|Antigen||Myeloid Differentiation Primary Response Gene (88) (MYD88) Antibodies|
|Reactivity||Sponges (Suberites domuncula) Alternatives|
|Conjugate||This MYD88 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
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Product Details anti-MYD88 AntibodyTarget Details MYD88 Application Details Handling Images
|Specificity||This antibody detects MyD88.|
|Immunogen||Recombinant MyD88 from Suberites domuncula|
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|Alternative Name||MYD88 (MYD88 Antibody Abstract)|
|Background||Myeloid differentiation Marker 88 (MyD88) is an adaptor molecule for the Toll/IL1R and is involved in the inflammatory response induced by IL1, IL18 and LPS. MyD88 associates with and recruits IRAK to IL1 receptor complex in response to IL1. This pathway further leads to activation of NFkB. Targeted disruption of the MyD88 gene results in loss of cellular responses to IL1 and IL18, and MyD88 deficient mice lack responses to bacterial product LPS that employs Toll like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 has a wide tissue distribution.Synonyms: Myeloid differentiation primary response protein MyD88|
|Pathways||NF-kappaB Signaling, TLR Signaling, Neurotrophin Signaling Pathway|
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ELISA (1: 10.000). Western blot (1: 2.000). Immunohistochemistry (1: 500).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
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|Reconstitution||Restore in aqua bidest to initial volume.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store lyophilized at 2 - 8 °C and reconstituted at -20 °C.|
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