anti-Human IRAK4 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended IRAK4 Antibody (supplied by: Log in to see )

Antigen
Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) Antibodies
  • zgc:55553
  • IRAK4
  • ipd1
  • irak-4
  • ny-ran-64
  • ny-ren-64
  • ren64
  • irak4
  • IPD1
  • IRAK-4
  • NY-REN-64
  • REN64
  • 8430405M07Rik
  • 9330209D03Rik
  • interleukin-1 receptor-associated kinase 4
  • Interleukin-1 receptor-associated kinase 4
  • IRAK4
  • irak4
  • LOC100227974
  • Irak4
Epitope
AA 330-360, pThr345
40
31
15
15
15
14
14
6
6
6
5
5
5
5
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
193
55
27
13
5
4
4
4
2
2
2
2
1
Host
Rabbit
144
33
24
Clonality
Polyclonal
Conjugate
This IRAK4 antibody is un-conjugated
9
8
7
6
5
5
4
3
2
2
2
2
2
2
2
2
2
2
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
153
90
26
26
25
11
11
9
7
5
3
2
2
1
1
1
Options
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Catalog No. ABIN2177052
$ 317.90
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
13.588177 ABIN615818 EIA IHC (p) WB Goat N-Term Log in to see Polyclonal
13.588177 ABIN297197 IHC (p) WB Rabbit IgG AA 38-54 Log in to see Polyclonal
13.588177 ABIN4327519 ICC IF IHC IHC (p) WB Rabbit IgG Center Log in to see Polyclonal
1 ABIN250402 ELISA IHC (p) WB Goat N-Term Log in to see Polyclonal 1
1 ABIN372431 IHC (p) WB Rabbit IgG AA 120-136, AA 38-54 Log in to see Polyclonal
1 ABIN4327517 DB ELISA IHC IHC (p) IP WB Mouse IgG1 kappa pThr345 Log in to see A8A8
1 ABIN740310 IF (p) IHC (p) WB Rabbit IgG AA 20-55 Log in to see Polyclonal
1 ABIN604908 IHC (p) ELISA WB Goat AA 2-13 Log in to see Polyclonal
1 ABIN1498897 IHC (p) WB Rabbit IgG AA 27-288 Log in to see Polyclonal
1 ABIN302830 IF IHC (p) WB Rabbit Log in to see Polyclonal
1 ABIN2177063 IHC (p) HRP Rabbit IgG AA 330-360, pThr345 Log in to see Polyclonal
1 ABIN740319 IHC (p) WB HRP Rabbit IgG AA 20-55 Log in to see Polyclonal
1 ABIN213947 ICC IHC (p) WB Rabbit C-Term Log in to see Polyclonal
1 ABIN1959887 ELISA FACS IHC (p) WB Mouse IgG1 Log in to see 2H9
1 ABIN599243 IHC (p) ELISA WB Mouse IgG AA 1-130 Log in to see 2D3
1 ABIN2177057 IHC (p) Biotin Rabbit IgG AA 330-360, pThr345 Log in to see Polyclonal
1 ABIN740312 IHC (p) WB Biotin Rabbit IgG AA 20-55 Log in to see Polyclonal
1 ABIN1736005 IHC (p) ELISA WB Goat N-Term Log in to see Polyclonal
1 ABIN1736007 IHC (p) WB Rabbit IgG AA 38-54 Log in to see Polyclonal
1 ABIN1736006 ICC IHC (p) WB Rabbit IgG Log in to see Polyclonal

General

Antigen Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) Antibodies
Epitope AA 330-360, pThr345
(40), (31), (15), (15), (15), (14), (14), (6), (6), (6), (5), (5), (5), (5), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(193), (55), (27), (13), (5), (4), (4), (4), (2), (2), (2), (2), (1)
Host Rabbit
(144), (33), (24)
Clonality
Polyclonal
Conjugate This IRAK4 antibody is un-conjugated
(9), (8), (7), (6), (5), (5), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(153), (90), (26), (26), (25), (11), (11), (9), (7), (5), (3), (2), (2), (1), (1), (1)
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Product Details anti-IRAK4 Antibody

Target Details IRAK4 Application Details Handling Images
Purification Purified by Protein A.
Immunogen KLH conjugated Synthesised phosphopeptide derived from human IRAK4 around the phosphorylation site of Thr345
Isotype IgG

Target Details IRAK4

Product Details anti-IRAK4 Antibody Application Details Handling Images back to top
Antigen
Alternative Name IRAK4 (IRAK4 Antibody Abstract)
Background

Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections.

Subcellular location: Cytoplasm

Synonyms: IPD1, REN64, IRAK-4, NY-REN-64, Interleukin-1 receptor-associated kinase 4, Renal carcinoma antigen NY-REN-64, IRAK4

Gene ID 51135
UniProt Q9NWZ3
Research Area Atherosclerosis, Immunology, Receptors, Cytokines, Innate Immunity, Inflammation
Pathways NF-kappaB Signaling, TLR Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades

Application Details

Product Details anti-IRAK4 Antibody Target Details IRAK4 Handling Images back to top
Application Notes IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only

Handling

Product Details anti-IRAK4 Antibody Target Details IRAK4 Application Details Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

Images

Product Details anti-IRAK4 Antibody Target Details IRAK4 Application Details Handling back to top
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) (AA 330-360), (pThr345) antibody (ABIN2177052) Formalin-fixed and paraffin embedded human lung carcinoma labeled with Rabbit Anti-IR...