Browse our IRAK1 Proteins (IRAK1)

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Interleukin-1 Receptor-Associated Kinase 1 Proteins (IRAK1)
On are 9 Interleukin-1 Receptor-Associated Kinase 1 (IRAK1) Proteins from 7 different suppliers available. Additionally we are shipping IRAK1 Antibodies (274) and IRAK1 Kits (28) and many more products for this protein. A total of 324 IRAK1 products are currently listed.
AA408924, Il1rak, IRAK, IRAK-1, IRAK1, IRAK1-S, mPLK, pelle, Plpk, RGD1563841
list all proteins Gene Name GeneID UniProt
IRAK1 3654 P51617
IRAK1 16179 Q62406
Rat IRAK1 IRAK1 363520  

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IRAK1 Proteins (IRAK1) by Origin

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Human Interleukin-1 Receptor-Associated Kinase 1 (IRAK1) interaction partners

  1. High IRAK1 expression is associated with multiple myeloma.

  2. TLR4 (show TLR4 Proteins)- and TLR2-induced IRAK-ERK (show EPHB2 Proteins) pathway cross-talks with p67phox (show NCF2 Proteins)-Nox-2 (show CYBB Proteins) for reactive oxygen species generation, thus regulating IL-1beta (show IL1B Proteins) transcription and processing in monocytic cells.

  3. Data suggest that, in monocytes and macrophages, the interleukin-1B- (IL1B (show IL1B Proteins))-stimulated trans-autophosphorylation of IRAK4 (interleukin-1 receptor-associated kinase 4 (show IRAK4 Proteins)) is initiated by MYD88- (myeloid differentiation primary response gene 88 (show MYD88 Proteins))-induced dimerization of IRAK4 (show IRAK4 Proteins). In contrast, IRAK1 is inactive in unstimulated monocytes/macrophages and is converted to an active protein kinase (show CDK7 Proteins) in response to IL1B (show IL1B Proteins).

  4. Data indicate the complexity of interactions between Pin1 (show PIN1 Proteins) and activated IRAK1, suggesting that phosphorylation of neighboring Ser (show SIGLEC1 Proteins)/Thr (show TRH Proteins)-Pro motifs in proteins might provide competitive advantage at cellular concentrations for engaging with Pin1 (show PIN1 Proteins).

  5. IRAK1 is a direct target of miR (show MLXIP Proteins)-146b and has functional roles to inhibit various aggressive papillary thyroid carcinoma cell activities.

  6. our data strongly suggest that AQCA-mediated suppression of inflammatory responses could be managed by a direct interference of signaling cascades including IRAK and Syk (show SYK Proteins), linked to the activation of NF-kappaB (show NFKB1 Proteins) and AP-1 (show FOSB Proteins).

  7. The IRAK1 rs3027898 was not associated with RA, whereas C allele of miR (show MLXIP Proteins)-146a rs2910164 was found to be protective.

  8. the Xq28 region containing TMEM187 and IRAK1 (rs13397, rs1059703, and rs1059702) with rheumatoid arthritis (RA)susceptibility; results replicated association of the 3 Xq28 polymorphisms with RA risk in Tunisian and French populations and suggested that RA susceptibility is associated with TMEM187-IRAK1 polymorphisms in women

  9. IRAK1 expression was not significantly increased in tympanic membrane of otitis media patients.

  10. Our findings reveal that IRAK1 promotes cell survival and is an attractive therapeutic target in head and neck squamous cell carcinomas

Mouse (Murine) Interleukin-1 Receptor-Associated Kinase 1 (IRAK1) interaction partners

  1. Data, including data from studies in knockout mice, suggest that Irak1 is involved in regulating glucose metabolism and insulin (show INS Proteins) sensitivity in skeletal muscle (but not in liver and not in obesity due to high-fat diet); insulin (show INS Proteins) sensitivity is 30% higher in Irak1 knockout mice on chow diet, but Irak1 deletion does not affect development of glucose intolerance due to high-fat diet.

  2. Suppression of IRAK1 or IRAK4 (show IRAK4 Proteins) Catalytic Activity, but Not Type 1 IFN Signaling, Prevents Lupus Nephritis in Mice Expressing a Ubiquitin Binding-Defective Mutant of ABIN1 (show TNIP1 Proteins)

  3. Torreya nucifera butanol fraction exhibits anti-inflammatory activities by direct inhibition of macrophage Src (show SRC Proteins)/Syk (show SYK Proteins)/NF-kappaB (show NFKB1 Proteins) and IRAK1/AP-1 (show JUN Proteins) signaling.

  4. IRAK1 is involved in TLR4 (show TLR4 Proteins)-mediated downregulation of ABCA1 (show ABCA1 Proteins) expression and lipid accumulation in VSMCs.

  5. plays an important role in intestinal inflammation by mediating T cell activation, differentiation, and accumulation in the gut (show GUSB Proteins)

  6. Mangiferin ameliorates colitis by inhibiting IRAK1 phosphorylation in NF-kappaB (show NFKB1 Proteins) and MAPK (show MAPK1 Proteins) pathways

  7. miR (show MLXIP Proteins)-146a ameliorates liver ischemia/reperfusion injury in vivo and hypoxia/reoxygenation injury in vitro by directly suppressing IRAK1 and TRAF6 (show TRAF6 Proteins).

  8. miR (show MLXIP Proteins)-146a attenuates sepsis-induced cardiac dysfunction by preventing NF-kappaB (show NFKB1 Proteins) activation, inflammatory cell infiltration, and inflammatory cytokine production via targeting of IRAK and TRAF6 (show TRAF6 Proteins) in both cardiomyocytes and inflammatory monocytic cells.

  9. IRAK1 deficiency impacts multiple TLR-dependent pathways and decreases early cytokine responses following polymicrobial sepsis.

  10. CD40 (show CD40 Proteins) signaling induces IRAK1 sumoylation in the presence of TNF receptor-associated factor 2 (TRAF2 (show TRAF2 Proteins)) and intracellular isoform of osteopontin (show SPP1 Proteins)

Cow (Bovine) Interleukin-1 Receptor-Associated Kinase 1 (IRAK1) interaction partners

  1. Results describe a new full-length gene model for the bovine IRAK1 gene.

  2. ALOX5AP (show ALOX5AP Proteins), CPNE3 (show CPNE3 Proteins), IL1R2 (show IL1R2 Proteins), IL6 (show IL6 Proteins), TLR2, TLR4 (show TLR4 Proteins), and THY1 (show THY1 Proteins) were upregulated in blood polymorphonuclear cells in negative energy balance versus positive energy balance cows.

IRAK1 Protein Profile

Protein Summary

This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with IRAK1

  • interleukin-1 receptor-associated kinase 1 (IRAK1)
  • interleukin-1 receptor-associated kinase 1 (irak1)
  • interleukin-1 receptor-associated kinase 1 (Irak1)
  • AA408924 protein
  • Il1rak protein
  • IRAK protein
  • IRAK-1 protein
  • IRAK1 protein
  • IRAK1-S protein
  • mPLK protein
  • pelle protein
  • Plpk protein
  • RGD1563841 protein

Protein level used designations for IRAK1

interleukin-1 receptor-associated kinase 1 , IRAK-1 , Pelle homolog , interleukin-1 receptor-associated kinase-1 , pelle-like protein kinase , interleukin receptor associated kinase 1

465935 Pan troglodytes
569226 Danio rerio
3654 Homo sapiens
16179 Mus musculus
363520 Rattus norvegicus
492247 Canis lupus familiaris
396606 Sus scrofa
533953 Bos taurus
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