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anti-Human Insulin Receptor antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended Insulin Receptor Antibody (supplied by: Log in to see )

Antigen
Insulin Receptor (INSR) Antibodies
  • 18402
  • 4932439J01Rik
  • CD220
  • cd220
  • CG18402
  • CTK-1
  • D630014A15Rik
  • DIHR
  • DILR
  • dInR
  • dINR
  • dinr
  • dInr
  • DInR
  • DInr
  • dInsR
  • dir
  • DIR
  • dIR
  • Dir-a
  • Dir-b
  • DIRbeta
  • dIRH
  • DIRH
  • Dmel\\CG18402
  • er10
  • HHF5
  • hhf5
  • Inr
  • INR
  • inr
  • Inr-alpha
  • Inr-beta
  • INS
  • INSR
  • InsR
  • insulin/insulin-like growth factor receptor
  • ir
  • IR
  • IR-A
  • ir-A
  • IR-B
  • l(3)05545
  • l(3)93Dj
  • l(3)er10
  • lnR
  • NV14476
Reactivity
Human, Mouse (Murine), Rat (Rattus)
265
80
56
11
8
5
4
2
1
1
1
1
1
1
1
Host
Rabbit
218
76
3
Clonality
Polyclonal
Conjugate
This Insulin Receptor antibody is un-conjugated
21
16
9
9
7
7
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
167
122
50
42
35
19
18
12
10
10
10
8
7
7
2
2
2
1
Supplier
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Catalog No. ABIN671841
$ 269.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008846439 ABIN2814856 IF (p) Alexa Fluor 594 Rabbit IgG AA 50-100 Log in to see Polyclonal
0.0008846439 ABIN902850 IF (p) Alexa Fluor 488 Rabbit IgG Log in to see Polyclonal
0.0008846439 ABIN902851 IF (p) Alexa Fluor 555 Rabbit IgG Log in to see Polyclonal
0.0008846439 ABIN902852 IF (p) Alexa Fluor 647 Rabbit IgG Log in to see Polyclonal
0.0008846439 ABIN902849 IF (p) Alexa Fluor 350 Rabbit IgG Log in to see Polyclonal
0.0008846439 ABIN671847 IF (p) Cy7 Rabbit IgG Log in to see Polyclonal
0.0008846439 ABIN671845 IF (p) Cy5 Rabbit IgG Log in to see Polyclonal
0.0008846439 ABIN671844 IF (p) Cy3 Rabbit IgG Log in to see Polyclonal
0.0008846439 ABIN671846 IF (p) Cy5.5 Rabbit IgG Log in to see Polyclonal
0.0008846439 ABIN671848 IF (p) FITC Rabbit IgG Log in to see Polyclonal

Similar anti-Insulin Receptor Antibodies

Application / Reactivity Rat (Rattus) Mouse (Murine)
Blocking Reagent (BR) 1 Antibodies
ELISA 18 Antibodies 31 Antibodies
Enzyme Immunoassay (EIA) 2 Antibodies 3 Antibodies
Immunocytochemistry (ICC) 1 Antibodies 3 Antibodies
Immunofluorescence (IF) 6 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 11 Antibodies
Immunohistochemistry (IHC) 5 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 2 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 5 Antibodies
Immunoprecipitation (IP) 9 Antibodies
Neutralization (Neut) 1 Antibodies
Western Blotting (WB) 44 Antibodies
Immunochromatography (IC) 2 Antibodies

General

Antigen Insulin Receptor (INSR) Antibodies
Reactivity Human, Mouse (Murine), Rat (Rattus)
(265), (80), (56), (11), (8), (5), (4), (2), (1), (1), (1), (1), (1), (1), (1)
Host Rabbit
(218), (76), (3)
Clonality
Polyclonal
Conjugate This Insulin Receptor antibody is un-conjugated
(21), (16), (9), (9), (7), (7), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(167), (122), (50), (42), (35), (19), (18), (12), (10), (10), (10), (8), (7), (7), (2), (2), (2), (1)
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Product Details anti-Insulin Receptor Antibody

Target Details Insulin Receptor Application Details Handling Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human Insulin Receptor
Isotype IgG

Target Details Insulin Receptor

Product Details anti-Insulin Receptor Antibody Application Details Handling Images back to top
Antigen
Alternative Name Insulin Receptor (INSR Antibody Abstract)
Background

Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosines residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD, regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway.

Subcellular location: Extracellular


Synonyms: HHF5, CD220, Insulin receptor, IR, INSR
Gene ID 3643
UniProt P06213
Research Area Cardiovascular, Atherosclerosis, Tyrosine Kinases, Hormones, Diabetes, Receptors
Pathways NF-kappaB Signaling, RTK Signaling, AMPK Signaling

Application Details

Product Details anti-Insulin Receptor Antibody Target Details Insulin Receptor Handling Images back to top
Application Notes WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
Restrictions For Research Use only

Handling

Product Details anti-Insulin Receptor Antibody Target Details Insulin Receptor Application Details Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

Images

Product Details anti-Insulin Receptor Antibody Target Details Insulin Receptor Application Details Handling back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-Insulin Receptor antibody (INSR) (ABIN671841) Formalin-fixed and paraffin embedded rat liver tissue labeled Anti-Insulin Receptor/C...