal
Conjugate This Insulin antibody is un-conjugated
(37), (28), (25), (12), (10), (10), (6), (5), (5), (5), (5), (5), (5), (5), (5), (1), (1), (1), (1)
Application Immunohistochemistry (Acetone-fixed) (IHC (af)), ELISA
(384), (181), (140), (124), (68), (56), (49), (42), (39), (36), (26), (13), (12), (12), (9), (8), (7), (6), (5), (4), (4), (3), (1), (1), (1)
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Product Details anti-Insulin Antibody

Target Details Insulin Application Details Handling Images
Specificity Guinea pig anti Pig insulin antibody recognizes porcine insulin, a hormone secreted by the beta cells of the islets of Langerhans in the pancreas. Insulin belongs to a family of hormones including the insulin-like growth hormones and the relaxins. The insulin precursor is a 108amino acid polypeptide consisting of a 24 aa signal peptide, an insulin A chain, a prohormone polypeptide (also known as the 'C chain') and an insulin B chain together having a predicted molecular mass of 11,672 Da. Active insulin migrates with an apparent molecular mass of 6 kDa in western blotting of porcine, bovine and lapine samples (Schechter et al. 1992).

Insulin is a hormone that functions in carbohydrate homeostasis, and acts to decrease blood glucose concentration by increasing cell permeability to monosaccharides, amino acids and fatty acids, and accelerate glycolysis and glycogen synthesis in the liver, it induces uptake of glucose into cells through its interaction with the glucose transporter GLUT4 (Watson and Pressin 2001). Deficiency of insulin results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumours of B-cell origin such as insulinoma (Schiel et al. 2006).

Guinea pig anti pig insulin antibody has been successfully used to demonstrate the presence og insulin in the islets of Langerhans of murine pancreas using immunohistochemistry on paraffin embedded material (Ortsater et al. 2012).
Cross-Reactivity Pig (Porcine)
Predicted Reactivity Pig
Characteristics GUINEA PIG ANTI PIG INSULIN
Protein size: 108
Immunogen The immunogen for anti-INS antibody: native
Isotype IgG

Target Details Insulin

Product Details anti-Insulin Antibody Application Details Handling Images back to top
Antigen
Alternative Name INS (INS Antibody Abstract)
Gene ID 397458
NCBI Accession NP_001103242
UniProt P01315
Pathways NF-kappaB Signaling, RTK Signaling

Application Details

Product Details anti-Insulin Antibody Target Details Insulin Handling Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-Insulin Antibody Target Details Insulin Application Details Images back to top
Format Liquid
Handling Advice Avoid repeat freeze-thaw cycles.
Storage 4 °C,-20 °C
Storage Comment Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.