anti-Mouse (Murine) IRAK4 antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended IRAK4 Antibody (supplied by: Log in to see )

Antigen
Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) Antibodies
  • zgc:55553
  • IRAK4
  • ipd1
  • irak-4
  • ny-ran-64
  • ny-ren-64
  • ren64
  • irak4
  • IPD1
  • IRAK-4
  • NY-REN-64
  • REN64
  • 8430405M07Rik
  • 9330209D03Rik
  • interleukin-1 receptor-associated kinase 4
  • Interleukin-1 receptor-associated kinase 4
  • IRAK4
  • irak4
  • LOC100227974
  • Irak4
Epitope
AA 20-55
40
31
16
15
15
14
14
6
6
6
5
5
5
5
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
193
54
26
13
5
4
4
4
2
2
2
2
1
Host
Rabbit
144
33
24
Clonality
Polyclonal
Conjugate
This IRAK4 antibody is un-conjugated
9
8
7
6
5
5
4
3
2
2
2
2
2
2
2
2
2
2
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
152
90
26
26
25
11
11
9
7
5
3
2
2
1
1
1
Options
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Catalog No. ABIN740310
$ 295.90
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN2814908 IF (p) Alexa Fluor 594 Rabbit IgG AA 20-55 Log in to see Polyclonal
1 ABIN740313 IF (p) Cy3 Rabbit IgG AA 20-55 Log in to see Polyclonal
1 ABIN740314 IF (p) Cy5 Rabbit IgG AA 20-55 Log in to see Polyclonal
1 ABIN740315 IF (p) Cy5.5 Rabbit IgG AA 20-55 Log in to see Polyclonal
1 ABIN740316 IF (p) Cy7 Rabbit IgG AA 20-55 Log in to see Polyclonal
1 ABIN740317 IF (p) FITC Rabbit IgG AA 20-55 Log in to see Polyclonal
1 ABIN903055 IF (p) Alexa Fluor 488 Rabbit IgG AA 20-55 Log in to see Polyclonal
1 ABIN903056 IF (p) Alexa Fluor 555 Rabbit IgG AA 20-55 Log in to see Polyclonal
1 ABIN903054 IF (p) Alexa Fluor 350 Rabbit IgG AA 20-55 Log in to see Polyclonal
1 ABIN903057 IF (p) Alexa Fluor 647 Rabbit IgG AA 20-55 Log in to see Polyclonal
1 ABIN5005548 IF (p) Alexa Fluor 750 Rabbit IgG AA 20-55 Log in to see Polyclonal
1 ABIN5005547 IF (p) Alexa Fluor 680 Rabbit IgG AA 20-55 Log in to see Polyclonal

General

Antigen Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) Antibodies
Epitope AA 20-55
(40), (31), (16), (15), (15), (14), (14), (6), (6), (6), (5), (5), (5), (5), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(193), (54), (26), (13), (5), (4), (4), (4), (2), (2), (2), (2), (1)
Host Rabbit
(144), (33), (24)
Clonality
Polyclonal
Conjugate This IRAK4 antibody is un-conjugated
(9), (8), (7), (6), (5), (5), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(152), (90), (26), (26), (25), (11), (11), (9), (7), (5), (3), (2), (2), (1), (1), (1)
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Product Details anti-IRAK4 Antibody

Target Details IRAK4 Application Details Handling Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human IRAK4
Isotype IgG

Target Details IRAK4

Product Details anti-IRAK4 Antibody Application Details Handling Images back to top
Antigen
Alternative Name Irak4 (IRAK4 Antibody Abstract)
Background

Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections.

Synonyms: IPD1, REN64, IRAK-4, NY-REN-64, Interleukin-1 receptor-associated kinase 4, Renal carcinoma antigen NY-REN-64, IRAK4

Gene ID 51135
UniProt Q9NWZ3
Research Area Immunology, Innate Immunity, Atherosclerosis, Cytokines, Receptors, Inflammation
Pathways NF-kappaB Signaling, TLR Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades

Application Details

Product Details anti-IRAK4 Antibody Target Details IRAK4 Handling Images back to top
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only

Handling

Product Details anti-IRAK4 Antibody Target Details IRAK4 Application Details Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

Images

Product Details anti-IRAK4 Antibody Target Details IRAK4 Application Details Handling back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) (AA 20-55) antibody (ABIN740310) Formalin-fixed and paraffin embedded human endometrium carcinoma labeled with Rabbit ...
ELISA image for anti-Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) (AA 20-55) antibody (ABIN740310) Antigen: 0.2 µg/100 µL Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:...