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|Application / Reactivity||Human||Mouse (Murine)||Rat (Rattus)||Monkey|
|Simple Western (SimWes)||1 Antibodies||1 Antibodies||1 Antibodies|
|Western Blotting (WB)||216 Antibodies||89 Antibodies||42 Antibodies||5 Antibodies|
|SDS-PAGE (SDS)||1 Antibodies||1 Antibodies||1 Antibodies|
|Immunoprecipitation (IP)||4 Antibodies||1 Antibodies||1 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||36 Antibodies||16 Antibodies||11 Antibodies|
|Immunohistochemistry (IHC)||60 Antibodies||29 Antibodies|
|Antigen||Myeloid Differentiation Primary Response Gene (88) (MYD88) Antibodies|
|Reactivity||Human, Monkey, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This MYD88 antibody is un-conjugated Alternatives|
Western Blotting (WB)
|1 reference available|
|Supplier||Log in to see|
Product Details anti-MYD88 AntibodyTarget Details MYD88 Application Details Handling References for anti-MYD88 Antibody (ABIN809502) Images
|Blocking Peptide||Blocking peptide for this product available: ABIN809691|
|Immunogen||Synthetic peptide surrounding amino acid 283 of rat MyD88|
Target Details MYD88Product Details anti-MYD88 Antibody Application Details Handling References for anti-MYD88 Antibody (ABIN809502) Images back to top
|Alternative Name||MYD88 (MYD88 Antibody Abstract)|
MyD88 was identified as an adapter molecule in the IL-1 signaling pathway. MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment. Dominant-negative form of MyD88 attenuates IL-1R-mediated NF-B activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor, which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in loss of cellular responses to IL-1 and IL-18. MyD88 is a general adaptor protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many tissues.
Synonyms: Myeloid differentiation primary response protein, MyD88
|Pathways||NF-kappaB Signaling, TLR Signaling, Neurotrophin Signaling Pathway|
Application DetailsProduct Details anti-MYD88 Antibody Target Details MYD88 Handling References for anti-MYD88 Antibody (ABIN809502) Images back to top
Western Blot analysis (0.5-4 μg/mL).
However, the optimal concentrations should be determined individually.
Suggested positive control: Rat kidney tissue lysate
|Restrictions||For Research Use only|
HandlingProduct Details anti-MYD88 Antibody Target Details MYD88 Application Details References for anti-MYD88 Antibody (ABIN809502) Images back to top
|Buffer||100 μg (0.5 mg/mL) affinity purified rabbit anti- MyD88 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30 % glycerol, 0.5 % BSA, 5 mM EDTA and 0.01 % thimerosal|
|Precaution of Use||This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
|Storage Comment||For long-term storage, aliquot and freeze at -70 °C.|
|Expiry Date||12 months|
References for anti-MYD88 Antibody (ABIN809502)Product Details anti-MYD88 Antibody Target Details MYD88 Application Details Handling Images back to top
|Product cited in:||
Abe, Hirasaka, Kagawa, Kohno, Ochi, Utsunomiya, Sakai, Ohno, Teshima-Kondo, Okumura, Oarada, Maekawa, Terao, Mills, Nikawa: "Cbl-b is a critical regulator of macrophage activation associated with obesity-induced insulin resistance in mice." in: Diabetes, Vol. 62, Issue 6, pp. 1957-69, 2013
ImagesProduct Details anti-MYD88 Antibody Target Details MYD88 Application Details Handling References for anti-MYD88 Antibody (ABIN809502) back to top