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anti-Human Insulin Receptor antibody for Mass Cytometry

Recommended Insulin Receptor Antibody (supplied by: Log in to see )

Antigen
Insulin Receptor (INSR) Antibodies
  • 18402
  • 4932439J01Rik
  • CD220
  • cd220
  • CG18402
  • CTK-1
  • D630014A15Rik
  • DIHR
  • DILR
  • dInR
  • dINR
  • dinr
  • dInr
  • DInR
  • DInr
  • dInsR
  • dir
  • DIR
  • dIR
  • Dir-a
  • Dir-b
  • DIRbeta
  • dIRH
  • DIRH
  • Dmel\\CG18402
  • er10
  • HHF5
  • hhf5
  • Inr
  • INR
  • inr
  • Inr-alpha
  • Inr-beta
  • INS
  • INSR
  • InsR
  • insulin/insulin-like growth factor receptor
  • ir
  • IR
  • IR-A
  • ir-A
  • IR-B
  • l(3)05545
  • l(3)93Dj
  • l(3)er10
  • lnR
  • NV14476
Reactivity
Human
265
81
57
11
8
5
4
2
1
1
1
1
1
1
1
Host
Mouse
219
75
3
Clonality
Monoclonal
Conjugate
This Insulin Receptor antibody is conjugated to PE
21
16
9
8
7
7
1
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Mass Cytometry (CyTOF)
168
122
50
43
35
19
18
12
11
10
9
8
7
7
2
2
1
1
Supplier
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Catalog No. ABIN2662547
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008676689 ABIN2662548 FACS CyTOF PE Mouse IgG2b kappa Log in to see B6-220 3

Top referenced anti-Insulin Receptor antibody for Mass Cytometry

Similar anti-Insulin Receptor Antibodies

Application / Reactivity Human
Blocking Reagent (BR) 4 Antibodies
Dot Blot (DB) 18 Antibodies
ELISA 106 Antibodies
Enzyme Immunoassay (EIA) 7 Antibodies
Flow Cytometry (FACS) 10 Antibodies
Functional Studies (Func) 19 Antibodies
Immunochromatography (IC) 2 Antibodies
Immunocytochemistry (ICC) 8 Antibodies
Immunofluorescence (IF) 9 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 11 Antibodies
Immunohistochemistry (IHC) 36 Antibodies
Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp)) 1 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 6 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 42 Antibodies
Immunoprecipitation (IP) 52 Antibodies
Intracellular Flow Cytometry (ICFC) 2 Antibodies
Mass Cytometry (CyTOF) 2 Antibodies

General

Antigen Insulin Receptor (INSR) Antibodies
Reactivity Human
(265), (81), (57), (11), (8), (5), (4), (2), (1), (1), (1), (1), (1), (1), (1)
Host Mouse
(219), (75), (3)
Clonality (Clone)
Monoclonal   ( )
Conjugate This Insulin Receptor antibody is conjugated to PE
(21), (16), (9), (8), (7), (7), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Flow Cytometry (FACS), Mass Cytometry (CyTOF)
(168), (122), (50), (43), (35), (19), (18), (12), (11), (10), (9), (8), (7), (7), (2), (2), (1), (1)
Pubmed 3 references available
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Product Details anti-Insulin Receptor Antibody

Target Details Insulin Receptor Application Details Handling References for anti-Insulin Receptor Antibody (ABIN2662547) Images
Purification The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
Clone B6-220
Isotype IgG2b kappa

Target Details Insulin Receptor

Product Details anti-Insulin Receptor Antibody Application Details Handling References for anti-Insulin Receptor Antibody (ABIN2662547) Images back to top
Antigen
Alternative Name CD220 (INSR Antibody Abstract)
Background CD220, also known as insulin receptor, is a type I transmembrane receptor tyrosine kinase composed of two extracellular α-subunits and two transmembrane β-subunits. Binding insulin, the insulin receptor forms a heterotetramer of two units to induce autophosphorylation and activation of the tyrosine kinase activity of the receptor. Activation of insulin receptor leads to subsequent downstream signaling in metabolic regulation, inducing glucose uptake, cell growth, differentiation, and apoptosis. Gene mutation in the insulin receptor or decreased insulin receptor signaling leads to insulin-resistant diabetes mellitus and noninsulin-dependent diabetes mellitus (diabetes mellitus type 2). Most normal cells constitutively express insulin receptors. In hematopoietic cells, insulin receptor is constitutively expressed on monocytes and selectively expressed on activated lymphocytes.
Pathways NF-kappaB Signaling, RTK Signaling, AMPK Signaling

Application Details

Product Details anti-Insulin Receptor Antibody Target Details Insulin Receptor Handling References for anti-Insulin Receptor Antibody (ABIN2662547) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-Insulin Receptor Antibody Target Details Insulin Receptor Application Details References for anti-Insulin Receptor Antibody (ABIN2662547) Images back to top
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Protect from prolonged exposure to light. Do not freeze.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-Insulin Receptor Antibody (ABIN2662547)

Product Details anti-Insulin Receptor Antibody Target Details Insulin Receptor Application Details Handling Images back to top
Background publications

Ward, Lawrence: "Ligand-induced activation of the insulin receptor: a multi-step process involving structural changes in both the ligand and the receptor." in: BioEssays : news and reviews in molecular, cellular and developmental biology, Vol. 31, Issue 4, pp. 422-34, 2009

Viardot, Grey, Mackay, Chisholm: "Potential antiinflammatory role of insulin via the preferential polarization of effector T cells toward a T helper 2 phenotype." in: Endocrinology, Vol. 148, Issue 1, pp. 346-53, 2006

Brindle, Tavare, Dickens, Whittaker, Siddle: "Anti-(insulin receptor) monoclonal antibody-stimulated tyrosine phosphorylation in cells transfected with human insulin receptor cDNA." in: The Biochemical journal, Vol. 268, Issue 3, pp. 615-20, 1990

Images

Product Details anti-Insulin Receptor Antibody Target Details Insulin Receptor Application Details Handling References for anti-Insulin Receptor Antibody (ABIN2662547) back to top
Supplier Images
Flow Cytometry (FACS) image for anti-Insulin Receptor antibody (INSR)  (PE) (ABIN2662547) anti-Insulin Receptor (INSR) antibody (PE)