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Data indicate the complexity of interactions between Pin1 (show PIN1 Proteins) and activated IRAK1, suggesting that phosphorylation of neighboring Ser (show SIGLEC1 Proteins)/Thr (show TRH Proteins)-Pro motifs in proteins might provide competitive advantage at cellular concentrations for engaging with Pin1 (show PIN1 Proteins).
IRAK1 is a direct target of miR (show MLXIP Proteins)-146b and has functional roles to inhibit various aggressive papillary thyroid carcinoma cell activities.
our data strongly suggest that AQCA-mediated suppression of inflammatory responses could be managed by a direct interference of signaling cascades including IRAK and Syk (show SYK Proteins), linked to the activation of NF-kappaB (show NFKB1 Proteins) and AP-1 (show FOSB Proteins).
The IRAK1 rs3027898 was not associated with RA, whereas C allele of miR (show MLXIP Proteins)-146a rs2910164 was found to be protective.
the Xq28 region containing TMEM187 and IRAK1 (rs13397, rs1059703, and rs1059702) with rheumatoid arthritis (RA)susceptibility; results replicated association of the 3 Xq28 polymorphisms with RA risk in Tunisian and French populations and suggested that RA susceptibility is associated with TMEM187-IRAK1 polymorphisms in women
IRAK1 expression was not significantly increased in tympanic membrane of otitis media patients.
Our findings reveal that IRAK1 promotes cell survival and is an attractive therapeutic target in head and neck squamous cell carcinomas
miR146a has an important promoting effect on the apoptosis of granulosa cells by targeting IRAK1 and TRAF6 (show TRAF6 Proteins) via the caspase (show CASP3 Proteins) cascade pathway
This is the first study to show an association between single nucleotide polymorphisms in IRAK1, IRAK4 (show IRAK4 Proteins) and MyD88 (show MYD88 Proteins), and the presence of severe invasive pneumococcal disease.
This meta-analysis suggests that the miR (show MLXIP Proteins)-499 rs374644 and IRAKI rs3027898 polymorphisms are associated with susceptibility to inflammatory arthritis. [review]
Torreya nucifera butanol fraction exhibits anti-inflammatory activities by direct inhibition of macrophage Src (show SRC Proteins)/Syk (show SYK Proteins)/NF-kappaB (show NFKB1 Proteins) and IRAK1/AP-1 (show JUN Proteins) signaling.
IRAK1 is involved in TLR4 (show TLR4 Proteins)-mediated downregulation of ABCA1 (show ABCA1 Proteins) expression and lipid accumulation in VSMCs.
plays an important role in intestinal inflammation by mediating T cell activation, differentiation, and accumulation in the gut (show GUSB Proteins)
Mangiferin ameliorates colitis by inhibiting IRAK1 phosphorylation in NF-kappaB (show NFKB1 Proteins) and MAPK (show MAPK1 Proteins) pathways
miR (show MLXIP Proteins)-146a ameliorates liver ischemia/reperfusion injury in vivo and hypoxia/reoxygenation injury in vitro by directly suppressing IRAK1 and TRAF6 (show TRAF6 Proteins).
miR (show MLXIP Proteins)-146a attenuates sepsis-induced cardiac dysfunction by preventing NF-kappaB (show NFKB1 Proteins) activation, inflammatory cell infiltration, and inflammatory cytokine production via targeting of IRAK and TRAF6 (show TRAF6 Proteins) in both cardiomyocytes and inflammatory monocytic cells.
IRAK1 deficiency impacts multiple TLR-dependent pathways and decreases early cytokine responses following polymicrobial sepsis.
CD40 (show CD40 Proteins) signaling induces IRAK1 sumoylation in the presence of TNF receptor-associated factor 2 (TRAF2 (show TRAF2 Proteins)) and intracellular isoform of osteopontin (show SPP1 Proteins)
Mosaicism for IRAK1 expression is accompanied by skewing toward deficient immune cell populations, producing a phenotype that is preconditioned for improved sepsis outcome
IRAK-1 bypasses priming and directly links Toll (show TLR4 Proteins)-like receptors to rapid NLRP3 (show NLRP3 Proteins) inflammasome activation.
Results describe a new full-length gene model for the bovine IRAK1 gene.
ALOX5AP (show ALOX5AP Proteins), CPNE3 (show CPNE3 Proteins), IL1R2 (show IL1R2 Proteins), IL6 (show IL6 Proteins), TLR2, TLR4 (show TLR4 Proteins), and THY1 (show THY1 Proteins) were upregulated in blood polymorphonuclear cells in negative energy balance versus positive energy balance cows.
This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
interleukin-1 receptor-associated kinase 1
, Pelle homolog
, interleukin-1 receptor-associated kinase-1
, pelle-like protein kinase
, interleukin receptor associated kinase 1