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Our findings reveal that IRAK1 promotes cell survival and is an attractive therapeutic target in head and neck squamous cell carcinomas
miR146a has an important promoting effect on the apoptosis of granulosa cells by targeting IRAK1 and TRAF6 (show TRAF6 Proteins) via the caspase (show CASP3 Proteins) cascade pathway
This is the first study to show an association between single nucleotide polymorphisms in IRAK1, IRAK4 (show IRAK4 Proteins) and MyD88 (show MYD88 Proteins), and the presence of severe invasive pneumococcal disease.
This meta-analysis suggests that the miR (show MLXIP Proteins)-499 rs374644 and IRAKI rs3027898 polymorphisms are associated with susceptibility to inflammatory arthritis. [review]
IRAK1 overexpression drive aggressive growth, metastasis and acquired resistance to paclitaxel treatment in breast cancer.
Data suggest that TLR2 (toll like receptor 2) is down-regulated by microRNA-UL112-3p from human Cytomegalovirus; microRNA-UL112-3p also down-regulates TLR2-induced post-translational activation of IRAK1 signaling.
These data demonstrated that these three single nucleotide polymorphisms (rs3027898, rs1059702, rs1059703) in IRAK1 were associated with autoimmune diseases risk.
Src (show SRC Proteins), Syk (show SYK Proteins), IRAK1, and IRAK4 (show IRAK4 Proteins) have roles in anti-inflammatory responses mediated by dietary flavonoid Kaempferol
High mRNA levels of IRAK1 and IRAK4 (show IRAK4 Proteins) correlated with VKH disease activity.
expression of IRAK1 in lung cancer was significantly higher compared with that in normal lung tissues and was correlated with TNM (show ODZ1 Proteins) stage, lymphatic metastasis and tumor size.
IRAK1 is involved in TLR4 (show TLR4 Proteins)-mediated downregulation of ABCA1 (show ABCA1 Proteins) expression and lipid accumulation in VSMCs.
plays an important role in intestinal inflammation by mediating T cell activation, differentiation, and accumulation in the gut (show GUSB Proteins)
Mangiferin ameliorates colitis by inhibiting IRAK1 phosphorylation in NF-kappaB (show NFKB1 Proteins) and MAPK (show MAPK1 Proteins) pathways
miR (show MLXIP Proteins)-146a ameliorates liver ischemia/reperfusion injury in vivo and hypoxia/reoxygenation injury in vitro by directly suppressing IRAK1 and TRAF6 (show TRAF6 Proteins).
miR (show MLXIP Proteins)-146a attenuates sepsis-induced cardiac dysfunction by preventing NF-kappaB (show NFKB1 Proteins) activation, inflammatory cell infiltration, and inflammatory cytokine production via targeting of IRAK and TRAF6 (show TRAF6 Proteins) in both cardiomyocytes and inflammatory monocytic cells.
IRAK1 deficiency impacts multiple TLR-dependent pathways and decreases early cytokine responses following polymicrobial sepsis.
CD40 (show CD40 Proteins) signaling induces IRAK1 sumoylation in the presence of TNF receptor-associated factor 2 (TRAF2 (show TRAF2 Proteins)) and intracellular isoform of osteopontin (show SPP1 Proteins)
Mosaicism for IRAK1 expression is accompanied by skewing toward deficient immune cell populations, producing a phenotype that is preconditioned for improved sepsis outcome
IRAK-1 bypasses priming and directly links Toll (show TLR4 Proteins)-like receptors to rapid NLRP3 (show NLRP3 Proteins) inflammasome activation.
Data indicate that IRAK1 is required for LMP1 (show PDLIM7 Proteins)-induced CaMKII (show CAMK2G Proteins) activation and p65/RelA (show NFkBP65 Proteins) serine 536 phosphorylation.
Results describe a new full-length gene model for the bovine IRAK1 gene.
ALOX5AP (show ALOX5AP Proteins), CPNE3 (show CPNE3 Proteins), IL1R2 (show IL1R2 Proteins), IL6 (show IL6 Proteins), TLR2, TLR4 (show TLR4 Proteins), and THY1 (show THY1 Proteins) were upregulated in blood polymorphonuclear cells in negative energy balance versus positive energy balance cows.
This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
interleukin-1 receptor-associated kinase 1
, Pelle homolog
, interleukin-1 receptor-associated kinase-1
, pelle-like protein kinase
, interleukin receptor associated kinase 1