anti-Mouse (Murine) Insulin Receptor antibody for Immunohistochemistry

Recommended Insulin Receptor Antibody (supplied by: Log in to see )

Antigen
Insulin Receptor (INSR) Antibodies
  • 18402
  • CG18402
  • DIHR
  • DILR
  • DIR
  • DIRH
  • DIRbeta
  • DInR
  • DInr
  • Dir-a
  • Dir-b
  • Dmel\\CG18402
  • INR
  • INS
  • IR
  • Inr
  • Inr-alpha
  • Inr-beta
  • InsR
  • dINR
  • dIR
  • dIRH
  • dInR
  • dInr
  • dInsR
  • dinr
  • dir
  • er10
  • inr
  • insulin/insulin-like growth factor receptor
  • l(3)05545
  • l(3)93Dj
  • l(3)er10
  • lnR
  • INSR
  • NV14476
  • CD220
  • HHF5
  • 4932439J01Rik
  • D630014A15Rik
  • IR-A
  • IR-B
  • ir-A
  • ir
  • cd220
  • hhf5
  • CTK-1
  • Insulin-like receptor
  • insulin receptor
  • insulin receptor precursor
  • InR
  • INSR
  • Insr
  • insr
  • DAF-2
Epitope
Middle Region
39
33
21
17
17
14
12
9
9
7
7
6
6
5
5
5
5
5
5
4
4
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Dog (Canine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Rat (Rattus), Zebrafish
315
130
94
23
22
21
20
17
17
8
5
4
2
1
1
1
1
1
Host
Rabbit
252
88
8
1
1
Clonality
Polyclonal
Conjugate
This Insulin Receptor antibody is un-conjugated
26
18
12
11
9
9
4
3
3
3
3
3
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
214
144
72
57
46
32
17
16
13
12
9
8
7
7
3
2
2
2
Options
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Catalog No. ABIN2792204
$ 289.00
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
9.77208 ABIN926933 IHC WB Rabbit Middle Region Log in to see Polyclonal
1 ABIN2776774 IHC WB Rabbit Middle Region Log in to see Polyclonal 1
1 ABIN3182542 ELISA IHC WB Rabbit IgG pTyr1361 Log in to see Polyclonal
1 ABIN3182317 ELISA IHC WB Rabbit IgG pThr1375 Log in to see Polyclonal
1 ABIN3198163 IHC WB Rabbit C-Term, pTyr1355 Log in to see Polyclonal
1 ABIN3198164 IC IF IHC WB Rabbit C-Term, pTyr1361 Log in to see Polyclonal
1 ABIN1859479 ICC IHC IP WB Rabbit IgG AA 1101-1372 Log in to see Polyclonal
1 ABIN3185195 ELISA IHC WB Rabbit IgG Ser58 Log in to see Polyclonal
1 ABIN2755564 IC IF IHC WB Rabbit C-Term Log in to see Polyclonal
1 ABIN601626 IHC WB Rabbit IgG N-Term Log in to see Polyclonal
1 ABIN1584616 IP IHC ELISA WB Rabbit N-Term Log in to see Polyclonal
1 ABIN2878497 IHC WB Rabbit IgG Log in to see Polyclonal
1 ABIN2886769 IHC WB Rabbit pTyr1355 Log in to see Polyclonal
1 ABIN2972579 IF/ICC IHC WB Rabbit C-Term, pTyr1361 Log in to see Polyclonal
1 ABIN2750326 ELISA IHC IP WB FITC Rabbit IgG AA 950-1000, C-Term Log in to see Polyclonal
1 ABIN2750324 ELISA IHC IP WB Rabbit IgG AA 950-1000, C-Term Log in to see Polyclonal
1 ABIN3066099 IF/ICC IHC WB Rabbit C-Term Log in to see Polyclonal
1 ABIN2934936 ELISA IF/ICC IHC WB Rabbit AA 1101-1372 Log in to see Polyclonal
1 ABIN5557676 ELISA IHC IP WB Biotin Rabbit C-Term Log in to see Polyclonal

Similar anti-Insulin Receptor Antibodies

Application / Reactivity Dog (Canine) Human Mouse (Murine) Rat (Rattus) Zebrafish Guinea Pig Horse (Equine)
Immunofluorescence (fixed cells) (IF/ICC) 1 Antibodies 6 Antibodies 3 Antibodies 1 Antibodies
Western Blotting (WB) 19 Antibodies 181 Antibodies 109 Antibodies 79 Antibodies 3 Antibodies 5 Antibodies 8 Antibodies
Neutralization (Neut) 7 Antibodies
Mass Cytometry (CyTOF) 2 Antibodies
Intracellular Flow Cytometry (ICFC) 2 Antibodies
Immunoprecipitation (IP) 53 Antibodies 17 Antibodies 18 Antibodies 6 Antibodies

General

Antigen Insulin Receptor (INSR) Antibodies
Epitope Middle Region
(39), (33), (21), (17), (17), (14), (12), (9), (9), (7), (7), (6), (6), (5), (5), (5), (5), (5), (5), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Dog (Canine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Rat (Rattus), Zebrafish
(315), (130), (94), (23), (22), (21), (20), (17), (17), (8), (5), (4), (2), (1), (1), (1), (1), (1)
Host Rabbit
(252), (88), (8), (1), (1)
Clonality
Polyclonal
Conjugate This Insulin Receptor antibody is un-conjugated
(26), (18), (12), (11), (9), (9), (4), (3), (3), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunohistochemistry (IHC), Western Blotting (WB)
(214), (144), (72), (57), (46), (32), (17), (16), (13), (12), (9), (8), (7), (7), (3), (2), (2), (2)
Pubmed 1 reference available
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Product Details anti-Insulin Receptor Antibody

Target Details Insulin Receptor Application Details Handling ProductDetails: References for anti-Insulin Receptor antibody (ABIN2792204) Images
Sequence SSHCQREEAG GRDGGSSLGF KRSYEEHIPY THMNGGKKNG RILTLPRSNP
Predicted Reactivity Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 93%, Rat: 93%, Zebrafish: 86%
Characteristics This is a rabbit polyclonal antibody against INSR. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Immunogen The immunogen is a synthetic peptide directed towards the middle region of human INSR

Target Details Insulin Receptor

Product Details anti-Insulin Receptor Antibody Application Details Handling ProductDetails: References for anti-Insulin Receptor antibody (ABIN2792204) Images back to top
Antigen
Alternative Name INSR (INSR Antibody Abstract)
Background This receptor binds insulin and has a tyrosine-protein kinase activity. Isoform Short has a higher affinity for insulin. INSR mediates the metabolic functions of insulin. INSR binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K). INSR can activate PI3K either directly by binding to the p85 regulatory subunit, or indirectly via IRS1. When present in a hybrid receptor with IGF1R, it binds IGF1.A report shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, another report shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: CD220, HHF5
Protein Interaction Partner: KRT31, UBC, ARRB2, MOK, Grb2, Hgf, DOK1, SH2B1, Stat5b, TEAD1, STAT5A, JAK2, JAK1, IRS1, IRF7, PLCG1, GRB10, Socs6, Socs1, SOCS3, SH2B2, HGS, INPPL1, Calmodulin, Mad2l1, KRT27, DOK5, DOK4, SNX6, SNX4, SNX2, ACP1, PTPN2, SYNCRIP, FRS2, PIK3R3, VAV3, ARHGAP
Protein Size: 1382
Molecular Weight 154 kDa
Gene ID 3643
NCBI Accession NM_000208, NP_000199
UniProt P06213
Pathways NF-kappaB Signaling, RTK Signaling, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity

Application Details

Product Details anti-Insulin Receptor Antibody Target Details Insulin Receptor Handling ProductDetails: References for anti-Insulin Receptor antibody (ABIN2792204) Images back to top
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 1382 AA

Restrictions For Research Use only

Handling

Product Details anti-Insulin Receptor Antibody Target Details Insulin Receptor Application Details ProductDetails: References for anti-Insulin Receptor antibody (ABIN2792204) Images back to top
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

ProductDetails: References for anti-Insulin Receptor antibody (ABIN2792204)

Product Details anti-Insulin Receptor Antibody Target Details Insulin Receptor Application Details Handling Images back to top
Background publications

Netzer, Freudenberg, Heinze, Heinze-Kuhn, Goebel, McCarthy, Roses, Göbel, Todt, Kubisch: "Replication study of the insulin receptor gene in migraine with aura." in: Genomics, Vol. 91, Issue 6, pp. 503-7, 2008

Images

Product Details anti-Insulin Receptor Antibody Target Details Insulin Receptor Application Details Handling ProductDetails: References for anti-Insulin Receptor antibody (ABIN2792204) back to top
Supplier Images
Western Blotting (WB) image for anti-Insulin Receptor antibody (INSR) (Middle Region) (ABIN2792204) WB Suggested Anti-INSR Antibody Titration: 0.2-1 ug/ml
ELISA Titer: ...
Immunohistochemistry (IHC) image for anti-Insulin Receptor antibody (INSR) (Middle Region) (ABIN2792204) anti-Insulin Receptor (INSR) (Middle Region) antibody (Image 2)
Western Blotting (WB) image for anti-Insulin Receptor antibody (INSR) (Middle Region) (ABIN2792204) WB Suggested Anti-INSR
Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500 <...