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Data indicate the complexity of interactions between Pin1 (show PIN1 ELISA Kits) and activated IRAK1, suggesting that phosphorylation of neighboring Ser (show SIGLEC1 ELISA Kits)/Thr (show TRH ELISA Kits)-Pro motifs in proteins might provide competitive advantage at cellular concentrations for engaging with Pin1 (show PIN1 ELISA Kits).
IRAK1 is a direct target of miR (show MLXIP ELISA Kits)-146b and has functional roles to inhibit various aggressive papillary thyroid carcinoma cell activities.
our data strongly suggest that AQCA-mediated suppression of inflammatory responses could be managed by a direct interference of signaling cascades including IRAK and Syk (show SYK ELISA Kits), linked to the activation of NF-kappaB (show NFKB1 ELISA Kits) and AP-1 (show FOSB ELISA Kits).
The IRAK1 rs3027898 was not associated with RA, whereas C allele of miR (show MLXIP ELISA Kits)-146a rs2910164 was found to be protective.
the Xq28 region containing TMEM187 (show TMEM187 ELISA Kits) and IRAK1 (rs13397, rs1059703, and rs1059702) with rheumatoid arthritis (RA)susceptibility; results replicated association of the 3 Xq28 polymorphisms with RA risk in Tunisian and French populations and suggested that RA susceptibility is associated with TMEM187 (show TMEM187 ELISA Kits)-IRAK1 polymorphisms in women
IRAK1 expression was not significantly increased in tympanic membrane of otitis media patients.
Our findings reveal that IRAK1 promotes cell survival and is an attractive therapeutic target in head and neck squamous cell carcinomas
miR146a has an important promoting effect on the apoptosis of granulosa cells by targeting IRAK1 and TRAF6 (show TRAF6 ELISA Kits) via the caspase (show CASP3 ELISA Kits) cascade pathway
This is the first study to show an association between single nucleotide polymorphisms in IRAK1, IRAK4 (show IRAK4 ELISA Kits) and MyD88 (show MYD88 ELISA Kits), and the presence of severe invasive pneumococcal disease.
This meta-analysis suggests that the miR (show MLXIP ELISA Kits)-499 rs374644 and IRAKI rs3027898 polymorphisms are associated with susceptibility to inflammatory arthritis. [review]
Torreya nucifera butanol fraction exhibits anti-inflammatory activities by direct inhibition of macrophage Src (show SRC ELISA Kits)/Syk (show SYK ELISA Kits)/NF-kappaB (show NFKB1 ELISA Kits) and IRAK1/AP-1 (show JUN ELISA Kits) signaling.
IRAK1 is involved in TLR4 (show TLR4 ELISA Kits)-mediated downregulation of ABCA1 (show ABCA1 ELISA Kits) expression and lipid accumulation in VSMCs.
plays an important role in intestinal inflammation by mediating T cell activation, differentiation, and accumulation in the gut (show GUSB ELISA Kits)
Mangiferin ameliorates colitis by inhibiting IRAK1 phosphorylation in NF-kappaB (show NFKB1 ELISA Kits) and MAPK (show MAPK1 ELISA Kits) pathways
miR (show MLXIP ELISA Kits)-146a ameliorates liver ischemia/reperfusion injury in vivo and hypoxia/reoxygenation injury in vitro by directly suppressing IRAK1 and TRAF6 (show TRAF6 ELISA Kits).
miR (show MLXIP ELISA Kits)-146a attenuates sepsis-induced cardiac dysfunction by preventing NF-kappaB (show NFKB1 ELISA Kits) activation, inflammatory cell infiltration, and inflammatory cytokine production via targeting of IRAK and TRAF6 (show TRAF6 ELISA Kits) in both cardiomyocytes and inflammatory monocytic cells.
IRAK1 deficiency impacts multiple TLR-dependent pathways and decreases early cytokine responses following polymicrobial sepsis.
CD40 (show CD40 ELISA Kits) signaling induces IRAK1 sumoylation in the presence of TNF receptor-associated factor 2 (TRAF2 (show TRAF2 ELISA Kits)) and intracellular isoform of osteopontin (show SPP1 ELISA Kits)
Mosaicism for IRAK1 expression is accompanied by skewing toward deficient immune cell populations, producing a phenotype that is preconditioned for improved sepsis outcome
IRAK-1 bypasses priming and directly links Toll (show TLR4 ELISA Kits)-like receptors to rapid NLRP3 (show NLRP3 ELISA Kits) inflammasome activation.
Results describe a new full-length gene model for the bovine IRAK1 gene.
ALOX5AP (show ALOX5AP ELISA Kits), CPNE3 (show CPNE3 ELISA Kits), IL1R2 (show IL1R2 ELISA Kits), IL6 (show IL6 ELISA Kits), TLR2 (show TLR2 ELISA Kits), TLR4 (show TLR4 ELISA Kits), and THY1 (show THY1 ELISA Kits) were upregulated in blood polymorphonuclear cells in negative energy balance versus positive energy balance cows.
This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
interleukin-1 receptor-associated kinase 1
, Pelle homolog
, interleukin-1 receptor-associated kinase-1
, pelle-like protein kinase
, interleukin receptor associated kinase 1