anti-Mouse (Murine) LTBR antibody for Functional Studies

Recommended LTBR Antibody (supplied by: Log in to see )

Antigen
Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR) Antibodies
  • AI256028
  • CD18
  • LTbetaR
  • Ltar
  • TNF-R-III
  • TNFCR
  • TNFR-RP
  • TNFR2-RP
  • TNFRrp
  • Tnfbr
  • Tnfrsf3
  • D12S370
  • LT-BETA-R
  • TNFR3
  • TNFRSF3
  • lymphotoxin beta receptor (TNFR superfamily, member 3)
  • lymphotoxin B receptor
  • Ltbr
  • LTBR
Epitope
AA 31-221, Cysteine-Rich Domain
24
23
19
16
16
10
10
9
9
6
5
5
5
4
4
3
3
3
2
2
2
2
2
1
1
Reactivity
Mouse (Murine)
168
157
5
1
1
1
1
1
Host
Rat
120
101
77
9
2
Clonality
Monoclonal
Conjugate
This LTBR antibody is un-conjugated
26
20
16
10
10
10
10
10
6
6
6
5
4
4
4
4
4
4
4
4
3
2
2
Application
Functional Studies (Func)
199
124
64
22
15
10
10
10
4
4
3
3
2
2
Options
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Catalog No. ABIN1169122
$ 393.75
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN317398 Func FACS Rat IgG2a Extracellular Domain Log in to see 5G11b 1
1 ABIN1169120 Func FACS Rat IgG2a AA 31-221, Cysteine-Rich Domain Log in to see 4H8 WH2 3
1 ABIN1108069 Func EIA WB Rat IgG2a Log in to see 5G11 3
1 ABIN2475408 Func FACS Rat IgG2a Extracellular Domain Log in to see 5G11b 4
1 ABIN2625012 Func Rat IgG1, kappa AA 31-221 Log in to see 3C8
1 ABIN1819767 Func FACS Rat IgG2a Extracellular Domain Log in to see 5G11b
1 ABIN596376 Func FACS Rat IgG2a Extracellular Domain Log in to see
1 ABIN2586456 Func Rat IgG1, kappa AA 31-221 Log in to see 3C8
1 ABIN2586455 Func FACS Rat IgG2a AA 31-221 Log in to see 4H8 WH2
1 ABIN1169121 Func Rat IgG1 AA 31-221, Cysteine-Rich Domain Log in to see 3C8
1 ABIN2586454 Func FACS Rat IgG2a AA 31-221 Log in to see 4H8 WH2
1 ABIN601771 Func FACS WB Rat IgG2a Log in to see
1 ABIN5564240 FACS Func Rat IgG2a AA 31-221, Cysteine-Rich Domain Log in to see 4H8 WH2
1 ABIN642451 Func FACS Rat Log in to see

General

Antigen Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR) Antibodies
Epitope AA 31-221, Cysteine-Rich Domain
(24), (23), (19), (16), (16), (10), (10), (9), (9), (6), (5), (5), (5), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1)
Reactivity Mouse (Murine)
(168), (157), (5), (1), (1), (1), (1), (1)
Host Rat
(120), (101), (77), (9), (2)
Clonality (Clone)
Monoclonal   ( )
Conjugate This LTBR antibody is un-conjugated
(26), (20), (16), (10), (10), (10), (10), (10), (6), (6), (6), (5), (4), (4), (4), (4), (4), (4), (4), (4), (3), (2), (2)
Application Functional Studies (Func)
(199), (124), (64), (22), (15), (10), (10), (10), (4), (4), (3), (3), (2), (2)
Pubmed 3 references available
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Product Details anti-LTBR Antibody

Target Details LTBR Application Details Handling References for anti-LTBR antibody (ABIN1169122) Images
Specificity Recognizes mouse LTbetaR.
Cross-Reactivity Mouse (Murine)
Purification Purified from concentrated hybridoma tissue culture supernatant.
Purity >95 % (SDS-PAGE)
Immunogen Recombinant mouse LTbetaR (cysteine-rich region) (aa 31-221).
Clone 3C8
Isotype IgG1
Fragment kappa

Target Details LTBR

Product Details anti-LTBR Antibody Application Details Handling References for anti-LTBR antibody (ABIN1169122) Images back to top
Antigen
Alternative Name LTbetaR (LTBR Antibody Abstract)
Background The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.
UniProt P50284
Pathways NF-kappaB Signaling

Application Details

Product Details anti-LTBR Antibody Target Details LTBR Handling References for anti-LTBR antibody (ABIN1169122) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Comment

The monoclonal antibody to mouse LTbetaR is an agonist that can be used for the investigation of the regulation of BAFF (BlyS), chemokines and integrins using in vivo and tissue culture models, the development of NK cells and NK T cells, to study the regulation of NF-kappaB family of transcription factors in regulation of inflammation and homeostasis, particularly RelB NF-kappaB2 pathway. For use as an agonist the MAb to LTbetaR is added to cell cultures at 2μg/ml. For in vivo use, mice are injected intraperitoneally with 50μg of agonistic MAb to LTbetaR in sterile phosphate saline buffer.

Restrictions For Research Use only

Handling

Product Details anti-LTBR Antibody Target Details LTBR Application Details References for anti-LTBR antibody (ABIN1169122) Images back to top
Format Liquid
Concentration 1 mg/mL
Buffer In PBS containing 10 % glycerol and 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.
Expiry Date 12 months

References for anti-LTBR antibody (ABIN1169122)

Product Details anti-LTBR Antibody Target Details LTBR Application Details Handling Images back to top
Product cited in:

Vondenhoff, Greuter, Goverse, Elewaut, Dewint, Ware, Hoorweg, Kraal, Mebius: "LTbetaR signaling induces cytokine expression and up-regulates lymphangiogenic factors in lymph node anlagen." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 9, pp. 5439-45, 2009

Benedict, De Trez, Schneider, Ha, Patterson, Ware: "Specific remodeling of splenic architecture by cytomegalovirus." in: PLoS pathogens, Vol. 2, Issue 3, pp. e16, 2006

Banks, Rickert, Benedict, Ma, Ko, Meier, Ha, Schneider, Granger, Turovskaya, Elewaut, Otero, French, Henry, Hamilton, Scheu, Pfeffer, Ware: "A lymphotoxin-IFN-beta axis essential for lymphocyte survival revealed during cytomegalovirus infection." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 11, pp. 7217-25, 2005