anti-Human MAP3K7 antibody for Enzyme Immunoassay

Recommended MAP3K7 Antibody (supplied by: Log in to see )

Antigen
Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7) Antibodies
  • si:ch211-225h9.1
  • zgc:110612
  • Tak1
  • MEKK7
  • TAK1
  • TGF1a
  • B430101B05
  • C87327
  • mitogen activated protein kinase kinase kinase 7
  • mitogen-activated protein kinase kinase kinase 7
  • map3k7
  • Map3k7
  • MAP3K7
Epitope
pSer192
30
18
18
16
14
13
10
9
6
5
4
4
4
3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
175
71
59
6
6
5
5
5
5
4
3
2
2
2
2
1
1
Host
Rabbit
151
13
13
Clonality
Polyclonal
Conjugate
This MAP3K7 antibody is un-conjugated
9
9
9
9
9
9
Application
Dot Blot (DB), Enzyme Immunoassay (EIA)
145
103
49
34
19
6
6
4
2
1
1
1
1
Supplier
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Catalog No. ABIN358312
$ 390.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN360354 EIA IHC (p) WB Rabbit Ig C-Term Log in to see Polyclonal 5
1 ABIN358291 EIA Rabbit Ig Thr187, pThr187 Log in to see Polyclonal 5
1 ABIN5611536 EIA IHC (p) WB Rabbit IgG Internal Region Log in to see Polyclonal
1 ABIN5555292 EIA WB Rabbit IgG N-Term Log in to see Polyclonal

General

Antigen Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7) Antibodies
Epitope pSer192
(30), (18), (18), (16), (14), (13), (10), (9), (6), (5), (4), (4), (4), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(175), (71), (59), (6), (6), (5), (5), (5), (5), (4), (3), (2), (2), (2), (2), (1), (1)
Host Rabbit
(151), (13), (13)
Clonality
Polyclonal
Conjugate This MAP3K7 antibody is un-conjugated
(9), (9), (9), (9), (9), (9)
Application Dot Blot (DB), Enzyme Immunoassay (EIA)
(145), (103), (49), (34), (19), (6), (6), (4), (2), (1), (1), (1), (1)
Pubmed 5 references available
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Product Details anti-MAP3K7 Antibody

Target Details MAP3K7 Application Details Handling References for anti-MAP3K7 antibody (ABIN358312) Images
Specificity This antibody detects TAK1 / MAP3K7 pSer192.
Cross-Reactivity (Details) Species reactivity (expected):Mouse (100 % Antigen Homology).
Species reactivity (tested):Human.
Purification Protein A Chromatography followed by two-step phosphospecific peptide affinity purification
Immunogen KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Ser192 of Human MAP3K7. Genename: MAP3K7
Isotype Ig

Target Details MAP3K7

Product Details anti-MAP3K7 Antibody Application Details Handling References for anti-MAP3K7 antibody (ABIN358312) Images back to top
Antigen
Alternative Name TAK1 / MAP3K7 (MAP3K7 Antibody Abstract)
Background MAP3K7 is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2, this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses.Synonyms: Mitogen-activated protein kinase kinase kinase 7, TAK-1, TAK1, TGF-beta-activated kinase 1, Transforming growth factor-beta-activated kinase 1
Molecular Weight 67196 Da
Gene ID 6885, 9606
UniProt O43318
Pathways NF-kappaB Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Toll-Like Receptors Cascades

Application Details

Product Details anti-MAP3K7 Antibody Target Details MAP3K7 Handling References for anti-MAP3K7 antibody (ABIN358312) Images back to top
Application Notes ELISA: 1/1,000. Dot Blot: 1/100-1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-MAP3K7 Antibody Target Details MAP3K7 Application Details References for anti-MAP3K7 antibody (ABIN358312) Images back to top
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS, 0.09 % (W/V) Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

References for anti-MAP3K7 antibody (ABIN358312)

Product Details anti-MAP3K7 Antibody Target Details MAP3K7 Application Details Handling Images back to top
Background publications

Smit, Baas, Kuipers, Korswagen, van de Wetering, Clevers: "Wnt activates the Tak1/Nemo-like kinase pathway." in: The Journal of biological chemistry, Vol. 279, Issue 17, pp. 17232-40, 2004

Ono, Ohtomo, Ninomiya-Tsuji, Tsuchiya: "A dominant negative TAK1 inhibits cellular fibrotic responses induced by TGF-beta." in: Biochemical and biophysical research communications, Vol. 307, Issue 2, pp. 332-7, 2003

Sakurai, Suzuki, Kawasaki, Nakano, Okazaki, Chino, Doi, Saiki: "Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway." in: The Journal of biological chemistry, Vol. 278, Issue 38, pp. 36916-23, 2003

Cheung, Campbell, Nebreda, Cohen: "Feedback control of the protein kinase TAK1 by SAPK2a/p38alpha." in: The EMBO journal, Vol. 22, Issue 21, pp. 5793-805, 2003

Edlund, Bu, Schuster, Aspenström, Heuchel, Heldin, ten Dijke, Heldin, Landström et al.: "Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase ..." in: Molecular biology of the cell, Vol. 14, Issue 2, pp. 529-44, 2003

Images

Product Details anti-MAP3K7 Antibody Target Details MAP3K7 Application Details Handling References for anti-MAP3K7 antibody (ABIN358312) back to top
Supplier Images
 image for anti-Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7) (pSer192) antibody (ABIN358312) anti-Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7) (pSer192) antibody